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Latest Transmissible spongiform encephalopathies Stories

2010-01-28 15:03:04

Scientists have determined how a normal protein can be converted into a prion, an infectious agent that causes fatal brain diseases in humans and mammals. The finding, in mice, is expected to advance the understanding of transmissible spongiform encephalopathies, or TSEs, a family of neurodegenerative diseases that include Creutzfeldt-Jakob Disease, kuru and fatal familial insomnia in humans, scrapie in sheep, and bovine spongiform encephalopathy in cattle, also known as "mad cow disease."...

2010-01-01 10:42:26

Research may point to more effective therapeutic targets for deadly prion diseases Scientists from The Scripps Research Institute have determined for the first time that prions, bits of infectious protein devoid of DNA or RNA that can cause fatal neurodegenerative disease, are capable of Darwinian evolution. The study from Scripps Florida in Jupiter shows that prions can develop large numbers of mutations at the protein level and, through natural selection, these mutations can eventually...

2009-11-20 12:20:24

A new treatment route for bovine spongiform encephalopathy (BSE) and its human form Creutzfeldt Jakob disease (CJD) could be a step closer based on new results from scientists at the University of Leeds. The team has found that a protein called Glypican-1 plays a key role in the development of BSE. Details are published November 20 in the open-access journal PLoS Pathogens. BSE, commonly known as mad cow disease, is known to be caused by an infectious and abnormal form of the prion protein...

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2009-11-19 11:35:00

Researchers said on Wednesday that villagers in the highlands of Papua New Guinea who ritualistically ate human brains but did not die of a brain disease called kuru have a genetic mutation that protects them, Reuters reported. The study, reported in the New England Journal of Medicine, said the unusual cannibalistic practice shows evolution in real time in the human population, and might lead to a treatment for similar brain-wasting conditions. Entire generations of women in remote Papuan...

2009-11-18 13:51:04

May Promote Prion-Dependent Diseases The regulating protein Srebp2 drives cholesterol formation, which prions need for their propagation, in prion-infected neuronal cells. With these findings, published in the current issue of the Journal of Biological Chemistry, scientists of Helmholtz Zentrum Mnchen and Technische Universität Mnchen anticipate new approaches in drug development to combat prion infection. Prions are causing fatal and infectious diseases of the nervous system, such as...

2009-10-14 13:17:08

Specific cells within the immune system could help explain why younger people are more susceptible to variant CJD, scientists believe Specific cells within the immune system could help explain why younger people are more susceptible to variant CJD, scientists believe. Patients diagnosed with variant CJD are, on average, 28 years old but it has been unclear why older people are not as affected by the disease. Research at The Roslin Institute of the University of Edinburgh has identified...

2009-10-06 07:50:42

A collaboration between scientists at Vanderbilt University and the University of California, San Francisco has led to the first direct information about the molecular structure of prions. In addition, the study has revealed surprisingly large structural differences between natural prions and the closest synthetic analogs that scientists have created in the lab. Prions are the infectious proteins responsible for human Creutzfeldt-Jakob disease, bovine spongiform encephalopathy, or "mad cow"...

2009-09-29 13:14:42

A University of Toronto-led team of scientists says it has determined the evolutionary origin of the prion gene. The researchers said the diseased prion proteins are responsible for the fatal neurodegenerative Creutzfeldt-Jakob disease in humans, bovine spongiform encephalopathy, also known as mad cow disease, as well as scrapie and chronic wasting disease in livestock. The scientists said their findings hold promise for efforts to reveal the physiological function of members of the prion...

2009-09-28 15:31:24

A University of Toronto-led team has uncovered the evolutionary ancestry of the prion gene, which may reveal new understandings of how the prion protein causes diseases such as bovine spongiform encephalopathy (BSE), also known as "mad cow disease." Diseased prion proteins are responsible for the fatal neurodegenerative Creutzfeldt-Jakob disease (CJD) in humans, and BSE, scrapie and chronic wasting disease (CWD) in livestock. Overall, this work holds promise for efforts to reveal the...

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2009-09-10 07:38:02

According to a study published on Wednesday, it appears that a variety of prion disease found in deer may be spread through the fecal matter of infected animals even when they exhibit no symptoms of the illness.  Researchers say that their finds on the deadly brain disorder known as chronic wasting disease (CWD)"”a close cousin of the infamous mad-cow disease"”may have significant ramifications for farmers. The research was led by Nobel laureate Stanley Prusiner at the...


Word of the Day
cruet
  • A vial or small glass bottle, especially one for holding vinegar, oil, etc.; a caster for liquids.
This word is Middle English in origin, and ultimately comes from the Old French, diminutive of 'crue,' flask.
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