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Latest Transcription factors Stories

2012-12-03 13:50:21

Promising target for the development of novel drugs With the X-ray vision of DESY's light source DORIS, a research team from Hamburg and Iceland has uncovered the molecular structure of a master regulator central to the most deadly form of skin cancer, melanoma. The results, published in the scientific journal "Genes & Development", throw new light on the workings of the so-called Microphthalmia-associated Transcription Factor MITF, that is not only connected to skin cancer, but also...

2012-10-09 22:19:00

Discovery of new biological pathway may help scientists redesign certain diabetes drugs to eliminate or reduce adverse side effects Many drugs work by "fixing" a particular biological pathway that's gone awry in a disease. But sometimes drugs affect other pathways too, producing undesirable side effects that can be severe enough to outweigh the drug's benefits. Such is the case for the thiazolidinedione drugs (also known as TZDs), which are used to treat type 2 diabetes. These are...

Single Device Can Measure Hundreds Of Biomolecular Interactions
2012-09-26 07:42:18

Scientists at EPFL and the University of Geneva have developed a microfluidic device smaller than a domino that can simultaneously measure up to 768 biomolecular interactions. Inside our cells, molecules are constantly binding and separating from one another. It´s this game of constant flux that drives gene expression asides essentially every other biological process. Understanding the specific details of how these interactions take place is thus crucial to our overall...

2012-09-20 16:52:24

The androgen receptor in human cells inhibits fat accumulation, but its activity can be sabotaged by glucocorticoids, steroids that regulate fat deposition and are known drivers of obesity and insulin resistance, said researchers led by those at Baylor College of Medicine (www.bcm.edu) in a report in the journal Chemistry & Biology (https://www.cell.com/chemistry-biology/home). "The project started with a straightforward search for genes or signals specific to human fat cells," said...

New Efficiency Brought To Stem Cell Reprogramming
2012-09-13 12:35:17

Biologists reveal genes key to development of pluripotency, in single cells Several years ago, biologists discovered that regular body cells can be reprogrammed into pluripotent stem cells – cells with the ability to become any other type of cell. Such cells hold great promise for treating many human diseases. These induced pluripotent stem cells (iPSCs) are usually created by genetically modifying cells to overexpress four genes that make them revert to an immature, embryonic...

2012-08-29 07:06:26

8-9 percent of human diabetes is type 3c; Olatz Zenarruzabeitia, a biologist at the University of the Basque Country, is analysing a pathway for developing it as well as preventing it in mice Mice develop pancreatic diabetes (type 3c) when they lack certain genes in the E2F group, and to understand how this happens, Olatz Zenarruzabeitia has focussed on the molecular mechanism behind it. This researcher works at the laboratory of Ana Zubiaga, Professor of Genetics of the University of the...


Word of the Day
ambsace
  • Bad luck; misfortune.
  • The smallest amount possible or the most worthless thing.
The word 'ambsace' comes from a Latin word meaning 'both'.