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Latest TGF beta Stories

2009-12-02 11:17:17

A large proportion of late-stage breast cancers that have spread to other parts of the body (metastatic breast cancers) are characterized by overexpression of the protein Mdm2. Lindsey Mayo and colleagues, at Indiana University School of Medicine, Indianapolis, have now determined what drives this increased Mdm2 expression and found that Mdm2 helps promote cancer cells take on more aggressive characteristics, making it a potential target for drugs to treat late-stage metastatic breast...

2009-10-30 07:34:04

At its most benign, the autoimmune disease scleroderma can discolor parts of the skin of its sufferers. At its most pernicious, it can thicken and harden their skin, their blood vessels, and their internal organs before, in many cases, killing them. In all its forms, scleroderma gives Dartmouth geneticist Michael Whitfield, his graduate students, and his postdoctoral researchers a sense of urgency in their search for the triggers of the chronic condition. In a study that the Journal of...

2009-10-23 13:43:48

In the last decade, advances in the understanding of genes promoting hepatic stellate cell (HSC) activation are impressive. However, there are few breakthroughs in therapeutic intervention of hepatic fibrogenesis. Efficient and well-tolerated antifibrotic drugs are lacking and current treatment of hepatic fibrosis is limited to withdrawal of the noxious agent. Research identifying innocuous antifibrotic agents is of high priority and urgently needed. Emodin is efficacious in the management of...

2009-07-27 10:35:00

The cytokine IL-9 promotes a multiple sclerosis-like disease in mice, according to a new study by Nowak et al. published online on July 13th in the Journal of Experimental Medicine. In a related Commentary, Richard Locksley discusses the molecular and genetic regulation of cytokine production by CD4+ T helper (Th) cells and the plasticity among different Th subsets. The Commentary will be published online in the Journal of Experimental Medicine on Monday, July 27th.Since the late 1980s, when...

2009-07-23 08:51:19

Dr. Yasuni Nakanuma and colleagues of Kanazawa University Graduate School of Medicine in Kanazawa, Japan have discovered that BMP-7 (bone morphogenic protein-7) is a potential new therapy for treating high blood pressure in the liver. These results are presented in the August 2009 issue of The American Journal of Pathology.Idiopathic portal hypertension (IPH) is a form of high blood pressure that often results from blockage of the peripheral veins in the liver. Cells that line blood vessels...

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2009-07-15 12:00:00

Drugs that block a growth factor receptor on brain cells may prevent epilepsy after brain damage, according to a new study appearing in the July 15 issue of The Journal of Neuroscience.Daniela Kaufer, an assistant professor of integrative biology at the University of California, Berkeley, graduate student Luisa P. Cacheaux, and their Israeli colleagues, graduate student Yaron David and neurosurgeon Alon Friedman, found that they could prevent the brain changes leading to epilepsy in rats by...

2009-07-13 16:22:31

 Physician-scientists from NewYork-Presbyterian Hospital/Weill Cornell Medical Center believe that a heightened level a certain growth factor in the blood may explain why blacks have a greater prevalence of hypertension and kidney disease compared to whites. Results from a new study are the first to show that an elevated level of a protein, called transforming growth factor B1 (TGF-B1), raises the risk of hypertension and renal disease in humans.African Americans constitute about 32...

2009-07-08 12:20:34

Researchers at the University of Alabama at Birmingham (UAB) have discovered a molecular coupling factor that helps bones grow and remodel themselves to stay strong, a finding that could lead to better bone-building therapies and new osteoporosis drugs, the researchers saidThe coupling factor is a human protein called transforming growth factor beta-1, or TGF beta-1. Previously, scientists had searched for but missed the biological link between bone growth and bone remodeling - a natural...

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2009-06-26 10:10:00

 Understanding the molecular signals that guide early cells in the embryo to develop into different organs provides insight into ways that tissues regenerate and how stem cells can be used for new therapies. With regenerated cells, researchers hope to one day fill the acute shortage in pancreatic and liver tissue available for transplantation in cases of type I diabetes and acute liver failure.Previous studies on pancreas and liver development have focused on individual molecular signals...

2009-05-19 14:20:17

Vanderbilt-Ingram Cancer Center researchers have uncovered a gene signature that may help predict clinical outcomes in certain types of breast cancer. In the Journal of Clinical Investigation, Harold (Hal) Moses, M.D., and colleagues report that this gene signature "“ which is associated with the transforming growth factor-beta (TGF-ÃŽ²) signaling pathway "“ correlates with reduced relapse-free survival in patients with breast cancer, especially in those with...