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Latest Transforming growth factor Stories

2012-11-01 23:13:59

Notch — the protein that can help determine cell fate — maintains a stable population of basal cells in the prostate through a positive feedback loop system with another key protein — TGF beta (transforming growth factor beta), said Baylor College of Medicine researchers in the journal Cell Stem Cell. "When basal cell homeostasis (or maintenance of a stable population) is disrupted, it may be part of the process that initiates prostate cancer," said Dr. Li Xin, assistant...

2012-02-13 23:35:19

Findings from researchers at the Ostrow School of Dentistry at USC may help doctors save lives through rapid diagnosis A USC research team has pinpointed the source of a genetic disorder that causes life-threatening birth defects, which may allow doctors to quickly diagnose and better treat the disease. Babies born with the disorder, known as Loeys-Dietz syndrome or Marfan syndrome type II, have cleft palates and other facial characteristics similar to babies born with other diseases...

2011-11-23 14:21:24

Glioblastoma is regarded as the most malignant form of brain tumor. In many cases, neurosurgeons are not able to remove such tumors completely because of the risk of destroying too much brain tissue in the process. Moreover, it is often impossible to identify all the fine extensions by which the tumor spreads into surrounding healthy tissue. To at least slow down the growth of tumor cells that have remained in the head, almost all glioblastoma patients are treated by radiotherapy after...

2011-05-02 20:47:36

Scientists at Johns Hopkins have shown in laboratory experiments in mice that blocking the action of a signaling protein deep inside the heart's muscle cells blunts the most serious ill effects of high blood pressure on the heart. These include heart muscle enlargement, scar tissue formation and loss of blood vessel growth. Specifically, the Johns Hopkins team found that their intervention halted transforming growth factor beta (TGF-beta) secretion at a precise location called cell receptor...

2010-06-10 15:28:14

Several years ago, Dr. Arthur Beaudet, Baylor College of Medicine's chair of molecular and human genetics, was surprised to find that mice that lacked a protein called E-selectin ligand-1 were shorter than normal. He and his colleagues were hoping that the protein was involved in cell adherence, but instead their mice had a form of dwarfism. They turned the mice and their data over to Dr. Brendan Lee, a professor of molecular and human genetics at BCM, and an expert in the development of...

2010-04-20 14:22:50

By examining tissue removed during breast reduction surgery in healthy women, researchers at Georgetown Lombardi Comprehensive Center have found a molecule they say identified women who had atypical hyperplasia, a potentially precancerous condition in which cells are abnormally increased. Their findings, presented at the AACR 101st Annual Meeting 2010, suggest that this protein, transforming growth factor beta 1 (TGF-ÃŽ²1), could be part of a panel of genes and proteins that...

2010-02-15 07:56:39

Reporting in Nature Cell Biology, researchers describe the discovery of a specific protein called disabled-2 (Dab2) that switches on the process that releases cancer cells from the original tumor and allows the cells to spread and develop into new tumors in other parts of the body. The process called epithelial-mesenchymal transdifferientiation (EMT) has been known to play a role in releasing cells (epithelial cells) on the surface of the solid tumor and transforming them into transient...

2009-12-02 11:24:48

UT Southwestern Medical Center researchers have found that a naturally occurring protein "” transforming growth factor beta1 (TGF-ß1) "” which normally suppresses the growth of cancer cells, causes a rebound effect after a prolonged exposure. Cancer cells go into overdrive and become even more aggressive and likely to spread, the researchers report. The mechanism for this reversal is unknown, but UT Southwestern researchers and their colleagues in...

2009-05-19 14:20:17

Vanderbilt-Ingram Cancer Center researchers have uncovered a gene signature that may help predict clinical outcomes in certain types of breast cancer. In the Journal of Clinical Investigation, Harold (Hal) Moses, M.D., and colleagues report that this gene signature "“ which is associated with the transforming growth factor-beta (TGF-ÃŽ²) signaling pathway "“ correlates with reduced relapse-free survival in patients with breast cancer, especially in those with...

2008-07-01 03:00:12

By Ishihara, Hideyuki Kubota, Hisashi; Lindberg, Raija L P; Leppert, David; Gloor, Sergio M; Errede, Mariella; Virgintino, Daniela; Fontana, Adriano; Yonekawa, Yasuhiro; Frei, Karl Abstract Gliomas, particularly glioblastoma multiforme, perturb the blood-brain barrier and cause brain edema that contributes to morbidity and mortality. The mechanisms underlying this vasogenic edema are poorly understood. We examined the effects of cocultured primary cultured human glioblastoma cells and...


Word of the Day
cruet
  • A vial or small glass bottle, especially one for holding vinegar, oil, etc.; a caster for liquids.
This word is Middle English in origin, and ultimately comes from the Old French, diminutive of 'crue,' flask.
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