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Latest Transcription factors Stories

2012-05-29 10:23:33

?KALAMAZOO, Mich., May 29, 2012 /PRNewswire/ -- A study published online in the Journal of Biological Chemistry (http://www.jbc.org/content/early/2012/05/23/jbc.M112.363960) showed a new drug to treat diabetes being developed by Metabolic Solutions Development Company, LLC (MSDC), MSDC-0602, improved insulin resistance and inflammation in obese mice. These findings by researchers at Washington University School of Medicine, in collaboration with colleagues at the University of Michigan and...

2012-05-11 15:09:28

New research findings show that embryonic stem cells unable to fully compact the DNA inside them cannot complete their primary task: differentiation into specific cell types that give rise to the various types of tissues and structures in the body. Researchers from the Georgia Institute of Technology and Emory University found that chromatin compaction is required for proper embryonic stem cell differentiation to occur. Chromatin, which is composed of histone proteins and DNA, packages DNA...

2012-05-07 13:37:07

New research in the FASEB Journal suggests that Rev-Erb alpha, a known component of the body clock, plays the role of a molecular integrator which ensures proper timing in fuel use and energy homeostasis If you're counting calories to lose weight, that may be only part of the weight loss equation says a new research report published online in The FASEB Journal (http://www.fasebj.org). In the report, French scientists show that impairments to a gene known to be responsible for our internal...

2012-05-03 15:09:07

Presentations at the 4th IMPAKT Breast Cancer Conference American and Spanish researchers have found potential ways for doctors to improve the treatment of hormone receptor-positive breast cancer even if they lack access to costly multi-gene tests, as they report at the 4th IMPAKT Breast Cancer Conference. Because breast cancer is a biologically and clinically varied disease, doctors aim to choose appropriate treatments based on the characteristics of each patient's individual tumor. In...

2012-05-02 15:09:41

In the United States, a baby is born with a facial cleft every hour, of every day of the year! Such birth defects result from both gene mutations and environmental insults. PRDM16 is a transcription factor originally described as being aberrantly activated in specific types of leukemia's, and more recently as a master regulator of brown adipose tissue differentiation. In a study published in the April 2012 issue of Experimental Biology and Medicine, investigators have now shown that this...

2012-04-27 00:05:50

Researchers at The Wistar Institute announce the discovery of small molecules that kill cancer cells caused by infection with human papillomavirus (HPV).  Their results, in both cell and mouse models, demonstrate that the small molecule inhibitors protect a tumor-suppressing protein targeted by viral proteins, thus killing the infected tumor cells. The Wistar scientists presented their findings in the April 20 issue of the journal Chemistry & Biology.  The researchers believe...

2012-04-26 23:54:58

Researchers trace influence via mouse model that allows oncogene to be turned on and off A genetic mutation that drives the initiation of pancreatic cancer also manipulates metabolic pathways to support tumor growth and progression, scientists report in the journal Cell. This newly discovered role for the Kras oncogene opens up a new category of potential targets for thwarting the influential mutation, which has proved difficult to attack directly, said study co-lead author Haoqiang...

2012-04-25 10:25:13

RICHMOND, Calif., April 25, 2012 /PRNewswire/ -- Sangamo BioSciences, Inc. (Nasdaq: SGMO) today announced that the company will release its first quarter 2012 financial results on Wednesday, May 2, 2012, after the market closes. The press release will be followed by a conference call at 5:00 p.m. ET, which will be open to the public via telephone and webcast. During the conference call, the company will review the financial results and discuss other business matters. The conference call...

2012-04-12 14:22:01

RICHMOND, Calif., April 12, 2012 /PRNewswire/ -- Sangamo BioSciences, Inc. (Nasdaq: SGMO) announced today that Edward Lanphier, Sangamo's president and CEO, will provide an update on the progress of Sangamo's ZFP Therapeutic® development programs and an overview of the company's business strategy at 1:30 pm ET on Friday, April 20, 2012, at the Future Leaders in the Biotech Industry Conference which will be held in New York City. The presentation will be webcast live and may be accessed...

2012-04-11 22:30:42

Anyone who's tried a weekend home improvement project knows that to do a job right, you've got to have the right tools. For cells, these "tools" are proteins encoded by genes. The right genes for the job are turned on only in the specific cells where they are needed. And every cell in your body has a specific job to do. Cells in your pancreas have to produce insulin, while cells in the retina of your eye must be able to sense light and color. Like using the wrong tool for the job, if the...