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Latest Temsirolimus Stories

2014-01-04 23:01:12

Scientists in Japan and Austria say the kinase inhibitor temsirolimus stops mesothelioma growth in two different ways. Raleigh, NC (PRWEB) January 04, 2014 A new study published in the journal Oncology Reports and detailed by Surviving Mesothelioma suggests that temsirolimus, a kinase inhibitor used to treat advanced renal cell carcinoma (RCC), may offer a promising new way to treat malignant pleural mesothelioma. The group studied temsirolimus by itself and in combination with the...

2012-05-17 09:28:23

A phase I clinical trial examining the safety of combining temsirolimus and capecitabine in advanced malignancies suggests the two agents can be given safely to patients. In addition, the Georgetown Lombardi Comprehensive Cancer Center researchers conducting the study in cancer patients whose tumors have resisted multiple treatments say the combination demonstrates "promising evidence" of disease control and should be studied in a phase II trial. Their clinical findings and additional data...

2012-05-02 15:07:00

IDIBELL researchers discover that combining two mTOR inhibitors cause the regression of hepatocellular carcinoma The combination of two inhibitors of protein mTOR stops the growth of primary liver cancer and destroys tumor cells, according to a study by researchers of the Group of Metabolism and Cancer at Bellvitge Biomedical Research Institute (IDIBELL). The study results are been published on the online edition of the journal Science Translational Medicine. Primary liver cancer or...

2012-04-02 15:53:36

Aberrations in translation regulators associated with hormone receptor-positive disease survival Four proteins involved in translation, the final step of general protein production, are associated with poor prognosis in hormone-receptor-positive breast cancer when they are dysregulated, researchers reported at the AACR Annual Meeting 2012. All of the aberrantly activated translational proteins are regulated by the PI3K/mTOR molecular signaling pathway, which has been implicated in...

2012-02-29 09:26:37

(Ivanhoe Newswire) — Researchers have discovered how a protein "master regulator" goes awry, leading to metastasis, the fatal step of cancer. The protein mTOR is a "master regulator" of human protein synthesis. It helps normal cells sense nutrients and control cell growth and metabolism. But in many forms of cancer, this process goes awry, and mTOR reprograms normal cells to aberrantly divide, invade and metastasize. In the human body, mTOR is a molecular sensor that helps cells...

2011-10-28 13:14:11

mTOR shown to play key role in the process Even yeast understand austerity. A finely tuned system evolved early on to help cells survive in a world where good times come as fast as they go. The system, a molecular switch found in organisms from yeast to humans, involves a nutrient-sensing protein that turns growth on in times of plenty and shuts it off when times are lean. New work from the lab of Wenyi Wei, PhD, an investigator in the Department of Pathology at Beth Israel Deaconess...

2011-08-08 19:46:18

Drug found to interact with P-glycoprotein An early phase multiple myeloma trial has unexpectedly revealed that the drug lenalidomide interacts with another protein in cells that affect its dose level in the body, say researchers at the Ohio State University Comprehensive Cancer Center "“ Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC "“ James) who conducted the study. Lenalidomide is an anti-inflammatory drug, and more than 390 clinical trials...


Word of the Day
monteith
  • A large punch-bowl of the eighteenth century, usually of silver and with a movable rim, and decorated with flutings and a scalloped edge. It was also used for cooling and carrying wine-glasses.
  • A kind of cotton handkerchief having white spots on a colored ground, the spots being produced by a chemical which discharges the color.
This word is possibly named after Monteith (Monteigh), 'an eccentric 17th-century Scotsman who wore a cloak scalloped at the hem.'
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