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Latest TRPV3 Stories

2012-08-13 14:53:53

Pathway describes how alpha hydroxyl acids cause skin exfoliation A team of investigators from UC Davis and Peking University have discovered a mechanism that may explain how alpha hydroxyl acids (AHAs) -- the key ingredient in cosmetic chemical peels and wrinkle-reducing creams -- work to enhance skin appearance. An understanding of the underlying process may lead to better cosmetic formulations as well as have medical applications. The findings were published in the Journal of...

2011-06-29 13:01:42

The surprising finding in skin cells could lead to better drugs Scientists from The Scripps Research Institute have identified a surprising new molecular pathway in skin cells that is involved in wound-healing and sensory communication. The new study, published in Nature Communications on June 28, 2011, shows that in this process skin cells produce nitric oxide, a versatile signaling molecule involved in temperature-sensing and wound-healing. This alternative, oxygen-independent mode of...

2011-04-08 13:28:48

Functional change ('modal shift') of the TRP channel through evolution The animals on the earth have adapted themselves to the environmental temperature changes such as hot in deserts, or cold in the glacial epochs. However, the molecular mechanism for adaptation to thermal environments in the evolutionary process involving temperature sensors was not well understood. Professor Makoto Tominaga and Assistant Professor Shigeru Saito at The National Institute for Physiological Sciences (Okazaki...

2010-04-16 09:04:16

New findings about a temperature sensor in the skin could lead to novel approaches to controlling excess hair growth and treating skin cancers. The common denominator that unites these seemingly unrelated processes is a versatile protein called TRPV3. The new research shows that in addition to serving as a temperature sensor, the protein is important for proper hair growth and skin health. The work, by University of Michigan cell biologist Haoxing Xu and colleagues, is described in a paper...

2010-04-16 08:04:15

Loss of TRPV3 leads to thinner, less intact skin Skin and hair follicles are constantly renewed in the body, maintained by specialized stem cells. New research from Children's Hospital Boston identifies a small cellular channel that regulates skin and hair growth and that could be targeted with small-molecule drugs, potentially treating variety of skin conditions, as well as thinning hair or unwanted hair growth. Findings appear in the April 16 issue of Cell. Several known factors regulate...

2009-10-08 14:26:30

Another role of the energy source A Japanese research group led by Prof. Makoto Tominaga and Dr. Sravan Mandadi (National Institute for Physiological Sciences: NIPS) found that ATP plays a key role in transmitting temperature information from skin keratinocytes to afferent sensory neurons. Their findings were presented in the Pflugers Archiv European Journal of Physiology published on October 2009. Hazardous temperatures (extreme hot or cold) are known to be detected by the...


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  • Color; hue; complexion.
This word is Middle English in origin.
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