Latest TAT Stories

Scientists have known for more than a decade that a protein associated with the HIV virus is good at crossing cell membranes, but they didn't know how it worked. A multidisciplinary team from the University of Illinois has solved the mystery, and their findings could improve the design of therapeutic agents that cross a variety of membrane types.A paper describing their findings appears this month in Angewandte Chemie.The TAT protein transduction domain of the HIV virus has some remarkable...

Researchers seek to deny HIV its safe havens in the human bodyA drug already used to treat parasitic infections, and once looked at for cancer, also attacks the human immunodeficiency virus (HIV) in a new and powerful way, according to research published today online in the open access journal Retrovirology. Past research has established that HIV has "learned" to hide out in certain human cells where it is safe from the body's counterattack, cells that come to serve as viral reservoirs....

DES PLAINES, Ill., July 17 /PRNewswire-FirstCall/ -- Since the first diagnostic test for the human immunodeficiency virus (HIV) came on the market in 1985, public health authorities have been concerned about HIV's ability to mutate and create new strains of subtypes that may elude detection. While many of the variant strains of HIV are not as prevalent in the United States as other countries, studies suggest that the influx of immigrants from countries where these strains are more common is...

By Maggie Fox, Health and Science Correspondent DENVER (Reuters) - Which particular kind of HIV virus an AIDS patient has may be more important than other factors in how quickly death comes, U.S. and Ugandan researchers reported on Monday. They found that people infected with a clade, or subtype, of HIV called D died more quickly that those with infections from the A clade. Clade was a better predictor than viral load -- how much virus can be found in a patient's blood -- of rapid...

By Maggie Fox, Health and Science Correspondent DENVER (Reuters) - Which particular kind of HIV virus an AIDS patient has may be more important than other factors in how quickly death comes, U.S. and Ugandan researchers reported on Monday. They found that people infected with a clade, or subtype, of HIV called D died more quickly that those with infections from the A clade. Clade was a better predictor than viral load -- how much virus can be found in a patient's blood -- of rapid...

By Maggie Fox, Health and Science CorrespondentDENVER (Reuters) - Which particular kind of HIV virus an AIDS patient has may be more important than other factors in how quickly death comes, U.S. and Ugandan researchers reported on Monday.They found that people infected with a clade, or subtype, of HIV called D died more quickly that those with infections from the A clade.Clade was a better predictor than viral load -- how much virus can be found in a patient's blood -- of rapid death from...

PHILADELPHIA, PA -- A novel protein, p27SJ, extracted from a callus culture of the St. John's wort plant (Hypericum perforatum) suppresses HIV-1 expression and inhibits its replication, according to researchers at Temple University School of Medicine's department of neuroscience and Center for Neurovirology (CNV). Their findings, "p27SJ, a novel protein in St. John's wort, that suppresses expression of HIV-1 genome," will be published online in the Oct. 27 issue of Gene Therapy...

Researchers studying the evolution of the human immunodeficiency virus (HIV) in the brain have found that the body's own defenses may cause HIV-related dementia. Publishing in the Sept. 2005 issue of the Journal of Virology, the researchers show that HIV in the temporal lobe mutates at a rate 100 times faster than in other parts of the body, triggering white blood cells to continually swarm to attack the infection. The associated overcrowding and inflammation appear to cause the dementia....

Random fluctuations in gene expression can influence the fates of cells infected with human immunodeficiency virus (HIV) far more than previously thought, according to new research from Howard Hughes Medical Institute (HHMI) researchers at the University of California, Berkeley. By combining experimental and computational studies of HIV's replication cycle, the researchers found evidence that the virus may become latent in some cells by harnessing the random molecular behavior of the cell....