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Latest T cell Stories

2014-06-05 13:21:24

VIB (the Flanders Institute for Biotechnology) Researchers at VIB and Ghent University have unraveled the mechanism of necroptosis. This is a type of cell death that plays a crucial role in numerous diseases, from viral infections and loss of auditory nerve cells to multiple sclerosis, acute heart failure and organ transplantation. Having detailed knowledge of the cell death process enables a targeted search for new drugs. Peter Vandenabeele (VIB/UGent): "The molecular mechanism of...

Surprising Similarities In The Way Immune System Defenders Bind To Disease-causing Invaders
2014-05-27 03:50:47

By Glenn Roberts Jr., Stanford University A study led by researchers at Stanford's School of Medicine reveals how T cells, the immune system's foot soldiers, respond to an enormous number of potential health threats. X-ray studies at the Department of Energy's SLAC National Accelerator Laboratory, combined with Stanford biological studies and computational analysis, revealed remarkable similarities in the structure of binding sites, which allow a given T cell to recognize many...

2014-05-26 13:21:07

University of Texas M. D. Anderson Cancer Center Peptide antibodies hit immune-response-stifling MDSCs without harming other vital cells Scientists have found a way to target elusive cells that suppress immune response, depleting them with peptides that spare other important cells and shrink tumors in preclinical experiments, according to a paper published online by Nature Medicine. "We've known about these cells blocking immune response for a decade, but haven't been able to shut...

2014-05-07 12:28:14

CINCINNATI, May 7, 2014 /PRNewswire-USNewswire/ -- A new study in Nature challenges research data that form the scientific basis of clinical trials in which heart attack patients are injected with stem cells to try and regenerate damaged heart tissue. http://photos.prnewswire.com/prnvar/20110406/MM79025LOGO Researchers at Cincinnati Children's Hospital Medical Center and the Howard Hughes Medical Institute (HHMI), report May 7 that cardiac stem cells used in ongoing clinical trials...

2014-04-14 10:56:31

Manipulating the metabolic process in cells may compensate for defects that can shorten cell life UAlberta researchers are taking a closer look at how two metabolic pathways interact to increase the lifespan of cells with mitochondrial defects. Magnus Friis (PhD ’10) is the lead author of the study, which was published online on April 10 and will be published in the April 24 issue of Cell Reports. Mitochondria produce energy for cells through oxidative metabolism, but the process...

2014-04-11 12:54:50

Too much of a protein called c-FLIPR can trigger autoimmune diseases Apoptosis is used by cells that are changed by disease or are simply not needed any longer to eliminate themselves before they become a hazard to the body—on a cellular level, death is part of life. Disruption of this process can lead to cancer or immunodeficiencies, but also to autoimmune diseases, in which cells attack their own body. HZI scientist Prof Ingo Schmitz and his team investigate the regulation of...

2014-04-01 13:02:44

Antibiotics being explored for the treatment of cystic fibrosis and muscular dystrophy have the potential to trigger autoimmune disease The code for every gene includes a message at the end of it that signals the translation machinery to stop. Some diseases, such as cystic fibrosis and Duchenne muscular dystrophy, can result from mutations that insert this stop signal into the middle of an essential gene, causing the resulting protein to be truncated. Some antibiotics cause the cell's...

2014-03-28 09:26:17

A combination of genetic predisposition and environmental factors is believed to cause autoimmune (type 1) diabetes. A study published on March 27th in PLOS Pathogens gets at the mechanisms by which rotavirus infection contributes to autoimmune diabetes in a mouse model of the disease. NOD (for non-obese diabetic) mice are prone to develop diabetes, and infection with rotavirus accelerates onset of the disease. Barbara Coulson and colleagues, from The University of Melbourne, Australia,...

2014-02-14 16:25:28

Featured Talk Emphasizes Importance of Antigen-Specific Dendritic Cell Cancer Vaccines to Generate Powerful T-Cell Response LOS ANGELES, Feb. 14, 2014 /PRNewswire/ -- ImmunoCellular Therapeutics, Ltd. ("ImmunoCellular") (NYSE MKT: IMUC) today announced that the Company's Founder and Chief Scientific Officer, John S. Yu, MD, delivered a presentation highlighting the therapeutic importance of utilizing antigen-specific dendritic cell (DC) cancer vaccines for inducing a potent T-cell...

Researchers Discover How To Change Cell Types By Flipping A Single Switch
2013-12-04 13:05:09

University of California - Santa Barbara With few exceptions, cells don't change type once they have become specialized — a heart cell, for example, won't suddenly become a brain cell. However, new findings by researchers at UC Santa Barbara have identified a method for changing one cell type into another in a process called forced transdifferentiation. Their work appears today in the journal Development. With C. elegans as the animal model, lead author Misty Riddle, a Ph.D. student...


Latest T cell Reference Libraries

Thymus
2013-03-04 12:56:08

The thymus gland is an endocrine organ of the immune system located anteriolateral to the trachea and in between the lungs. Its primary function is to build T lymphocytes for the body’s immune system; therefore, it is most important during childhood and puberty, when it reaches its maximum size. After puberty, it will begin to atrophy and shrink in size. Old age generally brings about hypotrophy of the thymus. In children the thymus is grayish-pink in color and in adults it is yellow. On...

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Word of the Day
humgruffin
  • A terrible or repulsive person.
Regarding the etymology of 'humgruffin,' the OED says (rather unhelpfully) that it's a 'made-up word.' We might guess that 'hum' comes from 'humbug' or possibly 'hum' meaning 'a disagreeable smell,' while 'gruffin' could be a combination of 'gruff' and 'griffin.'