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Latest Transmissible spongiform encephalopathies Stories

2011-03-21 13:05:56

Romping clumps of misfolded proteins are prime suspects in many neurological disorders including Alzheimer's, Parkinson's, and Creutzfeld-Jakob Disease. Those diseases are devastating and incurable, but a team of biologists at Brown University reports that cells can fix the problems themselves with only a little bit of help. The insight suggests that there are more opportunities to develop a therapy for protein misfolding than scientists had thought. "There are multiple steps that you could...

2011-03-10 13:48:17

Neena Singh, MD, PhD and colleagues at Case Western Reserve University School of Medicine have identified the first disease-specific biomarker for sporadic Creutzfeldt-Jakob disease (sCJD), a universally fatal, degenerative brain disease for which there is no cure. sCJD is one of the causes of dementia and typically leads to death within a year of disease onset. The finding, published in the March 9th issue of PLoS ONE, a scientific journal produced by the Public Library of Science, provides...

2011-02-23 17:04:27

Scientists who examined more than 10,000 chemical compounds during the last year in search of potential new drugs for a group of untreatable brain diseases, are reporting that one substance shows unusual promise. The early positive signs for so-called prion diseases come from research in laboratory mice and cell cultures, they say in a report in ACS' Journal of Medicinal Chemistry. Adam Renslo and colleagues, who include Nobel Laureate Stanley B. Prusiner, explain that prion diseases include...

2011-02-18 17:21:04

One bad apple is all it takes to spoil the barrel. And one misfolded protein may be all that's necessary to corrupt other proteins, forming large aggregations linked to several incurable neurodegenerative diseases such as Huntington's, Parkinson's and Alzheimer's. Stanford biology Professor Ron Kopito has shown that the mutant, misfolded protein responsible for Huntington's disease can move from cell to cell, recruiting normal proteins and forming aggregations in each cell it visits. Knowing...

2011-02-17 21:07:19

Researchers at the University of California, San Diego School of Medicine have identified the motors that move non-infectious prion proteins (PrPC) "“ found within many mammalian cells "“ up and down long, neuronal transport pathways. Identifying normal movement mechanisms of PrPC may help researchers understand the spread of infectious prions within and between neurons to reach the brain, and aid in development of therapies to halt the transport. Their study is published in the...

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2011-02-03 08:55:00

Researchers have developed what is being called "the world's first accurate blood test" for the human form of mad cow disease, and their discovery could change the way the illness is screened for and diagnosed, the UK-based Medical Research Council (MRC) announced Thursday. According to an MRC press release, the prototype test proved 100,000 times more sensitive than any previous method used to detect variant Creutzfeldt-Jakob disease (vCJD)--a potentially fatal disease that attacks the brain...

2011-01-14 08:51:46

Airborne prions are also infectious and can induce mad cow disease or Creutzfeldt-Jakob disorder. This is the surprising conclusion of researchers at the University of Zurich, the University Hospital Zurich and the University of Tbingen. They recommend precautionary measures for scientific labs, slaughterhouses and animal feed plants. The prion is the infectious agent that caused the epidemic of mad cow disease, also termed bovine spongiform encephalopathy (BSE), and claimed the life of over...

2011-01-14 08:50:08

Scientists at the University of Zurich (Switzerland) and the Federal Research Institute for Animal Health (FLI; Tuebingen) have challenged the notion that airborne prions are innocuous. Details of how inhalation of prion-tainted aerosols induced disease are published January 13 in the open-access journal PLoS Pathogens. It is known that prions can be transmitted through contaminated surgical instruments and, more rarely, through blood transfusions. However, prions are not generally considered...

2011-01-05 07:33:00

HARRISBURG, Pa., Jan. 5, 2011 /PRNewswire-USNewswire/ -- Samples taken from the 41 hunter-killed elk during the state's 2010 hunting season have all tested negative for chronic wasting disease (CWD) and tuberculosis, according to Dr. Walt Cottrell, the Pennsylvania Game Commission's wildlife veterinarian. Cottrell noted that sample collection was greatly facilitated by the tremendous cooperation of the elk hunters and taxidermists. He added that the Game Commission still is awaiting the...

2010-12-17 16:15:21

Findings Point to Normal Prion Protein as Most Effective Therapeutic Target for "Mad Cow" and Related Diseases Scientists from the Florida campus of The Scripps Research Institute have shown that prions, bits of infectious protein that can cause fatal neurodegenerative disease such as bovine spongiform encephalopathy (BSE) or "mad cow disease," have the ability to adapt to survive in a new host environment. In this regard, although they lack DNA and RNA, they behave much like viruses,...


Word of the Day
snash
  • To talk saucily.
  • Insolent, opprobrious language; impertinent abuse.
This word is Scots in origin and probably imitative.