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Latest Telomerase Stories

2012-06-19 14:03:05

UCLA biochemists have mapped the structure of a key protein—RNA complex that is required for the assembly of telomerase, an enzyme important in both cancer and aging. The researchers found that a region at the end of the p65 protein that includes a flexible tail is responsible for bending telomerase's RNA backbone in order to create a scaffold for the assembly of other protein building blocks. Understanding this protein, which is found in a type of single-celled organism that lives...

2012-06-15 12:00:47

Preclinical study links aging and cancer, with lethal host metabolism in the tumor microenvironment It has long been known that cancer is a disease of aging, but a molecular link between the two has remained elusive. Now, researchers at the Kimmel Cancer Center at Jefferson (KCC) have shown that senescence (aging cells which lose their ability to divide) and autophagy (self-eating or self-cannibalism) in the surrounding normal cells of a tumor are essentially two sides of the same coin,...

2012-05-25 09:53:58

Researchers at NYU School of Medicine have, for the first time, identified a single gene that simultaneously controls inflammation, accelerated aging and cancer. "This was certainly an unexpected finding," said principal investigator Robert J. Schneider, PhD, the Albert Sabin Professor of Molecular Pathogenesis, associate director for translational research and co-director of the Breast Cancer Program at NYU Langone Medical Center. "It is rather uncommon for one gene to have two very...

2012-05-15 09:33:03

Mouse lifespan extended up to 24 percent with a single treatment A number of studies have shown that it is possible to lengthen the average life of individuals of many species, including mammals, by acting on specific genes. To date, however, this has meant altering the animals' genes permanently from the embryonic stage — an approach impracticable in humans. Researchers at the Spanish National Cancer Research Centre (CNIO), led by its director María Blasco, have proved...

2012-04-30 05:26:23

(Ivanhoe Newswire) -- In today's society, kids already act and look older than they are. Recent research has proved that the DNA of 10-year-olds who have experienced violence at a young age are found to show wear and tear normally associated with aging. "This is the first time it has been shown that our telomeres can shorten at a faster rate even at a really young age, while kids are still experiencing stress," Idan Shalev, a post-doctoral researcher in psychology and neuroscience at the...

Children Age Faster When Exposed To Violence And Bullying
2012-04-25 10:07:00

Researchers have found that violence in the lives of children can cause changes in their DNA equivalent to seven to 10 years of premature aging. Scientists measured this cellular aging by studying the ends of children´s chromosomes, called telomeres. Telomeres are DNA sequences that act like the plastic tips on shoelaces, which prevent the DNA in chromosomes from unraveling. Each time a cell divides, the telomeres become shorter until a cell dies when it can´t divide anymore,...

2012-03-26 11:03:13

Few molecules are more interesting than DNA–except of course RNA. After two decades of research, that "other macromolecule" is no longer considered a mere messenger between glamorous DNA and protein-synthesizing machines. We now know that RNA has been leading a secret life, regulating gene expression and partnering with proteins to form catalytic ribonucleoprotein (RNP) complexes. One of those RNPs is telomerase, an enzyme that maintains chromosome integrity. In the March 25, 2012,...

2012-03-21 21:37:37

Worm model of back-up telomere repair strategy could speed identification of anti-cancer drugs Rapidly dividing cancer cells are skilled at patching up damage that would stop normal cells in their tracks, including wear and tear of telomeres, the protective caps at the end of each chromosome. Loss of telomeres forces cells out of the dividing game and into a growth arrest state called "senescence," but cancer cells evade this by employing an enzyme called telomerase to extend eroded...


Word of the Day
omphalos
  • The navel or umbilicus.
  • In Greek archaeology: A central boss, as on a shield, a bowl, etc.
  • A sacred stone in the temple of Apollo at Delphi, believed by the Greeks to mark the 'navel' or exact center-point of the earth.
'Omphalos' comes from the ancient Greek.
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