Latest TGF beta Activation Stories

2012-05-03 19:28:41

Lawson research provides new insight into disease pathology In a new study from Lawson Health Research Institute, Dr. Joseph Torchia has identified a new genetic pathway influencing the spread of cancer cells. The discovery of this mechanism could lead to new avenues for treatment. Regular cell division is regulated by methylation, a series of chemical changes. Methylation modifies DNA to ensure cells divide at a healthy, balanced rate. In cancer, the methylation process is unbalanced,...

2011-11-23 14:21:24

Glioblastoma is regarded as the most malignant form of brain tumor. In many cases, neurosurgeons are not able to remove such tumors completely because of the risk of destroying too much brain tissue in the process. Moreover, it is often impossible to identify all the fine extensions by which the tumor spreads into surrounding healthy tissue. To at least slow down the growth of tumor cells that have remained in the head, almost all glioblastoma patients are treated by radiotherapy after...

2010-12-31 12:21:01

(Ivanhoe Newswire) "“ Many mechanisms change the activity of genes. Epigenetics determine when genes are turned on and off, and these epigenetics allow for cells to become cancerous. This was especially seen in ovarian cancer. Researchers at the Duke Cancer Institute have found evidence of epigenetics at work on a genome-wide scale in cases of ovarian cancer. One major biological signaling pathway in particular was found to contain many genes influenced by DNA methylation, a mechanism...

2010-06-10 15:28:14

Several years ago, Dr. Arthur Beaudet, Baylor College of Medicine's chair of molecular and human genetics, was surprised to find that mice that lacked a protein called E-selectin ligand-1 were shorter than normal. He and his colleagues were hoping that the protein was involved in cell adherence, but instead their mice had a form of dwarfism. They turned the mice and their data over to Dr. Brendan Lee, a professor of molecular and human genetics at BCM, and an expert in the development of...

2009-05-19 14:20:17

Vanderbilt-Ingram Cancer Center researchers have uncovered a gene signature that may help predict clinical outcomes in certain types of breast cancer. In the Journal of Clinical Investigation, Harold (Hal) Moses, M.D., and colleagues report that this gene signature "“ which is associated with the transforming growth factor-beta (TGF-ÃŽ²) signaling pathway "“ correlates with reduced relapse-free survival in patients with breast cancer, especially in those with...

Word of the Day
  • A cloth or covering, more or less ornamented, laid over the saddle or furniture of a horse, especially of a sumpter-horse or horse of state.
  • Clothing, especially sumptuous clothing; equipment; outfit.
  • To cover with a caparison, as a horse.
  • To dress sumptuously; adorn with rich dress.
This word ultimately comes from the Medieval Latin 'cappa,' cloak.