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Latest TRPV Stories

chili peppers for tumors
2014-08-04 03:30:04

University of California, San Diego Health System Researchers at the University of California, San Diego School of Medicine report that dietary capsaicin – the active ingredient in chili peppers – produces chronic activation of a receptor on cells lining the intestines of mice, triggering a reaction that ultimately reduces the risk of colorectal tumors. The findings are published in the August 1, 2014 issue of The Journal of Clinical Investigation. The receptor or ion channel,...

Sunburn Pain May One Day Be A Thing Of The Past
2013-08-06 05:55:59

Susan Bowen for redOrbit.com - Your Universe Online According to new research, we could have a future free of sunburn pain. A new study shows how we have a molecule in our epidermis that creates our bodies' reaction to sun exposure. The molecule is called TRPV4, and by blocking this molecule, researchers were able to protect skin from the pain of sunburn. The study was published in the Proceedings of the National Academy of Sciences. It might also be helpful in mitigating other types of...

Study Finds Hot And Cold Senses Interact
2013-04-09 10:20:59

University of North Carolina Health Care A study from the University of North Carolina School of Medicine offers new insights into how the nervous system processes hot and cold temperatures. The research led by neuroscientist Mark J. Zylka, PhD, associate professor of cell biology and physiology, found an interaction between the neural circuits that detect hot and cold stimuli: cold perception is enhanced when nerve circuitry for heat is inactivated. "This discovery has implications for...

2012-08-13 14:53:53

Pathway describes how alpha hydroxyl acids cause skin exfoliation A team of investigators from UC Davis and Peking University have discovered a mechanism that may explain how alpha hydroxyl acids (AHAs) -- the key ingredient in cosmetic chemical peels and wrinkle-reducing creams -- work to enhance skin appearance. An understanding of the underlying process may lead to better cosmetic formulations as well as have medical applications. The findings were published in the Journal of...

2012-03-02 13:39:23

Heat-sensitive proteins assembled in different combinations distinguish temperatures, from a warm handshake to spicy foods The winter sun feels welcome, but not so a summer sunburn. Research over the past 20 years has shown that proteins on the surface of nerve cells enable the body to sense several different temperatures. Now scientists have discovered how just a few of these proteins, called ion channels, distinguish perhaps dozens of discrete temperatures, from mildly warm to very hot....

2011-06-29 13:01:42

The surprising finding in skin cells could lead to better drugs Scientists from The Scripps Research Institute have identified a surprising new molecular pathway in skin cells that is involved in wound-healing and sensory communication. The new study, published in Nature Communications on June 28, 2011, shows that in this process skin cells produce nitric oxide, a versatile signaling molecule involved in temperature-sensing and wound-healing. This alternative, oxygen-independent mode of...

2011-06-16 07:00:00

SAN MATEO, Calif., June 16, 2011 /PRNewswire/ -- NeurogesX, Inc. (Nasdaq: NGSX), a biopharmaceutical company focused on developing and commercializing novel pain management therapies, today announced the completion of patient enrollment in its Phase 2 clinical study of NGX-1998, a topical liquid formulation of high-concentration capsaicin, in patients with postherpetic neuralgia (PHN). NGX-1998 is being developed to provide safety, efficacy and tolerability that is at least comparable to...

2011-04-28 07:00:00

SAN MATEO, Calif., April 28, 2011 /PRNewswire/ -- NeurogesX, Inc. (Nasdaq: NGSX), a biopharmaceutical company focused on developing and commercializing novel pain management therapies, today announced that it has received a Notice of Allowance from the U.S. Patent and Trademark Office for its patent entitled, "Methods and Compositions for Administration of TRPV1 Agonists." The allowed claims include method of use, formulation and system claims. The patent scheduled to issue from this...

2011-04-27 13:24:11

Research at Children's National uncovers an unknown side effect of a promising drug for acute chronic pain Pain researchers from the Sheikh Zayed Institute for Pediatric Surgical Innovation at Children's National Medical Center have discovered that resiniferatoxin, a drug that has shown early promise as an option for chronic, severe pain sufferers, may decrease the body's ability to fight off bacterial infections, particularly sepsis. The study, which appears in the May 1 edition of the...

2011-04-08 13:28:48

Functional change ('modal shift') of the TRP channel through evolution The animals on the earth have adapted themselves to the environmental temperature changes such as hot in deserts, or cold in the glacial epochs. However, the molecular mechanism for adaptation to thermal environments in the evolutionary process involving temperature sensors was not well understood. Professor Makoto Tominaga and Assistant Professor Shigeru Saito at The National Institute for Physiological Sciences (Okazaki...


Word of the Day
mallemaroking
  • Nautical, the visiting and carousing of sailors in the Greenland ships.
This word is apparently from a confusion of two similar Dutch words: 'mallemerok,' a foolish woman, and 'mallemok,' a name for some persons among the crew of a whaling vessel.