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Latest Tau protein Stories

2012-02-03 09:18:50

Researchers tease out toxic role of tau oligomers One of the most distinctive signs of the development of Alzheimer's disease is a change in the behavior of a protein that neuroscientists call tau. In normal brains, tau is present in individual units essential to neuron health. In the cells of Alzheimer's brains, by contrast, tau proteins aggregate into twisted structures known as "neurofibrillary tangles." These tangles are considered a hallmark of the disease, but their precise role in...

2012-02-02 09:16:42

Findings open new opportunities for studying Alzheimer´s and testing potential therapies For decades, researchers have debated whether Alzheimer's disease starts independently in vulnerable brain regions at different times, or if it begins in one region and then spreads to neuroanatomically connected areas. A new study by Columbia University Medical Center (CUMC) researchers strongly supports the latter, demonstrating that abnormal tau protein, a key feature of the neurofibrillary...

2011-11-02 09:06:07

Neurofibrillary tangles — odd, twisted clumps of protein found within nerve cells — are a pathological hallmark of Alzheimer's disease. The tangles, which were first identified in the early 1900s by German psychiatrist and neuropathologist Aloysius Alzheimer, are formed when changes in a protein called tau cause it to aggregate in an insoluble mass in the cytoplasm of cells. Normally, the tau protein is involved in the formation of microtubules, hollow filaments that provide cells...

2011-11-01 15:25:41

New research in the FASEB Journal suggests that tangles, 1 of the 2 main Alzheimer's markers, consist of proteins called neurofilaments and vimentin as well as the tau protein Scientists from the National Institutes of Health in the United States have made an important discovery that should forever change the scope and direction of Alzheimer's research. Specifically, they have discovered that the protein tangles which are a hallmark of the disease involve at least three different proteins...

2011-07-25 08:45:00

HOBOKEN, NJ, July 25, 2011 /PRNewswire/ - Anavex Life Sciences Corp. ("Anavex") (OTCBB: AVXL) is pleased to provide a summary of the first of two poster presentations at the Alzheimer's Association International Conference (AAIC) held in Paris, entitled "The novel aminotetrahydrofuran derivative ANAVEX 2-73 attenuated GSK-3beta and Tau hyperphosphorylation in a nontransgenic Alzheimer's disease model in mice." Researchers injected oligomeric amyloid 25-35 fragments into the brain...

2011-06-29 18:13:55

Overexpression of gene is linked with Alzheimer's disease and down syndrome Chronic stress has long been linked with neurodegeneration. Scientists at USC now think they may know why. The study, which has tremendous implications for understanding and treating Alzheimer's disease, was published in the June issue of The FASEB Journal (the Journal of the Federation of American Societies for Experimental Biology). Corresponding author Kelvin J. A. Davies, the James E. Birren Chair at the USC Davis...

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2011-06-07 09:33:44

In what they are calling a new direction in the study of Alzheimer's disease, UC Santa Barbara scientists have made an important finding about what happens to brain cells that are destroyed in Alzheimer's disease and related dementias. The results are published in the online version of The Journal of Biological Chemistry. Stuart Feinstein, professor of Molecular, Cellular and Developmental Biology, senior author, and co-director of UCSB's Neuroscience Research Institute, explained: "With...

2011-05-26 20:45:04

Stress hormones lead to Alzheimer-like protein modifications Stress promotes neuropathological changes that are also seen in Alzheimer's disease. Scientists from the Max Planck Institute of Psychiatry in Munich have discovered that the increased release of stress hormones in rats leads to generation of abnormally phosphorylated tau protein in the brain and ultimately, memory loss. Protein deposits in nerve cells are a typical feature of Alzheimer's disease: the excessive alteration of the tau...

2011-04-02 02:06:35

New biomarker for tau-related brain disorders? Researchers at the University of Pennsylvania School of Medicine have determined that a well-known chemical process called acetylation has a previously unrecognized association with one of the biological processes associated with Alzheimer's disease and related disorders. The findings were published in the latest issue of Nature Communications. Tau is one of the primary disease proteins associated with a suite of neurodegenerative diseases. Tau...

2011-02-16 15:36:53

Max Planck study raises hopes for the development of effective therapies Amyloid-beta and tau protein deposits in the brain are characteristic features of Alzheimer disease. The effect on the hippocampus, the area of the brain that plays a central role in learning and memory, is particularly severe. However, it appears that the toxic effect of tau protein is largely eliminated when the corresponding tau gene is switched off. Researchers from the Max Planck Research Unit for Structural...


Word of the Day
pungle
  • To take pains; labor assiduously with little progress.
This word comes from the Spanish 'pongale,' put it.
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