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Latest Trypanosoma brucei Stories

New Hope For Sleeping Sickness Drug
2012-11-30 12:32:48

Connie K. Ho for redOrbit.com — Your Universe Online Scientists from the Helmholtz Association of German Research Centers and the Department of Energy´s (DOE) SLAC National Accelerator Laboratory recently revealed that X-rays could provide information on a novel biological structure that could possibly be developed into a sleeping sickness drug. The findings were discovered with the help of a free-electron laser that is considered the most powerful in the world. Sleeping...

2012-05-22 21:28:08

Lies Van Nieuwenhove, researcher at the Antwerp Institute of Tropical Medicine, has produced proteins imitating typical parts of the sleeping sickness parasite. They can be used in more efficient diagnostic tests, without the need for culturing dangerous parasites. Each year many thousands of Africans contract sleeping sickness. The cause is a unicellular parasite, a trypanosome, which is transmitted by the bite of tsetse flies. First the parasite multiplies in blood and lymph, while...

2012-01-26 02:11:22

Research led by scientists at the London School of Hygiene & Tropical Medicine has exploited a revolutionary genetic technique to discover how human African Trypanosomiasis (HAT) drugs target the parasite which causes the disease. The new knowledge could help lead to the development of better treatments for the tens of thousands of people in sub-Saharan Africa who are affected each year. The findings, published in Nature, are based on the simultaneous analysis of thousands of genes and...

2010-12-13 14:54:23

Research presented at American Society of Cell Biology's 50th annual meeting in Philadelphia Long considered a freewheeling loner, the Trypanosoma brucei parasite responsible for African sleeping sickness has revealed a totally unexpected social side, opening a potential chink in the behavioral armor of this and other supposedly solitary human parasites, according to research presented at the American Society for Cell Biology's 50th Annual Meeting in Philadelphia. "The concept of bacteria...

2010-05-11 11:55:00

A new bacterial species, found in the gut of the fly that transmits African sleeping sickness, could be engineered to kill the parasite that causes the disease. The study, published in the International Journal of Systematic and Evolutionary Microbiology, could lead to new approaches to control this fatal infection that is becoming resistant to drug therapy. Scientists from IRD, the French Research Institute for Development in Montpellier, France isolated the novel bacterium from the midgut...

2009-04-16 07:39:43

Double-stranded DNA breaks are the key to Trypanosoma brucei's getaway planThe parasite Trypanosoma brucei, which causes African sleeping sickness, is like a thief donning a disguise. Every time the host's immune cells get close to destroying the parasite, it escapes detection by rearranging its DNA and changing its appearance. Now, in research to appear in the advance online April 15 issue of Nature, two laboratories at Rockefeller University have joined forces to reveal how the parasite...

2005-07-14 16:25:00

Scientists have sequenced and compared the genomes of three of the parasites responsible for sleeping sickness, Chagas disease and leishmaniasis, three devastating diseases of the developing world. These parasites collectively cause disease and death in millions of humans each year, and the new genome sequences provide critical information for drug and vaccine developers, according to new research appearing in the 15 July 2005 issue of the journal Science, published by AAAS, the nonprofit...

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2005-07-14 16:12:19

WASHINGTON -- Scientists have mapped the genes of a trio of parasites that sicken and kill millions in poor countries and found they share a surprising amount of DNA, even though they cause markedly different illnesses and are spread by different insects. The research opens the possibility of finding drugs that would fight all three ancient scourges: African sleeping sickness, Chagas disease and leishmaniasis. Already, scientists have begun using the gene maps to identify possible vaccine...


Word of the Day
malpais
  • The ragged surface of a lava-flow.
'Malpais' translates from Spanish as 'bad land.'