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After more than a century of study, mysteries still remain about the process of meiosis—a special type of cell division that helps insure genetic diversity in sexually-reproducing organisms.
In children with genomic disorders, often a gamete – egg or sperm – has gone disastrously awry with either a duplication or deletion of genetic material that results in physical and neurological problems for the subsequent child.
SAO PAULO, Dec.
Meiosis â€“ the pairing and recombination of chromosomes, followed by segregation of half to each egg or sperm cell â€“ is a major crossroads in all organisms reproducing sexually.
Using yeast genetics and a novel scheme to selectively remove a single protein from the cell division process called meiosis, a cell biologist at The Florida State University found that when a key molecular player known as Pds5 goes missing, chromosomes fail to segregate and pair up properly, and birth defects such as Down syndrome can result.
- An armed gangster.