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Latest Transcription factors Stories

2012-07-31 12:27:31

During Alzheimer's disease, 'plaques' of amyloid beta (Ab) and tau protein 'tangles' develop in the brain, leading to the death of brain cells and disruption of chemical signaling between neurons. This leads to loss of memory, mood changes, and difficulties with reasoning. New research published in BioMed Central's open access journal Alzheimer's Research & Therapy, has found that up-regulating the gene Hes1 largely counteracted the effects of Ab on neurons, including preventing cell...

2012-07-13 10:38:25

An important breakthrough by IRCM researchers contributes to a better understanding of the human genome Researchers at the IRCM, led by geneticist Dr. Jacques Drouin, recently defined the interaction between two essential proteins that control inflammation. This important breakthrough will be published in tomorrow's print edition of the scientific journal Molecular Cell. IRCM scientists study glucocorticoids, a class of steroid hormones that suppress the immune system and reduce...

2012-07-02 23:11:52

Preclinical imaging of progesterone receptor signals usefulness of biomarker in determining effectiveness of therapy Research published in the July issue of The Journal of Nuclear Medicine shows imaging progesterone receptor (PR) status also may be able to identify responders and nonresponders to endocrine therapy at an early stage. Estrogen receptor-α(ERα) status is an important factor in determining the most appropriate treatment for breast cancer patients,...

2012-06-19 11:23:40

In Huntington's disease, abnormally long strands of glutamine in the huntingtin (Htt) protein, called polyglutamines, cause subtle changes in cellular functions that lead to neurodegeneration and death. Studies have shown that the activation of the heat shock response, a cellular reaction to stress, doesn't work properly in Huntington's disease. In their research to understand the effects of mutant Htt on the master regulator of the heat shock response, HSF1, researchers have discovered that...

2012-06-07 09:14:54

Research suggests selection shapes evolution of aggression via changes in sex steroid molecules An Indiana University biologist has shown that natural variation in measures of the brain's ability to process steroid hormones predicts functional variation in aggressive behavior. The new work led by Kimberly A. Rosvall, a postdoctoral fellow and assistant research scientist in the IU Bloomington College of Arts and Sciences' Department of Biology, has found strong and significant...

2012-06-04 17:21:14

Some neurological conditions such as multiple sclerosis and cerebral palsy are associated with the inability to repair the chronic destruction of myelin sheaths that surround the core of a nerve fiber and function to speed transmission of nerve impulses. To better understand the failure to remyelinate these nerves in disorders involving loss of these sheaths, researchers at Baylor College of Medicine examined how myelin forms during development. They found that a transcription factor known...


Word of the Day
pungle
  • To take pains; labor assiduously with little progress.
This word comes from the Spanish 'pongale,' put it.
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