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Latest Telomere Stories

2009-10-05 08:43:00

SAN FRANCISCO, Oct. 5 /PRNewswire-USNewswire/ -- Molecular biologist Elizabeth H. Blackburn, PhD, 60, of the University of California, San Francisco, today was named to receive the 2009 Nobel Prize in Physiology or Medicine. Blackburn shares the award with Carol W. Greider of Johns Hopkins University School of Medicine and Jack W. Szostak of Harvard Medical School. The scientists discovered an enzyme that plays a key role in normal cell function, as well as in cell aging and most...

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2009-10-05 12:30:00

An American team of researchers was awarded the Nobel Medicine Prize on Monday for their discovery in the process of cellular aging. Elizabeth Blackburn, Carol Greider and Jack Szostak were chosen to share the award for their role in showing "how chromosomes are protected by telomeres and the enzyme telomerase," the Nobel Assembly said Monday. The team showed how chromosomes can be copied in a complete way during cell divisions and how they can be protected against degradation. "The Nobel...

2009-09-29 09:00:00

ROYAL PALM BEACH, Fla., Sept. 29 /PRNewswire/ -- The first anti-aging doctor to offer TA-65 treatment in the U.S., has discovered a way to apply similar technology to skin care. TA-65 is the newest and most dramatic technology in the world of life extension. It is the only commercially available product that lengthens human telomeres - the protective tips that cap the ends of your DNA. Each time your cells divide, your telomeres get shorter. When your telomeres run down, cell division...

2009-09-18 07:37:58

The Stowers Institute's Baumann Lab has demonstrated how human cells protect chromosome ends from misguided repairs that can lead to cancer. The work, published in The EMBO Journal, a publication of the European Molecular Biology Organization, follows the team's 2007 in vitro demonstration of the role of the hRAP1 protein in preventing chromosome ends from being fused to new DNA breaks. Chromosomes are linear. Their ends (called telomeres) should look like DNA breaks to the proteins that...

2009-09-01 13:06:37

A process that limits the number of times a cell divides works much differently than had been thought, opening the door to potential new anticancer therapies, researchers at UT Southwestern Medical Center report in the Aug. 7 issue of the journal Cell.Most cells in the human body divide only a certain number of times, via a countdown mechanism that stops them. When the controlling process goes wrong, the cells divide indefinitely, contributing to cancer growth.The number of times a cell...

2009-08-31 15:05:17

A team of researchers from The Wistar Institute have shown that a large non-coding RNA in mammals and yeast plays a central role in helping maintain telomeres, the tips of chromosomes that contain important genetic information and help regulate cell division. Since this RNA also facilitates the formation of DNA at telomeres"”a process that can protect aging cells and destabilize tumor cells"”manipulating its expression may be useful in treating cancer and other diseases.The steady...

2009-08-13 14:30:00

Scientists show 'Swiss Army knife' has surprising functions and a possible tie to metastatic cancerA protein specialist that opens the genomic door for DNA repair and gene expression also turns out to be a multi-tasking workhorse that protects the tips of chromosomes and dabbles in a protein-destruction complex, a team lead by researchers at The University of Texas M. D. Anderson Cancer Center reports in the Aug. 13 edition of Molecular Cell."Instead of being a really important tool dedicated...

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2009-08-05 09:20:00

As the body creates antibodies to fight invaders, a three-protein DNA repair complex called MRN is crucial for a normal gene-shuffling process to proceed properly, University of Michigan research shows.The discoveries in mice, published online this week in Nature Structural and Molecular Biology, advance understanding of the immune system and shed light on how B-cell lymphoma and some other cancers may begin.U-M scientists found that:When one protein in the MRN complex, Mre11, is absent,...

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2009-07-10 09:45:00

Telomeres, the repetitive sequences of DNA at the ends of linear chromosomes, have an important function: They protect vulnerable chromosome ends from molecular attack. Researchers at Rockefeller University now show that telomeres have their own weakness. They resemble unstable parts of the genome called fragile sites where DNA replication can stall and go awry. But what keeps our fragile telomeres from falling apart is a protein that ensures the smooth progression of DNA replication to the...

2009-07-01 13:56:06

A molecule called telomerase, best known for enabling unlimited cell division of stem cells and cancer cells, has a surprising additional role in the expression of genes in an important stem cell regulatory pathway, say researchers at the Stanford University School of Medicine. The unexpected finding may lead to new anticancer therapies and a greater understanding of how adult and embryonic stem cells divide and specialize."Telomerase is the factor that accounts for the unlimited division of...