Quantcast
Last updated on April 18, 2014 at 21:21 EDT

Latest Transcription factors Stories

A New Target For The Treatment Of Diabetes And Obesity
2012-08-02 15:15:52

Researchers at Washington University School of Medicine in St. Louis have identified a potential target for treating diabetes and obesity. Studying mice, they found that when the target protein was disabled, the animals became more sensitive to insulin and were less likely to get fat even when they ate a high-fat diet that caused their littermates to become obese. The findings are published online in the journal Cell Metabolism. The researchers studied how the body manufactures fat...

2012-07-31 12:27:31

During Alzheimer's disease, 'plaques' of amyloid beta (Ab) and tau protein 'tangles' develop in the brain, leading to the death of brain cells and disruption of chemical signaling between neurons. This leads to loss of memory, mood changes, and difficulties with reasoning. New research published in BioMed Central's open access journal Alzheimer's Research & Therapy, has found that up-regulating the gene Hes1 largely counteracted the effects of Ab on neurons, including preventing cell...

2012-07-25 02:29:07

NATICK, Mass., July 25, 2012 /PRNewswire/ -- Karyopharm Therapeutics Inc., a leader in the new field of nuclear transport modulators, announced dosing of patients in the first-in-human clinical trials with KPT-330. KPT-330 is the first oral SINE CRM1 antagonist to enter human studies. SINEs specifically and irreversibly inhibit the nuclear export protein CRM1 (chromosome region maintenance protein 1), also called exportin 1 (XPO1). CRM1 is the exclusive mediator of nuclear export of p53,...

2012-07-18 10:26:34

RICHMOND, Calif., July 18, 2012 /PRNewswire/ -- Sangamo BioSciences, Inc. (Nasdaq: SGMO) today announced that the company will release its second quarter 2012 financial results on Wednesday, July 25, 2012, after the market closes. The press release will be followed by a conference call at 5:00 p.m. ET, which will be open to the public via telephone and webcast. During the conference call, the company will review the financial results and discuss other business matters. The conference call...

2012-07-13 10:38:25

An important breakthrough by IRCM researchers contributes to a better understanding of the human genome Researchers at the IRCM, led by geneticist Dr. Jacques Drouin, recently defined the interaction between two essential proteins that control inflammation. This important breakthrough will be published in tomorrow's print edition of the scientific journal Molecular Cell. IRCM scientists study glucocorticoids, a class of steroid hormones that suppress the immune system and reduce...

2012-07-03 10:23:03

RICHMOND, Calif., July 3, 2012 /PRNewswire/ -- Sangamo BioSciences, Inc. (Nasdaq: SGMO) announced today that Edward Lanphier, Sangamo's president and CEO, will provide an update on the progress of Sangamo's ZFP Therapeutic® development programs and an overview of the company's business strategy at 10:00 am ET on Thursday, July 12, 2012, at the Seventh Annual JMP Securities Healthcare Conference which will be held in New York City. The presentation will be webcast live and may be accessed...

2012-07-02 23:11:52

Preclinical imaging of progesterone receptor signals usefulness of biomarker in determining effectiveness of therapy Research published in the July issue of The Journal of Nuclear Medicine shows imaging progesterone receptor (PR) status also may be able to identify responders and nonresponders to endocrine therapy at an early stage. Estrogen receptor-α(ERα) status is an important factor in determining the most appropriate treatment for breast cancer patients,...

2012-06-19 11:23:40

In Huntington's disease, abnormally long strands of glutamine in the huntingtin (Htt) protein, called polyglutamines, cause subtle changes in cellular functions that lead to neurodegeneration and death. Studies have shown that the activation of the heat shock response, a cellular reaction to stress, doesn't work properly in Huntington's disease. In their research to understand the effects of mutant Htt on the master regulator of the heat shock response, HSF1, researchers have discovered that...

2012-06-07 09:14:54

Research suggests selection shapes evolution of aggression via changes in sex steroid molecules An Indiana University biologist has shown that natural variation in measures of the brain's ability to process steroid hormones predicts functional variation in aggressive behavior. The new work led by Kimberly A. Rosvall, a postdoctoral fellow and assistant research scientist in the IU Bloomington College of Arts and Sciences' Department of Biology, has found strong and significant...

2012-06-04 17:21:14

Some neurological conditions such as multiple sclerosis and cerebral palsy are associated with the inability to repair the chronic destruction of myelin sheaths that surround the core of a nerve fiber and function to speed transmission of nerve impulses. To better understand the failure to remyelinate these nerves in disorders involving loss of these sheaths, researchers at Baylor College of Medicine examined how myelin forms during development. They found that a transcription factor known...