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Latest Tau protein Stories

2011-02-16 15:28:08

LA BioMed study finds damaging accumulation of tau proteins removed Increasing puromycin-sensitive aminopeptidase, the most abundant brain peptidase in mammals, slowed the damaging accumulation of tau proteins that are toxic to nerve cells and eventually lead to the neurofibrillary tangles, a major pathological hallmark of Alzheimer's disease and other forms of dementia, according to a study published online in the journal, Human Molecular Genetics. Researchers found they could safely...

2010-12-23 02:09:04

A new study is unraveling the earliest events associated with neurodegenerative diseases characterized by abnormal accumulation of tau protein. The research, published by Cell Press in the December 22 issue of the journal Neuron, reveals how tau disrupts neuronal communication at synapses and may help to guide development of therapeutic strategies that precede irreversible neuronal degeneration. Tau normally contributes to the supportive framework of proteins in the cell. It is well...

2010-12-03 15:42:52

Study suggests memory-destroying tau tangles proliferate when Hsp27 regulation is compromised Dynamic regulation of the chaperone protein Hsp27 was required to get rid of abnormally accumulating tau in the brains of mice genetically modified to develop the memory-choking tau tangles associated with Alzheimer's disease, a University of South Florida-led study found. Researchers at the USF Health Byrd Alzheimer's Institute demonstrated that the effective switching of Hsp27 between its active...

2010-11-24 10:11:59

Scientists from Berlin, Bonn and Dundee show in animal models that the diabetes drug Metformin has an effect against one of the main causes of the Alzheimer's disease. Bonn, 24th November 2010. Metformin, a drug used in type 2-diabetes might have the potential to also act against Alzheimer's disease. This has been shown in a study from scientists of the German Center for Neurodegenerative Diseases (DZNE), the University of Dundee and the Max-Planck-Institute for Molecular Genetics. The...

2010-11-17 17:34:55

Researchers describe their scientific presentations for neuroscience 2010 Researchers from Georgetown University Medical Center's departments of neuroscience, pharmacology, physiology, biochemistry, molecular and cellular biology, and the interdisciplinary program of neuroscience will present more than 50 research abstracts at the 40th Annual Meeting of the Society for Neuroscience Nov. 13th through the 17th in San Diego. Modulation of temporal relationships between default mode and...

2010-11-11 09:17:00

NEW YORK, Nov. 11, 2010 /PRNewswire/ -- Oligomerix, Inc. today announced the receipt of a two-year Small Business Innovation Research (SBIR) Phase II grant for $1.6M from the National Institute on Aging, National Institutes of Health (NIH), for a program to discover small molecules and antibodies targeting tau protein oligomers in the development of disease modifying therapeutics for Alzheimer's disease. Compound libraries will be screened at the Michigan High Throughput Screening Center...

2010-10-19 12:22:54

Finding a drug that can cross the blood-brain barrier is the bane of drug development for Alzheimer's disease and other neurological disorders of the brain. A new Penn study, published this week in the Journal of Neuroscience, has found and tested in an animal model of Alzheimer's disease a class of drug that is able to enter the brain, where it stabilizes degenerating neurons and improves memory and learning. In the normal brain, the protein tau plays an important role in stabilizing...

2010-10-07 13:32:40

Cells that help to protect the central nervous system may also contribute to pathological changes in the brain. New research, published by Cell Press in the October 7th issue of the journal Neuron, provides mechanistic insight into a link between the immune system and neurodegenerative disorders like Alzheimer's disease that are associated with abnormal accumulation of tau protein. Tau is a protein found inside of neurons that acts almost like a skeleton, providing a supportive framework for...

2010-09-22 17:33:32

A new study uncovers a protein modification that may contribute to the formation of neuron-damaging neurofibrillary tangles in the human brain. The research, published by Cell Press in the September 23 issue of the journal Neuron, may lead to new strategies for treatment of neurodegenerative diseases that result from pathological aggregation of tau protein. Tau protein is common in the central nervous system where it helps to stabilize microtubules that form the neuronal cytoskeleton. Tau...

2010-09-22 14:38:49

Tau acetylation may contribute to Alzheimer's disease and other dementias Scientists at the Gladstone Institute of Neurological Disease (GIND) have uncovered new approaches to reduce toxic proteins in Alzheimer's disease (AD) and other neurodegenerative diseases. The results might lead to new treatments for these diseases. "We examined a protein called tau that has been strongly implicated in Alzheimer's disease," said Li Gan, PhD, senior author on the study. "Tau forms toxic protein...


Word of the Day
malpais
  • The ragged surface of a lava-flow.
'Malpais' translates from Spanish as 'bad land.'