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Latest Tetrapyrroles Stories

2011-05-26 20:59:54

Researchers have discovered a tiny protein without which the soil and lab-dwelling worm C. elegans can't deliver iron-rich heme taken in from their diets to the rest of their bodies or to their developing embryos. The finding reported in the May 27th issue of the journal Cell, a Cell Press publication, offers important insight into the transport of the essential ingredient in worms and other animals, including humans. Researchers say it also suggests a strategy for the development of drugs...

2011-05-26 20:58:20

Using a tiny bloodless worm, University of Maryland Associate Professor Iqbal Hamza and his team have discovered a large piece in the puzzle of how humans, and other organisms, safely move iron around in the body. The findings, published in the journal Cell, could lead to new methods for treating age-old scourges - parasitic worm infections, which affect more than a quarter of the world's population, and iron deficiency, the world's number one nutritional disorder. Using C. elegans, a common...

2011-01-30 23:59:00

AMSTERDAM, The Netherlands, January 31, 2011 /PRNewswire-FirstCall/ -- Amsterdam Molecular Therapeutics (Euronext: AMT), a leader in the field of human gene therapy, announced today that the European Union (EU) has finalized a EUR 3.3 million grant to the AIPGENE consortium, of which AMT is a member, for the development of a gene therapy product for Acute Intermittent Porphyria (AIP). AIP is a severe and progressive disease caused by the inability of the body to produce the heme protein,...

2011-01-10 14:35:18

New insights from the nano world The mechanism for binding oxygen to metalloporphyrins is a vital process for oxygen-breathing organisms. Understanding how small gas molecules are chemically bound to the metal complex is also important in catalysis or the implementation of chemical sensors. When investigating these binding mechanisms, scientists use porphyrin rings with a central cobalt or iron atom. They coat a copper or silver support surface with these substances. An important...

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2010-09-09 08:25:00

A research team led by Cary Pirone from the Department of Biological Sciences at Florida International University has identified bilirubin in the popular Bird of Paradise plant. The breakthrough study, published in the September 2010 issue of the American Society for Horticultural Science's journal HortScience, provides new insights into color production in this iconic tropical plant. Previously thought to be an "animal-only" pigment, bilirubin is best known as the yellowish hue associated...

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2009-12-18 08:42:57

Scientists at Washington University have isolated a channel that shuttles the vital but vulnerable heme molecule across biological membranes In some ways a cell in your body or an organelle in that cell is like an ancient walled town. Life inside either depends critically on the intelligence of the gatekeepers. If too many barbarians sneak into town, the town may be put to the torch. And if the cellular gatekeepers can't control the flow of ions and molecules into and out of the cell, the...

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2009-09-13 07:51:40

Best known as the oxygen-carrying component of hemoglobin, the protein that makes blood red, heme also plays a role in chemical detoxification and energy metabolism within the cell. Heme levels are tightly maintained, and with good reason: Too little heme prevents cell growth and division; excessive amounts of heme are toxic. Researchers at the University of Pennsylvania School of Medicine have discovered a molecular circuit involving heme that helps maintain proper metabolism in the body,...

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2009-09-10 05:33:16

Holds promise for studying how organisms cleanse themselves of dying cells Nicholas Turro of Columbia University, Bernhard Krautler of the University of Innsbruck, Austria and their colleagues have found that, as chlorophyll ages and begins to disintegrate in banana peels it does not change color in the spectrum of visible light we see. Instead, it glows blue when observed under ultraviolet light. While the light show adds a level of exoticism to the fruit in our eyes, and serves to attract a...

2009-09-03 13:02:28

Oregon State University scientists say they've discovered some food compounds studied for an ability to prevent cancer might also be able to treat it. Researchers at the university's Linus Pauling Institute suggest some natural food compounds might be effective in working side-by-side with conventional drugs that are now used in chemotherapy. The scientists said they examined the activity of chlorophyllin and found, on a dose-by-dose basis, it was 10 times more potent at causing the death of...

2009-01-19 10:00:00

Bifera provides the energy and nutritional benefits from iron with virtually no gastrointestinal side effects and is now available without a prescription ATLANTA, Jan. 19 /PRNewswire/ -- Bifera (www.bifera.com), an over-the-counter iron supplement that offers both heme (protein-based iron) and non-heme iron (plant-based iron) is now available in stores in the United States. Unlike other iron supplements, Bifera provides two types of iron in one small pill for maximum absorption with...