Latest TB Stories
Special edition to mark World TB day maps new issues and approaches to curbing spread of infection During the 1930s, dedicated sanitaria and invasive surgery were commonly prescribed for those with the infection - usually caused by Mycobacterium tuberculosis, which the editors describe as "the most successful human pathogen of all time." TB often lies dormant with no symptoms, but in a proportion of cases, becomes active, predominantly attacking the lungs. But it can also affect the...
[ Watch the Video: Discussing New Tuberculosis Vaccine Trials ] Lee Rannals for redOrbit.com - Your Universe Online A new vaccine considered to be the most advanced for tuberculosis (TB) among more than a dozen now in trials has failed its study. Researchers said they were disappointed by the results of the study, which showed that the vaccine offered little to no protection at all from TB. Nearly 3,000 babies in South Africa took part in the study, all of whom had already been...
A diagnostic test for tuberculosis (TB) can accurately and quickly detect both TB and drug-resistant strains, according to a new study. The authors of a new systematic review assessing the diagnostic accuracy of the Xpert® MTB/RIF test published in The Cochrane Library say their study can provide timely advice for clinicians and policymakers in countries where TB is a major public health problem. Millions of people develop TB every year. Around 13% of cases occur in people living with HIV...
TITUSVILLE, N.J., Dec. 31, 2012 /PRNewswire/ -- Janssen Therapeutics, Division of Janssen Products, LP, today announced the U.S. Food and Drug Administration (FDA) has granted accelerated approval to SIRTURO(TM) (bedaquiline) Tablets for the treatment of pulmonary multi-drug resistant tuberculosis (MDR-TB) as part of combination therapy in adults. The accelerated approval is based on the surrogate endpoint of time to sputum culture conversion. "SIRTURO(TM) was first discovered in our...
4'-Phosphopantetheinyl Transferase PptT, a new drug target required for mycobacterium tuberculosis growth and persistence in vivo One third of the world is infected with the bacterium that causes tuberculosis (TB), a disease that is increasingly difficult to treat because of wide spread resistance to available drugs. Researchers from the Institute of Pharmacology and Structural Biology (CNRS, Université de Toulouse) in Toulouse (France) have identified a fresh target to develop new drugs...
Lee Rannals for redOrbit.com - Your Universe Online Over half of couches in homes have potentially toxic or chemical flame retardants, according to a study published in the Environmental Science & Technology journal. Researchers tested for 49 flame retardant chemicals in household dust, which was the largest number of flame retardants ever tested in a peer-reviewed study. The researchers detected 44 flame retardant chemicals, 36 of which were found in at least 50 percent of the...
A rapid test for tuberculosis (TB) could help to reduce TB deaths, improve TB treatment, and also offer reasonably good value for money if introduced in southern Africa, an area that has high rates of HIV and a type of TB that is resistant to some drugs (multi-drug resistant TB), according to a study published in this week's PLOS Medicine. The World Health Organization (WHO) recently recommended the use of a new diagnostic test for TB (the Xpert MTB/RIF test), which can show a result...
Weill Cornell Medical College announced today that it is a Grand Challenges Explorations winner, an initiative funded by the Bill & Melinda Gates Foundation. Researchers at Weill Cornell have been awarded three research grants totaling more than $1.5 million. Weill Cornell's Dr. Juan R. Cubillos-Ruiz, a postdoctoral research associate in medicine in the laboratory of Dean Dr. Laurie H. Glimcher, will pursue an innovative global health and development research project titled, "Tailored...
A study led by The University of Manchester has demonstrated that new technology that can analyze millions of gene sequences in a matter of seconds is an effective way to quickly and accurately identify diseases in skeletons. Professor Terry Brown, working in partnership with Professor Charlotte Roberts from Durham University, used a next generation sequencing approach, including hybridization capture technology, to identify tuberculosis genes in a 19th century female skeleton found in a...
Phase IIb Proof of Concept Trial Planned for Kenya, India and South Africa ROCKVILLE, Md., Oct. 10, 2012 /PRNewswire-USNewswire/ -- Aeras announces that it has signed an agreement with GlaxoSmithKline Vaccines, S.A. (GSK) to jointly advance the clinical development of an investigational tuberculosis (TB) vaccine containing GSK's proprietary M72 antigen and AS01(E)(*) adjuvant. This novel research and resource-sharing agreement between the largest non-profit TB vaccine biotech and...
