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2012-04-05 21:16:03

Yale researchers show in detail how three genes within human embryonic stem cells regulate development, a finding that increases understanding of how to grow these cells for therapeutic purposes. This process, described in the April 6 issue of the journal Cell Stem Cell, is different in humans than in mice, highlighting the importance of research using human embryonic stem cells. "It is difficult to deduce from the mouse how these cells work in humans," said Natalia Ivanova, assistant...

2012-03-28 10:23:05

RICHMOND, Calif., March 28, 2012 /PRNewswire/ --Sangamo BioSciences, Inc. (Nasdaq: SGMO) announced today that Edward Lanphier, Sangamo's president and CEO, will provide an update on the progress of Sangamo's ZFP Therapeutic® development programs and an overview of the company's business strategy at 8:40 am ET on Wednesday, April 4, 2012, at the 11th Annual Needham Healthcare Conference which will be held in New York City. The presentation will be webcast live and may be accessed via a...

2012-03-26 22:21:05

Team discovers mechanism for destroying particular cancer cells An international team of scientists has announced a new advance in the ability to target and destroy certain cancer cells. A group led by the University of Leicester has shown that particular cancer cells are especially sensitive to a protein called p21. This protein usually forces normal and cancer cells to stop dividing but it was recently shown that in some cases it can also kill cancer cells. However, scientists have...

2012-03-20 11:19:01

Hedgehog and mTOR converge; Findings suggest new combination therapy Identification of a non-traditional pathway for spiriting a cancer-promoting protein into the cell nucleus points to a possible combination therapy for esophageal cancer and indicates a mechanism of resistance for new drugs that attack the Hedgehog pathway. A team of researchers at The University of Texas MD Anderson Cancer Center reports in the March 20 Cancer Cell that the mTOR molecular pathway promotes the activity...

2012-03-19 16:55:39

Putting the brakes on an abundant growth-promoting protein causes breast tumors to regress, according to a study published on March 19th in the Journal of Experimental Medicine. Triple-negative breast tumors lack all of the known growth receptors that serve as treatment targets in other types of breast cancer, making this the most clinically challenging subtype of the disease. Patients with these tumors tend to relapse earlier and have shorter disease-free survival. Andrei Goga and...

2012-03-19 02:24:53

CARLSBAD, Calif., March 19, 2012 /PRNewswire/ -- Life Technologies Corporation (NASDAQ:LIFE) today announced the launch of GeneArt® Precision TALs, generally referred to as TAL effector proteins (TALE), which will allow researchers the ability to edit genomes and control gene activity with unprecedented precision and reliability. (Photo: http://photos.prnewswire.com/prnh/20120319/LA71858) "We expect the GeneArt® TAL launch to be enthusiastically welcomed by the scientific...

2012-03-14 20:46:55

Researchers at the RIKEN Omics Science Center (OSC) have successfully developed and demonstrated a new experimental technique for producing cells with specific functions through the artificial reconstruction of transcriptional regulatory networks. As an alternative to induced pluripotent stem cells, the technique promises to enable faster and more efficient production of functional cells for use in cancer therapy and a variety of other areas. Starting with the first-ever production of...

2012-03-12 11:18:18

Scientists discover protein and move a step closer to preventing cardiovascular disease Researchers from Queen Mary, University of London and the University of Surrey have found a protein inside blood vessels with an ability to protect the body from substances which cause cardiovascular disease. The findings, published online in the journal Cardiovascular Research, have revealed the protein pregnane X receptor (PXR) can switch on different protective pathways in the blood vessels....

2012-03-08 14:55:37

UCSF Identifies New Target Against Obesity Involving Brown Fat In the war against obesity, one´s own fat cells may seem an unlikely ally, but new research from the University of California, San Francisco (UCSF) suggests ordinary fat cells can be reengineered to burn calories. While investigating how a common drug given to people with diabetes works in mice, a UCSF team discovered that a protein called PRDM16, found in both men and mice, can throw a switch on fat cells, converting...