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Latest Toxicogenomics Stories

2013-12-05 23:46:26

Sometimes the cure can be worse than the disease. Pharmaceutical drugs are known for their potential side effects, and an important aspect of personalized medicine is to tailor therapies to individuals to reduce the chances of adverse events. Now researchers from North Carolina State University have updated an extensive toxicology database so that it can be used to track information about therapeutic drugs and their unintentional toxic effects. “Environmental science actually shares a...

2013-04-18 21:33:28

Keeping up with current scientific literature is a daunting task, considering that hundreds to thousands of papers are published each day. Now researchers from North Carolina State University have developed a computer program to help them evaluate and rank scientific articles in their field. The researchers use a text-mining algorithm to prioritize research papers to read and include in their Comparative Toxicogenomics Database (CTD), a public database that manually curates and codes data...

2013-04-18 11:37:41

A new text-mining algorithm can help identify the most relevant scientific research for a public database that reveals the effects of environmental chemicals on human health, according to research published April 17 in the open access journal PLOS ONE by Allan Peter Davis, Thomas Wiegers and colleagues from North Carolina State University. The Comparative Toxicogenomics Database (CTD), managed in part by the lead authors, is a manually curated, public database that correlates environmental...

2012-08-16 00:40:36

Though no systemic studies have been performed, it is generally believed that genes are the most sensitive toxicological endpoints for pollutants, and are thus desirable early warning indicators of environmental risks. A recent study, however, unexpectedly found that the sensitivity of the gene expression effect for cadmium was significantly lower than the individual level chronic toxicity indicators (such as the no observed effect concentration, NOEC). Therefore, the gene expression effect...

2010-12-17 11:30:00

EVREUX, France and WATERTOWN, Mass., Dec. 17, 2010 /PRNewswire/ -- CIT, the preclinical drug safety CRO based outside Paris, and Biomodels, the Boston-based service company offering tailor-made preclinical efficacy models, announce today the signature of an alliance agreement. Under the terms of this transatlantic agreement, the two companies will develop packages of integrated services covering the early development of candidate drugs and their passage into the development phase. The...

2010-08-17 05:00:00

REDWOOD CITY, Calif., Aug. 17 /PRNewswire/ -- Ingenuity® Systems, the leading provider of information solutions for life science researchers, today announced the release of the white paper, "Best Practices for Assessing Toxicity throughout the Drug Discovery Process: Toxicogenomics." The white paper is based on input from industry experts and shows how multidisciplinary toxicology teams in drug discovery can leverage toxicogenomics and IPA® for improved...

2010-07-26 07:00:00

MORRISVILLE, N.C., July 26 /PRNewswire/ -- Gentris Corporation, a global leader in applied clinical pharmacogenomics, announced today that they have appointed Karen Weck, M.D., as a consulting Medical Director. Dr. Weck replaces the previous medical director to continue Gentris' CLIA program and help expand opportunities to develop new biomarkers. "Gentris is very fortunate to have Dr. Weck join us as a consulting Medical Director," said Dawn Bordeaux, Chief Operating Officer of Gentris....

2009-03-17 06:00:00

ST. JOSEPH, Mich., March 17 /PRNewswire/ -- GeneGo, Inc., the leading provider of pathway data mining & analysis solutions, today announced a license agreement with Entelos of Foster City, CA, a company specializing in predictive technologies, including toxicogenomics and PhysioLab(R) virtual human disease models. GeneGo will use Entelos' DrugMatrix(R) gene expression data to further develop GeneGo's Functional Descriptor predictive toxicology models. "Access to a comprehensive,...

2008-07-30 12:00:36

Biomax Informatics and the Mount Desert Island Biological Laboratory have announced that Biomax will integrate MDI's comparative toxicogenomics database into the BioXM knowledge management environment. Mount Desert Island Biological Laboratory's (MDI) comparative toxicogenomics database (CTD) is a valuable, manually curated resource, which advances understanding the effects of environmental chemicals on human health. Biomax will offer CTD as a free content resource to all users of Biomax's...

2008-07-11 12:01:04

Entelos has announced that Eli Lilly and Company has exercised its right to a perpetual license to Entelos's DrugMatrix database and additional customized report services from ToxFx. Entelos's DrugMatrix database is said to be a unique reference set of gene expression profiles for benchmark drugs and compounds that are linked to classic pharmacology, toxicology and clinical pathology measurements. It is populated with the comprehensive results of thousands of highly controlled and...


Word of the Day
lunula
  • A small crescent-shaped structure or marking, especially the white area at the base of a fingernail that resembles a half-moon.
This word is a diminutive of the Latin 'luna,' moon.
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