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Latest Survival motor neuron spinal muscular atrophy Stories

2012-03-07 11:16:28

Spinal muscular atrophy (SMA) is an incurable, and progressive, disease caused by an inheritable defect in the gene SMN1. Depending on the severity of the mutation it can result in the loss of spinal cord motor neurons, muscle wasting (atrophy) and even death of an affected child. A new study published in Biomed Central's open access journal BMC Medicine shows that Fasudil, a ROCK inhibitor, can improve both the size of muscle fibers and their connection to motor neurons. Fasudil also...

2011-11-22 10:30:37

Spinal Muscular Atrophy affects one in 6,000 children; no known cure A team of University of Missouri researchers have found that targeting a synthetic molecule to a specific gene could help the severity of the disease Spinal Muscular Atrophy (SMA) — the leading genetic cause of infantile death in the world. "When we introduced synthetic RNA into mice that carry the genes responsible for SMA, the disease's severity was significantly lowered," said Chris Lorson, researcher at the...

2011-10-20 12:10:00

These new awards encompass $745,000 for the basic research portion of the $3 Million in new research funding that FSMA announced earlier this year. The FSMA basic research program is governed by the Scientific Advisory Board (SAB). The SAB carefully reviews all grant applications to ensure funding of only the best quality research relevant to the mission of Families of SMA. Chicago, IL (PRWEB) October 20, 2011 Three of the seven new grants for 2011 will help the understanding of why motor...

2011-10-05 19:32:27

Findings reveal that deficiency of the SMN protein in peripheral tissues might also contribute to SMA pathology A new study from Cold Spring Harbor Laboratory (CSHL) reports surprising results that suggest that the devastating neuromuscular disease, spinal muscular atrophy (SMA), might not exclusively affect the motor neurons in the spinal cord as has long been thought. The new findings suggest that defects in peripheral tissues such as liver, muscle, heart, etc., might also contribute to...

2011-07-25 23:28:09

'Biggest increase anyone has seen' in the production of essential compound for deadly childhood disease Researchers in Ottawa report new hope for the treatment of infants born with serious genetic disorder. Over 1000 children in Canada are affected with Spinal Muscular Atrophy (SMA), a genetic disorder that causes muscle weakness and loss of motor control. In its most severe form survival of children with SMA beyond 5 years is rare. Although the disorder is caused by the loss of a specific...

2011-07-25 23:27:04

Spinal muscular atrophy (SMA) is the most frequently inherited cause of infant mortality. Two independent research groups "” one led by Alex MacKenzie, at Children's Hospital of Eastern Ontario Research Institute, Ottawa; and one led by Umrao R. Monani, at Columbia University Medical Center, New York, and Cathleen M. Lutz, at The Jackson Laboratory, Bar Harbor "” have now generated new data in mouse models of severe SMA that provide hope that a therapeutic providing meaningful...

2011-06-06 14:00:00

Failure in nerve-fiber navigation corrected in zebrafish model; suggests possibility of a drug treatment BOSTON, June 6, 2011 /PRNewswire-USNewswire/ -- Spinal muscular atrophy (SMA) is the leading genetic cause of death in children under 2, with no treatment other than supportive care. In the Proceedings of the National Academy of Sciences (Early Edition, week of June 6), researchers at Children's Hospital Boston show how loss or mutation of the SMA gene causes progressive muscle...

2010-08-11 14:10:00

Study details new findings in mouse model of disease; highlights existing gene delivery approach that may provide therapy Along with skeletal muscles, it may be important to monitor heart function in patients with spinal muscular atrophy (SMA). These are the findings from a study conducted by Nationwide Children's Hospital and published online ahead of print in Human Molecular Genetics. This is the first study to report cardiac dysfunction in mouse models of SMA. SMA is a debilitating...

2010-06-10 13:09:40

Children who suffer from the devastating disease Spinal Muscular Atrophy are set to benefit from a new breakthrough in therapy developments by researchers at the University of Sheffield. The research, which was published yesterday (9 June 2010) in Science Translational Medicine, has shown that a novel gene transfer system has the potential to provide an effective therapeutic treatment for SMA patients. SMA is a devastating motor neuron disease which affects children. It is caused by an...

2010-03-15 13:48:51

Scientists from the Ottawa Hospital Research Institute (OHRI) and the University of Ottawa have identified a promising new approach for developing drugs to treat Spinal muscular atrophy (SMA), the leading inherited cause of death in infants and toddlers. Dr. Rashmi Kothary and his doctoral student Melissa Bowerman have found that an enzyme called RhoA is overly active in a mouse model of the disease and blocking this enzyme can greatly increase survival. The study is published in Human...


Word of the Day
barratry
  • The offense of persistently instigating lawsuits, typically groundless ones.
  • An unlawful breach of duty on the part of a ship's master or crew resulting in injury to the ship's owner.
  • Sale or purchase of positions in church or state.
This word ultimately comes from the Old French word 'barater,' to cheat.
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