Latest Transforming growth factor Stories
Notch – the protein that can help determine cell fate – maintains a stable population of basal cells in the prostate through a positive feedback loop system with another key protein – TGF beta (transforming growth factor beta), said Baylor College of Medicine researchers in the journal Cell Stem Cell.
A USC research team has pinpointed the source of a genetic disorder that causes life-threatening birth defects, which may allow doctors to quickly diagnose and better treat the disease.
Glioblastoma is regarded as the most malignant form of brain tumor.
Scientists at Johns Hopkins have shown in laboratory experiments in mice that blocking the action of a signaling protein deep inside the heart's muscle cells blunts the most serious ill effects of high blood pressure on the heart.
Several years ago, Dr. Arthur Beaudet, Baylor College of Medicine's chair of molecular and human genetics, was surprised to find that mice that lacked a protein called E-selectin ligand-1 were shorter than normal.
By examining tissue removed during breast reduction surgery in healthy women, researchers at Georgetown Lombardi Comprehensive Center have found a molecule they say identified women who had atypical hyperplasia, a potentially precancerous condition in which cells are abnormally increased.
Reporting in Nature Cell Biology, researchers describe the discovery of a specific protein called disabled-2 (Dab2) that switches on the process that releases cancer cells from the original tumor and allows the cells to spread and develop into new tumors in other parts of the body.
UT Southwestern Medical Center researchers have found that a naturally occurring protein â€” transforming growth factor beta1 (TGF-ÃŸ1) â€” which normally suppresses the growth of cancer cells, causes a rebound effect after a prolonged exposure.
Vanderbilt-Ingram Cancer Center researchers have uncovered a gene signature that may help predict clinical outcomes in certain types of breast cancer.
By Ishihara, Hideyuki Kubota, Hisashi; Lindberg, Raija L P; Leppert, David; Gloor, Sergio M; Errede, Mariella; Virgintino, Daniela; Fontana, Adriano; Yonekawa, Yasuhiro; Frei, Karl Abstract Gliomas, particularly glioblastoma multiforme, perturb the blood-brain barrier and cause brain edema that contributes to morbidity and mortality.
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