Latest T cell Stories

Researchers at the Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC-James) have identified an experimental agent that targets chronic lymphocytic leukemia and perhaps other proliferative disorders of lymphocytes.Their study shows that the small-molecule inhibitor CAL-101 directly promotes cell death by apoptosis in chronic lymphocytic leukemia (CLL) cells and disrupts several external survival pathways needed...

New finding may pave the way to the development of drugs for treating the diseaseAccording to a new study a protein crucial for the immune response appears to be a key player in the progression of a devastating form of childhood leukemia called T-cell acute lymphoblastic leukemia (T-ALL). Suppressing the activity of the protein kills the leukemic cells, the study shows, opening a potential avenue to new drugs that could prevent progression of the disease.Led by Iannis Aifantis, PhD, associate...

(Ivanhoe Newswire) -- We've all heard about the potential medical benefits of stem cells. Now, researchers have created a synthetic surface that allows stem cells to stay alive and continue reproducing for at least three months.Human pluripotent stem cells can become any other kind of body cell. These types of cells have shown great promise in treating conditions such as Parkinson's disease, multiple sclerosis and spinal cord injuries. However, one challenge faced by scientists has been...

Mushrooms are among the many foods thought to play an important role in keeping the immune system healthy. Now, Agricultural Research Service (ARS)-funded scientists have conducted an animal-model and cell-culture study showing that white button mushrooms enhanced the activity of critical cells in the body's immune system.In the United States, white button mushrooms represent 90 percent of the total mushrooms consumed.The study was conducted at the Jean Mayer USDA Human Nutrition Research...

This discovery may generate new strategies to fight serious human diseases, and devastating plant blights--including the type of blight involved in the Irish Potato Blight.A study published in the July 23 issue of Cell identifies the mechanism used by several types of common, virulent microbes to infect plants and cause devastating blights. Microbes using this infection mechanism include fungi that are currently causing wheat rust epidemics in Africa and Asia, and a class of parasitic algae,...

A research team led by scientists at the Virginia Bioinformatics Institute (VBI) at Virginia Tech has discovered a fundamental entry mechanism that allows dangerous fungal microbes to infect plants and cause disease. The discovery paves the way for the development of new intervention strategies to protect plant, and even some animal cells, from deadly fungal infections. The findings are published in the July 23 edition of the journal Cell.The researchers have revealed how special...

Immune system cells called macrophages spring into action to surround and destroy threats such as viruses or cancer cells. But sometimes the would-be protective response leads to persistent inflammation, which, in turn, can cause disease.Scientists don't know exactly how macrophages cross the line from being good cops to bad cops, but researchers at the University of Florida recently unearthed several clues about the mechanisms involved. Through the lens of two inflammation-related diseases,...

Today during the 88th General Session & Exhibition of the International Association for Dental Research, in Barcelona, Spain, presenting author J. Meyle, Justus Liebig University, Giessen, Germany, will present an abstract titled "P. gingivalis Infection and Immune Evasion of Oral Carcinomas."Meyle and his team are investigating the relationship of oral cancers and periodontal disease. They achieved results by infecting cell carcinoma cells SCC-25 with Porphyromonas gingivalis...

Journal PLoS Biology reports novel findings by Florida State and London researchersA landmark study by Florida State University biologists, in collaboration with scientists in Britain, is the first to identify a life-or-death "cell competition" process in mammalian tissue that suppresses cancer by causing cancerous cells to kill themselves.Central to their discovery was the researchers' identification of "Mahjong" "“"“ a gene that can determine the winners of the...

p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal of myeloid precursorsNew research by scientists at Cold Spring Harbor Laboratory (CSHL) has illuminated in fine detail one of the genetic paths that leads to a particularly aggressive form of leukemia.CSHL Professor Scott W. Lowe. Ph.D., an Investigator of the Howard Hughes Medical Institute, led a team of scientists who wanted to know more about how the absence of an important tumor-suppressing protein called p53...