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Latest Transcription factors Stories

2013-12-20 10:34:33

Reprogramming of liver ‘clock’ may contribute to metabolic disorders A high-fat diet affects the molecular mechanism controlling the internal body clock that regulates metabolic functions in the liver, UC Irvine scientists have found. Disruption of these circadian rhythms may contribute to metabolic distress ailments, such as diabetes, obesity and high blood pressure. There’s good news, though. The researchers also discovered that returning to a balanced, low-fat diet normalized...

2013-12-11 13:21:25

Chinese researchers from Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, BGI and other institutes identified the recurrent T372R mutation in the transcription factor YY1 (Yin Yang 1) are related with insulinoma oncogenesis, implicating a potential marker for the diagnosis and treatment of functional pancreatic neuroendocrine tumors (PNETs). The latest study was published online in Nature Communications. Pancreatic neuroendocrine tumors are classified into functional and...

2013-11-27 15:37:32

Discovery also reveals how a drug, now in multiple human trials, halts production of Myc protein and stops progression of AML A team of researchers at Cold Spring Harbor Laboratory (CSHL) has identified a leukemia-specific stretch of DNA called an enhancer element that enables cancerous blood cells to proliferate in Acute Myeloid Leukemia (AML), a devastating cancer that is incurable in 70% of patients. Just as important, the findings offer a mechanistic insight into how a new class of...

2013-11-25 14:40:21

2 separate studies yield key findings for the prevention, diagnosis, treatment and cure for the disease Acute myeloid leukemia (AML) is a group of heterogeneous diseases with considerable diversity in terms of genetic abnormalities. Mutations of CEBPA, a tumour suppressor, are found in about 10 per cent of human AML patients. In two separate studies on CEBPA mutations in AML subtypes, researchers successfully identified and validated a gene known as Sox4 as a potential therapeutic target...

Genetic Variant Linked To Freckling, Sun Sensitivity Discovered
2013-11-22 08:16:48

[ Watch the Video: Genetic Variant Linked To Freckling And Sun Sensitivity ] April Flowers for redOrbit.com - Your Universe Online A genomic variant strongly associated with sensitivity to the sun, brown hair, blue eyes and freckles has been identified by a new study. Researchers studying Icelanders discovered an intricate pathway involving the interspersed DNA sequence, or non-coding region, of a gene that is among a few dozen that are associated with human pigmentation traits. The...

2013-11-21 13:07:01

Gene found in human speech problems affects singing, not learning in songbirds A genetic defect that profoundly affects speech in humans also disrupts the ability of songbirds to sing effective courtship tunes. This defect in a gene called FoxP2 renders the brain circuitry insensitive to feel-good chemicals that serve as a reward for speaking the correct syllable or hitting the right note, a recent study shows. The research, which was conducted in adult zebrafinches, gives insight into...

2013-11-13 13:27:31

A class of drugs used to treat parasitic infections such as malaria may also be useful in treating cancers and immune-related diseases, a new WSU-led study has found. Researchers discovered that simple modifications to the drug furamidine have a major impact on its ability to affect specific human proteins involved in the on-off switches of certain genes. “This was rather unexpected, given how relatively simple the molecules are that we modified and how difficult it has been to affect...

2013-10-30 15:38:23

A new study by Weill Cornell Medical College scientists reveals a mechanism through which the expression of genes is controlled -- a finding that highlights genetic mutations that can impair the timing of gene expression. Such mutations can affect the co-ordination of key events that are required for stepwise development of an organism, and can also give rise to cancer by turning on genes at the wrong time. The study, published October 29 in the open access journal PLOS Biology, analyzes...

Mechanism Through Which The Expression Of Genes Is Controlled Revealed
2013-10-30 08:58:05

Public Library of Science A new study by Weill Cornell Medical College scientists reveals a mechanism through which the expression of genes is controlled – a finding that highlights genetic mutations that can impair the timing of gene expression. Such mutations can affect the co-ordination of key events that are required for stepwise development of an organism, and can also give rise to cancer by turning on genes at the wrong time. The study, published October 29 in the open access...


Word of the Day
bellycheer
  • Good cheer; viands.
  • To revel; to feast.
The word 'bellycheer' may come from 'belle cheer', "good cheer".
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