Quantcast
Last updated on April 16, 2014 at 21:24 EDT

Latest SV40 Stories

Single Mutation Gives Virus A New Target
2013-10-22 13:34:16

Brown University In a new study published online in the journal PLoS Pathogens, an international team of scientists showed that by swapping a single amino acid they could change the sugar to which the human BK polyomavirus will bind on the surface of cells. The BK polyomavirus lost the ability to bind its usual target sugar and instead “preferred” the same sugar as its cousin SV40 polyomavirus, which is active in monkeys. The researchers were working in cell cultures with safe...

2008-09-07 03:00:07

By Valle, Luis Del White, Martyn K; Khalili, Kamel Abstract The human polyomavirus JC (JCV) is a small DNA tumor virus and the etiologic agent of the progressive multifocal leukoencephalopathy. In progressive multifocal leukoencephalopathy, active JCV replication causes the lytic destruction of oligodendrocytes. The normal immune system prevents JCV replication and suppresses the virus into a state of latency so that expression of viral proteins cannot be detected. In a cellular context...

2008-04-25 03:00:20

By Shishido-Hara, Yukiko Higuchi, Kayoko; Ohara, Sinji; Duyckaerts, Charles; Hauw, Jean-Jacques; Uchihara, Toshiki Abstract Progressive multifocal leukoencephalopathy is a fatal demyelinating disorder due to human polyomavirus JC infection in which there are viral inclusions in enlarged nuclei of infected oligodendrocytes. We report that the pathogenesis of this disease is associated with distinct subnuclear structures known as promyelocytic leukemia nuclear bodies (PML-NBs). Postmortem...

2005-06-02 15:05:16

In the latest version of the hide-and-seek game between pathogens and the hosts they infect, researchers have found that a virus appears to cloak itself with a recently discovered gene silencing device to evade detection and destruction by immune cells. The report by Howard Hughes Medical Institute (HHMI) researchers in an article published in the June 2, 2005, issue of Nature may be the first to show how a virus uses the gene silencing machinery for its own infectious purposes. In people,...


Latest SV40 Reference Libraries

45_c8d4395f53eb6d3d4b08458e135e5ef0
2011-02-23 17:31:48

Polyomavirus is the sole genus of viruses within the family Polyomaviridae. Ludwik Gross discovered the first polyomavirus, Murine polyomavirus, in 1963. Many polyomaviruses infect birds and mammals and have been extensively studied as tumor viruses in humans and animals. Polyomaviruses are DNA-based, small, and icosahedral in shape. They can potentially cause tumors and often persist as latent infections in a host without causing disease. There are three major clades or...

More Articles (1 articles) »