Latest Systematic review Stories
The German Institute for Quality and Efficiency in Health Care (IQWiG) has completed the first step in the revision of its methods paper and published the version “General Methods 4.1” on the Internet on 28 November 2013.
A new study published in the open access journal PLOS Biology suggests that the scientific literature could be compromised by substantial bias in the reporting of animal studies, and may be giving a misleading picture of the chances that potential treatments could work in humans.
Clinical trials of drug treatments for neurological diseases such as Alzheimer's and Parkinson's often fail because the animal studies that preceded them were poorly designed or biased in their interpretation.
Many new developments and initiatives have been introduced to improve the quality and translational value of animal research, and must continue with support from the wider scientific community.
A new extension to the PRISMA guideline on reporting systemic reviews and meta-analyses (types of studies that analyze information from many studies) will help authors to give a more robust summary (abstract) of their study and is detailed by an international group of researchers in this week's PLOS Medicine.
There is growing use of financial incentives in many countries to reward primary care practitioners who improve the quality of their services.
S. Stanley Young, assistant director for bioinformatics at the National Institute of Statistical Sciences (NISS), and Alan Karr, director at NISS, have published a non-technical article in the September issue of Significance magazine pointing out that medical and other observational studies often produce results that are later shown to be incorrect, and—invoking a quality control perspective—suggest ways to fix the system.
Systematic reviews that attempt to assess the risk of harms (adverse effects) associated with specific therapies should consider a broad range of study designs, including both systematic reviews and observational studies.
- Monstrous in size or character; huge; prodigious; monstrously perverse, savage, cruel, etc.