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Latest Transcription factors Stories

2012-12-13 12:26:27

Researchers at Michigan State University have discovered a protein that does its best work with one foot in the grave. The study, which appears in the current issue of the Journal of Biological Chemistry, focuses on the nontraditional lifestyle of Retinoblastoma tumor suppressor proteins, which could lead to new ways to treat cancer. “Retinoblastoma proteins are unique in that they use controlled destruction to do their jobs in a timely but restrained fashion,” said Liang...

How Fins Became Legs Revealed
2012-12-10 13:52:58

Cell Press Vertebrates' transition to living on land, instead of only in water, represented a major event in the history of life. Now, researchers reporting in the December issue of the Cell Press journal Developmental Cell provide new evidence that the development of hands and feet occurred through the gain of new DNA elements that activate particular genes. "First, and foremost, this finding helps us to understand the power that the modification of gene expression has on shaping our...

2012-12-03 13:50:21

Promising target for the development of novel drugs With the X-ray vision of DESY's light source DORIS, a research team from Hamburg and Iceland has uncovered the molecular structure of a master regulator central to the most deadly form of skin cancer, melanoma. The results, published in the scientific journal "Genes & Development", throw new light on the workings of the so-called Microphthalmia-associated Transcription Factor MITF, that is not only connected to skin cancer, but also...

2012-10-09 22:19:00

Discovery of new biological pathway may help scientists redesign certain diabetes drugs to eliminate or reduce adverse side effects Many drugs work by "fixing" a particular biological pathway that's gone awry in a disease. But sometimes drugs affect other pathways too, producing undesirable side effects that can be severe enough to outweigh the drug's benefits. Such is the case for the thiazolidinedione drugs (also known as TZDs), which are used to treat type 2 diabetes. These are...

Single Device Can Measure Hundreds Of Biomolecular Interactions
2012-09-26 07:42:18

Scientists at EPFL and the University of Geneva have developed a microfluidic device smaller than a domino that can simultaneously measure up to 768 biomolecular interactions. Inside our cells, molecules are constantly binding and separating from one another. It´s this game of constant flux that drives gene expression asides essentially every other biological process. Understanding the specific details of how these interactions take place is thus crucial to our overall...


Word of the Day
cock-a-hoop
  • Exultant; jubilant; triumphant; on the high horse.
  • Tipsy; slightly intoxicated.
This word may come from the phrase 'to set cock on hoop,' or 'to drink festively.' Its origin otherwise is unclear. A theory, according to the Word Detective, is that it's a 'transliteration of the French phrase 'coq a huppe,' meaning a rooster displaying its crest ('huppe') in a pose of proud defiance.' Therefore, 'cock-a-hoop' would 'liken a drunken man to a boastful and aggressive rooster.'
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