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Latest TGF beta Stories

2009-04-07 13:32:00

BOSTON, April 7 /PRNewswire-USNewswire/ -- Scientists at Schepens Eye Research Institute have found that the growth factor known as TGF-beta is essential to the health of blood vessels in the retina and that blocking it can cause retinal dysfunction. These findings, published in the April 2 issue of PLoS ONE, may have an important impact on the prevention and treatment of diseases such as diabetic retinopathy and macular degeneration. "These results are significant because they add to our...

2009-01-21 16:32:11

Researchers led by Drs. Lillian Maggio-Price and Brian Iritani at The University of Washington found that mice that lack the immune inhibitory molecule Smad3 are acutely sensitive to both bacterially-induced inflammation and cancer. They report these findings in the January 2009 issue of The American Journal of Pathology. Bacteria contribute to the development of certain cancers, in some measure, by stimulating chronic inflammation. Absence of a molecule that inhibits inflammation, Smad3, may...

2008-07-03 00:00:27

Broccoli may combat prostate cancer by altering the activity levels of genes involved in tumour growth, a ground-breaking study has shown. Scientists made the discovery after adding either peas or broccoli to the normal diets of two groups of men for a year. During the study tissue samples were removed from the men's prostate glands and analysed using "gene chip" technology to gauge the activity of thousands of genes. The results showed that a broccoli-rich diet produced changes in gene...

2008-07-01 03:00:12

By Ishihara, Hideyuki Kubota, Hisashi; Lindberg, Raija L P; Leppert, David; Gloor, Sergio M; Errede, Mariella; Virgintino, Daniela; Fontana, Adriano; Yonekawa, Yasuhiro; Frei, Karl Abstract Gliomas, particularly glioblastoma multiforme, perturb the blood-brain barrier and cause brain edema that contributes to morbidity and mortality. The mechanisms underlying this vasogenic edema are poorly understood. We examined the effects of cocultured primary cultured human glioblastoma cells and...

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2008-06-18 13:40:00

Old muscle got a shot of youthful vigor in a stem cell experiment by bioengineers at the University of California, Berkeley, setting the path for research on new treatments for age-related degenerative conditions such as muscle atrophy or Alzheimer's and Parkinson's diseases. In a new study published June 15 in an advanced online issue of the journal Nature, researchers identified two key regulatory pathways that control how well adult stem cells repair and replace damaged tissue. They then...

2007-10-09 18:00:12

ALBUQUERQUE - A group of researchers has discovered a mechanism that helps protect deer mice from hantavirus even though the rodents carry the life-threatening disease. The research could pave the way for new therapies for treating hantavirus and other so-called zoonotic diseases transmitted to humans by animals - a huge class that includes SARS, rabies, influenza and AIDS. "We are blessed with the fact that many zoonotic diseases have hosts" that are immune to ill effects of the disease,...

2007-07-03 09:17:00

By Liu, Jun Jin, Taocong; Chang, Syweren; Ritchie, Helena H; Et al Abstract We have recently reported the induction of dental pulp stem cells (DPSCs) into dentin-secreting odontoblast-like cells after stimulation by isolated dentin matrix components, thus mimicking the nature of tissue regeneration seen after tooth disease and injury. After confluency, the cells were further cultured for 21 d in the 10% fetal bovine serum (FBS) Dulbecco's modified Eagle's medium (DMEM) (control), and in...

2005-11-08 13:03:46

LONDON (Reuters) - A single protein may hold the key to turning the tide on lung cancer -- still the world's biggest cancer killer -- research published on Tuesday showed. Researchers at Vanderbilt University in Nashville found that type 2 receptors for Transforming Growth Factor-b -- a family of proteins that controls key functions such as cell growth and death -- were missing in non-small cell lung cancer victims. A check on mice injected with lung cancer cells confirmed the...

2005-07-24 18:44:47

(Melbourne, July 24) -- It started several years ago with the observation that a large group of seemingly unconnected genes were behaving differently in patients with stomach cancer. Now a multi-national research team led by the Melbourne Branch of the Ludwig Institute for Cancer Research (LICR) has joined the proverbial dots and identified a potential new target for stomach cancer therapy, according to a paper published today in the prestigious Nature Medicine journal. The paper's first...

2005-06-09 17:35:38

HANOVER, NH -- Making new strides in their ongoing effort to understand mechanisms behind the relentless growth of cancer cells, researchers at Dartmouth Medical School have found a promising key that may open doors to future treatments in pancreatic and other forms of cancer. The innovation lies in manipulating an overabundance of chemo-resistant molecules in pancreatic cancer that inactivate pathways that would normally suppress cell growth. Published in the June 10 issue of the Journal of...


Word of the Day
glogg
  • Scandinavian punch made of claret and aquavit with spices and raisins and orange peel and sugar.
This word comes from the Swedish 'glogg,' which is an alteration of 'glodgat,' mulled (wine).
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