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2012-09-20 16:52:24

The androgen receptor in human cells inhibits fat accumulation, but its activity can be sabotaged by glucocorticoids, steroids that regulate fat deposition and are known drivers of obesity and insulin resistance, said researchers led by those at Baylor College of Medicine (www.bcm.edu) in a report in the journal Chemistry & Biology (https://www.cell.com/chemistry-biology/home). "The project started with a straightforward search for genes or signals specific to human fat cells," said...

New Efficiency Brought To Stem Cell Reprogramming
2012-09-13 12:35:17

Biologists reveal genes key to development of pluripotency, in single cells Several years ago, biologists discovered that regular body cells can be reprogrammed into pluripotent stem cells – cells with the ability to become any other type of cell. Such cells hold great promise for treating many human diseases. These induced pluripotent stem cells (iPSCs) are usually created by genetically modifying cells to overexpress four genes that make them revert to an immature, embryonic...

2012-08-30 10:25:17

RICHMOND, Calif., Aug. 30, 2012 /PRNewswire/ -- Sangamo BioSciences, Inc. (Nasdaq: SGMO) announced today that Edward Lanphier, Sangamo's president and CEO, will provide an update on the progress of Sangamo's ZFP Therapeutic(® )development programs and an overview of the company's business strategy at 3:50 pm ET on Thursday, September 6, 2012, at the Stifel Nicolaus Healthcare Conference which will be held in New York City. The presentation will be webcast live and may be accessed via a...

2012-08-29 07:06:26

8-9 percent of human diabetes is type 3c; Olatz Zenarruzabeitia, a biologist at the University of the Basque Country, is analysing a pathway for developing it as well as preventing it in mice Mice develop pancreatic diabetes (type 3c) when they lack certain genes in the E2F group, and to understand how this happens, Olatz Zenarruzabeitia has focussed on the molecular mechanism behind it. This researcher works at the laboratory of Ana Zubiaga, Professor of Genetics of the University of the...

2012-08-28 02:29:42

IRVINE, Calif., Aug. 28, 2012 /PRNewswire/ -- GeneTex, Inc., a leading manufacturer of antibodies, has announced that they will be launching a new antibody against HIF1a (hypoxia-inducible factor 1alpha). (Photo: http://photos.prnewswire.com/prnh/20120828/AQ63427) (Logo: http://photos.prnewswire.com/prnh/20111129/LA13485LOGO-b) Hypoxia, a physiological state characterized by reduced oxygen levels, impacts metabolism, angiogenesis, vasodilation and erythropoiesis through the HIF1a...

2012-08-23 10:34:51

Researchers at the Georgia Health Sciences University Cancer Center have identified a gene that disrupts the inflammatory process implicated in liver cancer. Laboratory mice bred without the gene lacked a pro-inflammatory protein called TREM-1 and protected them from developing liver cancer after exposure to carcinogens. The study, published in Cancer Research, a journal for the American Association for Cancer Research, could lead to drug therapies to target TREM-1, said Dr. Anatolij...

Mole And Shrew Differences Is In Their SOX
2012-08-14 10:08:05

redOrbit Staff & Wire Reports - Your Universe Online Talpidae is a family of small insectivores which includes the moles, shrew moles, and aquatic desmans. New research has found that the large size of the moles' digging front paws, compared to their feet, is controlled by altered timing of expression of the gene SOX9. This research is published in BioMed Central's open access journal EvoDevo. Adaption to burrowing underground has given Fossorial (digging) moles, which are closely...

2012-08-06 22:01:17

Two proteins that act in opposing directions — one that promotes cancer and one that suppresses cancer – regulate the same set of genes in prostate cancer, Vanderbilt-Ingram Cancer Center researchers have found. The findings, reported recently in the Journal of Clinical Investigation, point toward potential drug targets and prognostic markers for prostate cancer. "We are trying to understand the molecular genetics of prostate cancer: what are the genes that are altered in...

2012-08-03 23:02:12

Researchers at Mount Sinai School of Medicine, the University of Manchester, and the MD Anderson Cancer Center have found a new role for an oncogenic signaling pathway in embryonic stem cell (ESC) self-renewal and in reprogramming adult cells into an ESC-state, which will aid in the development of future cancer therapies. New York, NY (PRWEB) August 03, 2012 Researchers at Mount Sinai School of Medicine, the University of Manchester, and the MD Anderson Cancer Center have found a new role...

A New Target For The Treatment Of Diabetes And Obesity
2012-08-02 15:15:52

Researchers at Washington University School of Medicine in St. Louis have identified a potential target for treating diabetes and obesity. Studying mice, they found that when the target protein was disabled, the animals became more sensitive to insulin and were less likely to get fat even when they ate a high-fat diet that caused their littermates to become obese. The findings are published online in the journal Cell Metabolism. The researchers studied how the body manufactures fat...