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Latest TRPV1 Stories

2011-02-02 01:16:50

Research by a Barrow Neurological Institute scientist on the thermoregulatory effects of a receptor more commonly studied for its role in pain is the cover story in the Feb. 2 issue of the Journal of Neuroscience. The research was conducted by an international team led by Andrej Romanovsky, MD, PhD, Director of the Systemic Inflammation Laboratory (FeverLab), at Barrow, which is a part of St. Joseph's Hospital and Medical Center. The featured research discovers a new role of TRPV1 (transient...

2010-08-31 06:59:00

MUMBAI, India, August 31, 2010 /PRNewswire-FirstCall/ -- - With This Announcement, Glenmark has Clearly Reaffirmed its Position Globally as the Leader in the TRP Space Glenmark Pharmaceuticals today announced the discovery of a Novel Chemical Entity(NCE) 'GRC 17536'. The new NCE program is targeting TRPA1 receptor antagonists for pain and respiratory disorders. TRPA1 belongs to Transient Receptor Potential (TRP) family of ion channels, which have generated a lot of interest as...

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2010-08-04 12:30:00

For those with high blood pressure, chili peppers might be just what the doctor ordered, according to a study reported in the August issue of Cell Metabolism, a Cell Press publication. While the active ingredient that gives the peppers their heat"”a compound known as capsaicin"”might set your mouth on fire, it also leads blood vessels to relax, the research in hypertensive rats shows. "We found that long-term dietary consumption of capsaicin, one of the most abundant components in...

2010-02-09 14:52:10

Research led by a scientist at Barrow Neurological Institute at St. Joseph's Hospital and Medical Center has opened the door for the advancement of a new category of painkillers, called TRPV1 antagonists. These drugs block the transient receptor potential vannilloid-1 (TRPV1) channel, which is the same receptor responsible for the sensation of hotness from hot peppers. However, clinical trials have revealed that TRPV1 antagonists cause hyperthermia-"“ a dangerous, fever-like rise in...

2009-11-12 08:00:00

ABBOTT PARK, Ill., Nov. 12 /PRNewswire-FirstCall/ -- Abbott (NYSE: ABT) announced today a definitive agreement to acquire the global rights to PanGenetics BV's PG110 fully humanized antibody to Nerve Growth Factor (NGF), expanding the company's pain care portfolio and leveraging its expertise in biologics. PG110 is a novel biologic in Phase I clinical trial development that targets NGF for the treatment of chronic pain. NGF is released at sites of tissue damage and inflammation, and...

2009-07-08 09:39:29

Scientists investigating the cough reflex have discovered a new group of molecules on the surface of nerve cells that make us cough when irritated.The findings, to be presented at the British Pharmacological Society's Summer Meeting in Edinburgh this week, could lead to new drugs to treat  cough, which when chronic affects about 10% of the UK population."Cough is the commonest symptom for which medical advice is sought and accounts for over half of new patient consultations to a GP,"...

2008-06-25 00:02:50

General anaesthetic can make the pain of operations worse for patients recovering after surgery by activating the body's "mustard receptors", researchers have found. Many of the drugs that send surgical patients to sleep are known to make them more sensitive to pain when they wake up. Scientists now believe they have discovered the reason for the side effect. The findings may help researchers develop new anaesthetics that are kinder to recovering patients. General anaesthetics all...

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2008-06-24 10:59:45

Anesthetics given to patients during surgery could cause an increase in pain following the procedure, according a new study. Published in the June 23 issue of the Proceedings of the National Academy of Sciences, the study is the first to scientifically explain what doctors have noticed in clinics, researchers said. They hope their findings will lead to the development of new anesthetics that don't cause post-surgical pain. Gerard Ahern of Georgetown University Medical Center in...

2008-03-13 17:10:00

PROVIDENCE, R.I. [Brown University] "” Scientists have long known that the nervous system receptor known as TRPV1 can affect sensations of pain in the body. Now a group of Brown University scientists has found that these receptors "“ a darling of drug developers "“ also may play a role in learning and memory in the brain. In surprising new research, published in the journal Neuron, Julie Kauer and her team show that activation of TPRV1 receptors can trigger long-term...

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2007-10-29 16:30:00

WASHINGTON -- Devil's Revenge. Spontaneous Combustion. Hot sauces have names like that for a reason. Now scientists are testing if the stuff that makes the sauces so savage can tame the pain of surgery. Doctors are dripping the chemical that gives chili peppers their fire directly into open wounds during knee replacement and a few other highly painful operations. Don't try this at home: These experiments use an ultra-purified version of capsaicin to avoid infection - and the volunteers are...


Word of the Day
glogg
  • Scandinavian punch made of claret and aquavit with spices and raisins and orange peel and sugar.
This word comes from the Swedish 'glogg,' which is an alteration of 'glodgat,' mulled (wine).
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