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Latest Toll-like receptor Stories

2011-02-23 17:36:27

Vaccine scientists say their "Holy Grail" is to stimulate immunity that lasts for a lifetime. Live viral vaccines such as the smallpox or yellow fever vaccines provide immune protection that lasts several decades, but despite their success, scientists have remained in the dark as to how they induce such long lasting immunity. Scientists at the Emory Vaccine Center have designed tiny nanoparticles that resemble viruses in size and immunological composition and that induce lifelong immunity in...

2011-01-13 15:09:22

New research in the FASEB Journal suggests that the absence of intestinal toll-like receptor 2 affects gut bacteria, pointing to a new way to manage weight and intestinal problems If you are looking to lose weight in the coming year, you may need help from an unexpected place: the bacteria in your gut. That's because scientists have discovered that the bacteria living in your intestines may play a far more significant role in weight loss and gastrointestinal problems than ever imagined. In a...

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2010-11-22 06:43:34

Though it's been at least a billion years since plants and animals shared a common ancestor, they have through the eons shared a common threat in the form of microbes, including bacteria, eukaryotes and viruses. This has resulted in remarkably similar mechanisms for detecting the molecular signatures of infectious organisms that hold promise for the future treatment of infectious diseases in humans. The recognition of microbial signature molecules by host receptors is the subject of a paper...

2010-11-03 00:39:58

Researchers at the University of California, San Diego School of Medicine have discovered that a multi-tasking protein called FoxO1 has another important but previously unknown function: It directly interacts with macrophages, promoting an inflammatory response that can lead to insulin resistance and diabetes. Contrarily, it also generates a negative feedback loop that can limit damage from excessive inflammation. The findings by Jerrold M. Olefsky, MD, Associate Dean for Scientific Affairs...

2010-10-19 15:55:39

High fat diets cause a dramatic immune system overreaction to sepsis, a condition of systemic bacterial infection. An experimental study in mice, published in the open access journal BMC Physiology, has shown that a diet high in saturated fat, sugars and cholesterol greatly exaggerates the inflammatory response to sepsis. Chantal Rivera, PhD Associate Professor of Molecular and Cellular Physiology at Louisiana State University Health Sciences Center-Shreveport, said that "Mortality due to...

2010-10-12 18:29:05

A pregnant woman's immune response to viral infections may induce subtle neurological changes in the unborn child that can lead to an increased risk for neurodevelopmental disorders including schizophrenia and autism. Research published in the online journal mBio® provides new insights into how this may happen and suggests potential strategies for reducing this risk. "Infection during pregnancy is associated with increased risk of damage to the developing nervous system....

2010-07-16 13:50:55

Today during the 88th General Session & Exhibition of the International Association for Dental Research, in Barcelona, Spain, S. Offenbacher will present an abstract titled "Mucosal Gene Expression and Salivary Proteomic Analysis of Candidiasis-Associated Denture-Stomatitis." The goal of the study was to compare whole-transcriptome, mucosal gene expression in Candida albicans (a parasitic fungus that can infect the mouth) associated chronic denture stomatitis to that of healthy oral...

2010-06-24 15:48:36

Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant digestive tumor with a very poor prognosis. Hypoxia-inducible transcription factor-1ÃŽ± (HIF-1ÃŽ±) is involved in malignant progression in many solid tumors, including PDAC, upregulation of HIF-1ÃŽ± accelerates PDAC progression, but the exact regulatory mechanisms of HIF-1ÃŽ±in PDAC has not been unequivocally addressed. Recently, an increasing number of...

2010-06-07 13:52:55

Researchers from Helmholtz-Centre in Braunschweig, Germany, decipher how mast cells set immune defense on the right track In the event of an infection, the immune system releases messenger substances. These molecules can either activate immune cells to defeat invading pathogens, or inhibit them to prevent an excessive immune reaction. For this, the immune system has to decide very quickly what mixture of activating and inhibiting messenger molecules leads to a successful defence. Researchers...

2010-03-05 09:37:48

Today, during the 39th Annual Meeting of the American Association for Dental Research, convening at the Walter E. Washington Convention Center in Washington, DC, lead researcher O.A. Gonzalez (University of Kentucky, Lexington) will present a poster of a study titled "TLR2 and TLR9 Activation by Periodontal Pathogens induce HIV-1 Reactivation." Although oral co-infections (e.g. periodontal disease) are highly prevalent in HIV-1 patients and appear to positively correlate with viral load...


Word of the Day
drawcansir
  • A blustering, bullying fellow; a pot-valiant braggart; a bully.
This word is named for Draw-Can-Sir, a character in George Villiers' 17th century play The Rehearsal.
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