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Latest TGF beta Stories

2011-12-06 23:14:36

Reseach presented at ASCB annual meeting Reproductive and somatic aging use different molecular mechanisms that show little overlap between the types of genes required to keep oocytes healthy and the genes that generally extend life span, according to Coleen Murphy, Ph.D., of Princeton University, who described her new findings on oocyte aging at the American Society for Cell Biology Annual Meeting Dec. 6 in Denver. The different genetic pathways help explain why a woman's fertility...

2011-11-23 14:21:24

Glioblastoma is regarded as the most malignant form of brain tumor. In many cases, neurosurgeons are not able to remove such tumors completely because of the risk of destroying too much brain tissue in the process. Moreover, it is often impossible to identify all the fine extensions by which the tumor spreads into surrounding healthy tissue. To at least slow down the growth of tumor cells that have remained in the head, almost all glioblastoma patients are treated by radiotherapy after...

2011-10-27 15:37:17

FINDINGS: Whitehead Institute scientists have determined that master transcription factors determine the genes regulated by key signaling pathways. In this way, signaling pathways are targeted to genes that are most relevant to each cell type and tailor gene expression to control cell state, growth, differentiation, and death. RELEVANCE: When signaling pathways operate properly, a cell receives instructions from its neighbors and the environment that tweak gene expression and control the...

2011-08-29 13:04:48

Ever since scientists first began growing human cells in lab dishes in 1952, they have focused on improving the chemical soup that feeds the cells and helps regulate their growth. But surfaces also matter, says Laura Kiessling, a professor of chemistry at the University of Wisconsin-Madison, who observes that living cells are normally in contact with each other and with a structure called the extracellular matrix, not just with the dissolved chemicals in their surroundings. "Soluble...

2011-08-29 13:03:27

With stem cells so fickle and indecisive that they make Shakespeare's Hamlet pale by comparison, scientists today described an advance in encouraging stem cells to make decisions about their fate. The technology for doing so, reported here at the 242nd National Meeting & Exposition of the American Chemical Society (ACS), is an advance toward using stem cells in "regenerative medicine" – to grow from scratch organs for transplants and tissues for treating diseases. "Stem cells...

2011-06-09 23:27:12

Whitehead Institute researchers have identified signals from breast epithelial cells that can induce those cells to transition to and maintain a mesenchymal and stem cell-like cell state that imbues both normal and cancer cells with a greater ability to migrate and self-renew. Interrupting these signals strips the cells of the migratory, invasive and self-renewal abilities used by cancer stem cells to seed new tumors. "Stem cells are important in both cancers and normal tissues. On the one...

2011-05-02 20:47:36

Scientists at Johns Hopkins have shown in laboratory experiments in mice that blocking the action of a signaling protein deep inside the heart's muscle cells blunts the most serious ill effects of high blood pressure on the heart. These include heart muscle enlargement, scar tissue formation and loss of blood vessel growth. Specifically, the Johns Hopkins team found that their intervention halted transforming growth factor beta (TGF-beta) secretion at a precise location called cell receptor...

2011-02-28 15:01:31

In an interesting bit of scientific serendipity, researchers at North Carolina State University have found that a chemical compound useful for studying the origins of intestinal birth defects may also inhibit the growth and spread of cancerous tumors. During the screening of chemical compounds created by NC State chemist Dr. Alex Deiters, developmental biologist Dr. Nanette Nascone-Yoder found one of particular interest to her research: a compound that induced heterotaxia, a disordering or...

2011-02-11 21:40:03

Resistance to leptin, a protein that plays a key role in regulating metabolism and appetite, may help prevent the development of acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) in individuals with type II diabetes, according to a study conducted by researchers in Chicago. The study indicates leptin resistance, a common characteristic of diabetes, may help prevent the formation of inflexible, fibrous tissue that develops in ALI and ARDS. The findings were published...

2011-01-05 10:00:00

SAN DIEGO, Jan. 5, 2011 /PRNewswire/ -- Amira Pharmaceuticals, Inc. announced today the publication of its findings in the Journal of Pharmacology and Experimental Therapeutics (JPET) which describes the biologic effects and the characterization of AM095, a lysophosphatidic acid (LPA) receptor 1 antagonist, in various in vitro and in vivo models of fibrotic disease. "Activation of the LPA1 receptor by LPA has been implicated in a number of disease processes, including tissue fibrosis,"...


Word of the Day
malpais
  • The ragged surface of a lava-flow.
'Malpais' translates from Spanish as 'bad land.'