Latest TRPV1 Stories

ABBOTT PARK, Ill., Nov. 12 /PRNewswire-FirstCall/ -- Abbott (NYSE: ABT) announced today a definitive agreement to acquire the global rights to PanGenetics BV's PG110 fully humanized antibody to Nerve Growth Factor (NGF), expanding the company's pain care portfolio and leveraging its expertise in biologics. PG110 is a novel biologic in Phase I clinical trial development that targets NGF for the treatment of chronic pain. NGF is released at sites of tissue damage and inflammation, and plays...

Scientists investigating the cough reflex have discovered a new group of molecules on the surface of nerve cells that make us cough when irritated.The findings, to be presented at the British Pharmacological Society's Summer Meeting in Edinburgh this week, could lead to new drugs to treat  cough, which when chronic affects about 10% of the UK population."Cough is the commonest symptom for which medical advice is sought and accounts for over half of new patient consultations to a GP," said...

General anaesthetic can make the pain of operations worse for patients recovering after surgery by activating the body's "mustard receptors", researchers have found. Many of the drugs that send surgical patients to sleep are known to make them more sensitive to pain when they wake up. Scientists now believe they have discovered the reason for the side effect. The findings may help researchers develop new anaesthetics that are kinder to recovering patients. General anaesthetics all suppress...

Anesthetics given to patients during surgery could cause an increase in pain following the procedure, according a new study.Published in the June 23 issue of the Proceedings of the National Academy of Sciences, the study is the first to scientifically explain what doctors have noticed in clinics, researchers said. They hope their findings will lead to the development of new anesthetics that don't cause post-surgical pain.Gerard Ahern of Georgetown University Medical Center in Washington...

PROVIDENCE, R.I. [Brown University] "” Scientists have long known that the nervous system receptor known as TRPV1 can affect sensations of pain in the body. Now a group of Brown University scientists has found that these receptors "“ a darling of drug developers "“ also may play a role in learning and memory in the brain.In surprising new research, published in the journal Neuron, Julie Kauer and her team show that activation of TPRV1 receptors can trigger long-term depression, a...

WASHINGTON -- Devil's Revenge. Spontaneous Combustion. Hot sauces have names like that for a reason. Now scientists are testing if the stuff that makes the sauces so savage can tame the pain of surgery.Doctors are dripping the chemical that gives chili peppers their fire directly into open wounds during knee replacement and a few other highly painful operations.Don't try this at home: These experiments use an ultra-purified version of capsaicin to avoid infection - and the volunteers are...