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Latest Systematic review Stories

2013-12-02 21:34:45

Procedure for report production and section on meta-analyses updated / New sections on early benefit assessment The German Institute for Quality and Efficiency in Health Care (IQWiG) has completed the first step in the revision of its methods paper and published the version “General Methods 4.1” on the Internet on 28 November 2013. From now on the new document forms the basis for the scientific work of the Institute and its external experts and for collaboration with the commissioning...

2013-07-17 10:19:17

A new study published in the open access journal PLOS Biology suggests that the scientific literature could be compromised by substantial bias in the reporting of animal studies, and may be giving a misleading picture of the chances that potential treatments could work in humans. Testing a new therapeutic intervention (such as a drug or surgical procedure) on human subjects is expensive, risky and ethically complex, so the vast majority are first tested on animals. Unfortunately, cost and...

2013-07-17 10:17:59

Clinical trials of drug treatments for neurological diseases such as Alzheimer's and Parkinson's often fail because the animal studies that preceded them were poorly designed or biased in their interpretation, according to a new study from an international team of researchers. More stringent requirements are needed to assess the significance of animal studies before testing the treatments in human patients, the researchers say. The team - led by John Ioannidis, MD, DSc, a professor of...

2013-07-17 10:06:02

Many new developments and initiatives have been introduced to improve the quality and translational value of animal research, and must continue with support from the wider scientific community. These are the conclusions of a new article in PLOS Medicine this week by Carlijn Hooijmans and colleagues from the Radboud University Nijmegen Medical Centre, Netherlands, who summarize these new developments. Focusing on the quality of study conduct, reporting, and replication; systematic reviews...

2013-04-10 13:59:34

New guidelines for writing abstracts will help authors summarize their research A new extension to the PRISMA guideline on reporting systemic reviews and meta-analyses (types of studies that analyze information from many studies) will help authors to give a more robust summary (abstract) of their study and is detailed by an international group of researchers in this week's PLOS Medicine. These guidelines for abstracts of systemic reviews and meta-analyses are important, as the abstract...

2011-09-07 12:24:52

There is growing use of financial incentives in many countries to reward primary care practitioners who improve the quality of their services. After reviewing all available data in a Cochrane Systematic Review, a team of researchers found insufficient evidence to either support or refute the practice. They conclude that policymakers need to proceed with caution before setting up an incentive scheme and think carefully about the way it is designed. There are hundreds of schemes in the USA,...

2011-08-25 21:07:36

S. Stanley Young, assistant director for bioinformatics at the National Institute of Statistical Sciences (NISS), and Alan Karr, director at NISS, have published a non-technical article in the September issue of Significance magazine pointing out that medical and other observational studies often produce results that are later shown to be incorrect, and–invoking a quality control perspective–suggest ways to fix the system. Their central point is that the current system of...

2011-05-04 12:39:22

Systematic reviews that attempt to assess the risk of harms (adverse effects) associated with specific therapies should consider a broad range of study designs, including both systematic reviews and observational studies. These are the findings of a new study, led by Su Golder of the Centre for Reviews and Dissemination, University of York, UK published in this week's PLoS Medicine. There is increasing focus on the importance of using rigorous methods to assess the effectiveness and harms...


Word of the Day
humgruffin
  • A terrible or repulsive person.
Regarding the etymology of 'humgruffin,' the OED says (rather unhelpfully) that it's a 'made-up word.' We might guess that 'hum' comes from 'humbug' or possibly 'hum' meaning 'a disagreeable smell,' while 'gruffin' could be a combination of 'gruff' and 'griffin.'