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Latest Transplant rejection Stories

2011-07-18 16:24:01

Avoiding HLA-DR mismatching appears to be beneficial in pediatric kidney transplant patients, however the likelihood of finding a matching donor must be considered against the wait time for a possible donation, according to a report in the July issue of Archives of Surgery, one of the JAMA/Archives journals. "Although avoiding HLA [human leukocyte antigen; cell surface antigens that regulate host cell responses to transplanted cells] antigen mismatching has been shown to benefit long-term...

2011-07-08 00:19:00

EAST HANOVER, N.J., July 8, 2011 /PRNewswire/ -- Novartis Pharmaceuticals Corporation ("Novartis") announced today Phase III trial results that showed more than one-third of patients taking Afinitor® (everolimus) tablets* experienced a 50% or greater reduction in the size of their subependymal giant cell astrocytomas (SEGAs), non-cancerous brain tumors associated with tuberous sclerosis complex (TSC)(1,2,6). This study, the largest prospective clinical trial to date...

2011-06-30 18:20:22

New research published in the Journal of Leukocyte Biology suggests that overexpressing the human programmed death ligand-1 molecule in pig artery endothelial cells induces human immune tolerance A sizzling genetic discovery by Chinese scientists may one day allow pig tissue to be transplanted successfully into humans. Their research presented in the Journal of Leukocyte Biology (http://www.jleukbio.org) represents a major step forward toward filling the shortage of vital organs for human...

2011-06-15 16:13:00

SILVER SPRING, Md., June 15, 2011 /PRNewswire-USNewswire/ --The U.S. Food and Drug Administration today approved Nulojix (belatacept) to prevent acute rejection in adult patients who have had a kidney transplant. The drug is approved for use with other immunosuppressants (medications that suppress the immune system) -- specifically basiliximab, mycophenolate mofetil, and corticosteroids. (Logo: http://photos.prnewswire.com/prnh/20090824/FDALOGO) Nulojix is a type of drug called a...

2011-05-20 07:27:19

(Ivanhoe Newswire)"”Cells found naturally in the body may help prevent the rejection of an organ transplant. Research shows new cell therapy could also eliminate a transplant patient's need for life-long medication and could help their transplant last longer. Currently patients have to take immunosuppressant drugs to prevent a new organ from being rejected after transplant. Unfortunately, these drugs also suppress the immune system leaving the patient more susceptible to tumors and...

2011-05-19 13:53:41

In the first head-to-head comparison of the three most common drugs used at the time of a kidney transplant to prevent organ rejection, researchers found that the least expensive drug "“ at one-half to one-fifth the price "“ is as safe and effective as the other two, according to a paper published by University of Alabama at Birmingham researchers in the May 19, 2011, issue of the New England Journal of Medicine. Based at UAB, researchers in the INTAC trial spent three years...

2011-05-18 16:46:46

New technique will give patients a better chance of having a successful bone marrow or organ transplant University of Minnesota Medical School researchers have discovered a method to quickly and exponentially grow regulatory T-cells "“ also known as "suppressor cells." The new process enables replication of the cells by tens of millions in several weeks, a dramatic increase over previous duplication methods. Historically, regulatory T-cells have been difficult to replicate. The new...

2011-05-18 16:39:05

New cell therapy to prevent organ rejection could remove the need for life-long medication and boost the longevity of a transplant for patients Researchers at King's College London have used cells found naturally in the body, to re-educate the immune system to prevent rejection of an organ transplant while remaining capable of fighting infections and cancer. Currently, patients must take immunosuppressant drugs to prevent a new organ from being rejected after transplantation. However, these...

2011-05-04 07:00:00

DURHAM, N.C., May 4, 2011 /PRNewswire/ -- Argos Therapeutics today announced that its immunotherapy platform based on recombinant human soluble CD83 demonstrated significant promise for renal and heart transplantation. Two studies were presented at the 2011 American Transplant Congress meeting in Philadelphia. The first presentation, titled "Enrichment of Regulatory T Cells by Soluble CD83 Associated with Induction of Kidney Allograft Tolerance," detailed the indirect mechanism by...

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2011-04-17 07:29:20

Studies of the small sea squirt may ultimately help solve the problem of rejection of organ and bone marrow transplants in humans, according to scientists at UC Santa Barbara. An average of 20 registered patients die every day waiting for transplants, due to the shortage of matching donor organs. More than 110,000 people are currently waiting for organ transplants in the U.S. alone. Currently, only one in 20,000 donors are a match for a patient waiting for a transplant. These grim statistics...


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