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Latest T-cadherin Stories

2014-05-23 11:10:34

UCSB UCSB study shows that key protein in epithelial cells plays important roles in how cells sense direction What do sled dogs and cell clusters have in common? According to research by UC Santa Barbara’s Denise Montell, they both travel in groups and need a leader to make sure they all follow in the same direction. Montell, Duggan Professor of Molecular Cellular and Developmental Biology, and colleagues worked on three independent projects involving E-cadherin, a protein found in...

2014-04-02 15:55:01

New research at Washington University School of Medicine in St. Louis and Vanderbilt University Medical Center in Nashville has implicated a poorly understood protein called PLAC8 in the spread of colon cancer. While elevated PLAC8 levels were known to be associated with colon cancer, the researchers now have shown that the protein plays an active role in shifting normal cells lining the colon into a state that encourages metastasis. The work appears April 1 in the Journal of Clinical...

2014-01-24 13:30:41

A team of scientists, led by principal investigator David D. Schlaepfer, PhD, a professor in the Department of Reproductive Medicine at the University of California, San Diego School of Medicine, has found that a protein involved in promoting tumor growth and survival is also activated in surrounding blood vessels, enabling cancer cells to spread into the bloodstream. The findings are published in this week's online issue of the Journal of Cell Biology. Blood vessels are tightly lined...

2012-03-15 16:56:52

American Cancer Society-Funded Research Reveals Molecule Called Cadherin-23 Could Play a Role in the Earliest Stages of Breast Cancer Rensselaer Polytechnic Institute Biologist Lee Ligon has found a previously unknown connection between breast cancer tumor cells and the surrounding healthy tissue. The results provide new information on the earliest stages of breast cancer metastasis. The results were published March 7, 2012, in the journal PLoS One, in a paper titled “ Cadherin-23...

2012-03-14 21:14:04

A new study by University of Kentucky researchers provides insight into developing new treatment strategies for basal-like breast cancer, commonly known as triple-negative breast cancer. This cancer is associated with early metastasis and resistance to chemotherapy and occurs at women at a younger age. Tumor cells can exploit a cellular program that promotes cell migration and reduces adhesion between cells to spread to distant sites in the body. This cellular program, known as the...

2012-03-06 11:05:26

Discovered a mechanism explaining how tumor cells spread to nearby organs and structures, initiating metastasis Metastasis is responsible for 90% of deaths in patients with cancer. Understanding the mechanisms responsible for this process is one of the top goals of cancer research. The metastatic process involves a series of steps chained where the primary tumour invades surrounding tissues and ends spreading throughout the body. Ones of the first tissues undergoing metastasis are the...

2012-01-20 10:59:48

Novel imaging platform reveals new details on disease development When cancers become aggressive and spread they are the most deadly. Unfortunately, little is known about how to stop this development. A new imaging platform developed by Lawson Health Research Institute's Drs. Ann Chambers and John Lewis is providing insight into just that - the exact moment when cancer cells turn deadly. Certain proteins, such as E-cadherin, are important for the maintenance of normal tissue structure....

2011-12-21 19:32:59

Cell-surface protein N-cadherin represents a promising therapeutic target for the treatment of pancreatic cancer, say researchers at Jefferson's Center for Translational Medicine Often, and without much warning, pancreatic cancer cells slip through the endothelial cells, head into the blood and out to other parts of the body to metastasize, making it one of the deadliest and hardest to treat cancers today. Now, researchers from Thomas Jefferson University's Center for Translational...

2011-07-15 14:33:24

A protein molecule that 'glues' cells together and so has a key role in cancer is also responsible for many other important functions of cells, a new study has found. University of Manchester scientists say their unexpected findings are important because they could lead to a better understanding of why some cancer cells are difficult to eradicate in patients and lead to new cancer treatments. The research "“ published in PLoS One today "“ looked at the role of the cell-adhesion...

2010-12-13 20:55:09

A remarkable discovery into how tumor cells invade normal tissue should lead to vital diagnostic tools and help develop strategies to stop the spread of cancer cells. A new study by scientists at the Montreal Neurological Institute and Hospital of McGill University reveals that the surface of aggressive tumor cells lack the strong molecular "Ëœglue' responsible for binding normal cells together. This allows tumor cells to break away, detach from their neighbors, and spread to other...


Word of the Day
call-note
  • The call or cry of a bird or other animal to its mate or its young.
'Call-note' is newer than 'bird-call,' which originally referred to 'an instrument for imitating the note of birds' but now also refers to 'the song or cry of a bird.'
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