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Last updated on April 18, 2014 at 8:37 EDT

Latest Tranzyme Pharma Stories

2008-10-16 06:00:10

Tranzyme Pharma, a biopharmaceutical company engaged in the discovery and clinical development of first-in-class small molecule therapeutics, announced that Dr. Helmut Thomas, Senior Vice President of Research and Preclinical Development will present results of a significant proof-of-concept study in cancer cachexia with its novel ghrelin agonist, TZP-101. The presentation will take place at the 20th EORTC-NCI-AACR Symposium on "Molecular Targets and Cancer Therapeutics" in Geneva,...

2008-10-01 06:00:29

Tranzyme Pharma today announced positive Phase IIb results for its first-in-class, highly potent and selective ghrelin agonist, TZP-101, for the management of postoperative ileus (POI). Results demonstrated that TZP-101 was both safe and highly effective in reducing the duration of ileus following surgery in patients undergoing open bowel resection. Over 200 patients were enrolled in an adaptive, multinational, double-blind, placebo-controlled Phase IIb clinical trial designed to assess...

2008-07-22 06:00:17

Tranzyme Pharma, a leading biopharmaceutical company developing novel mechanism-based therapeutics for the treatment of gastrointestinal (GI) and metabolic disorders, announced today that the Company has received Notices of Allowance from the U.S. Patent and Trademark Office (USPTO) for two patent applications entitled "Macrocyclic Modulators of the Ghrelin Receptor" and "Spatially-Defined Macrocyclic Compounds Useful for Drug Discovery". Together, the patents expected to be issued based...

2008-06-25 06:03:22

Tranzyme Pharma has reported positive results from a 'thorough QT/QTc' study of its lead product TZP-101, an intravenous gastrointestinal prokinetic agent currently in two Phase IIb trials for the treatment of postoperative ileus and severe gastroparesis. The study, required by the FDA for all new chemical entities, was conducted to evaluate the cardiac safety of TZP-101, with a focus on cardiac repolarization as measured by the duration of the QT interval in serial electrocardiograms...

2008-06-23 06:00:06

Tranzyme Pharma announces the successful results from a "Thorough QT/QTc" study of the company's lead product TZP-101, an intravenous gastrointestinal prokinetic agent currently in two Phase IIb trials for the treatment of postoperative ileus (POI) and severe gastroparesis. The study, required by the US Food and Drug Administration (FDA) for all new chemical entities, was conducted to evaluate the cardiac safety of TZP-101, with a focus on cardiac repolarization as measured by the...

2008-06-17 06:00:07

Tranzyme Pharma announced today the successful completion of a Phase I, placebo-controlled, single ascending dose study of its orally administered ghrelin agonist, TZP-102. TZP-102 is the second drug candidate from Tranzyme's internal R&D efforts to reach clinical development. It is a potent prokinetic agent initially being developed for the treatment of mild-to-moderate gastroparesis. The Phase I study showed that TZP-102 has excellent oral bioavailability in man and is safe and...

2008-05-06 06:00:47

Tranzyme Pharma today announced that Dr. Philippa Charlton has joined the Company as Medical Director, Clinical Development, a newly created position. In this new position, Dr. Charlton will play a pivotal role in the planning and execution of advanced clinical programs for the company's lead compounds, TZP-101 and TZP-102. TZP-101 is an intravenous ghrelin agonist currently undergoing Phase IIb trials for the treatment of post-operative ileus (POI) and severe gastroparesis. TZP-102 is an...