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Last updated on April 18, 2014 at 13:23 EDT

Latest Tubulin Stories

2013-12-04 12:27:03

Agreement encompasses a broad IP estate and library of anti-cancer compounds engineered for improved efficacy and tolerability RALEIGH, N.C. and PITTSBURGH, Dec. 4, 2013 /PRNewswire/ -- FLAG Therapeutics Inc. and Duquesne University today announced an exclusive worldwide licensing agreement for two novel classes of small molecule, water-soluble drugs designed to target and destroy cancer cells: anti-angiogenic/anti-tubulin (AA/AT) compounds and folate-targeted anti-cancer (FTAC)...

2013-09-17 11:09:09

Scientists at The Scripps Research Institute (TSRI) have found a way to make dramatic improvements to the cancer cell-killing power of vinblastine, one of the most successful chemotherapy drugs of the past few decades. The team’s modified versions of vinblastine showed 10 to 200 times greater potency than the clinical drug. Even more significantly, these new compounds overcome the drug resistance that emerges upon treatment relapse, which renders continued or subsequent vinblastine...

2013-09-09 20:31:55

University of Montreal, McGill researchers develop new method to link signaling molecules to target regulators of cell division A team of University of Montreal and McGill University researchers have devised a method to identify how signaling molecules orchestrate the sequential steps in cell division. In an article published online today in the Proceedings of the National Academy of Sciences, the scientists explain how they could track the relationship between signaling molecules and...

2013-02-11 08:25:46

ALBANY, N.Y., Feb. 11, 2013 /PRNewswire/ -- AMRI (NASDAQ: AMRI) announced today that it has signed an exclusive license agreement with Chai Therapeutics, LLC for the development of ALB 109564(a), AMRI's novel tubulin inhibitor compound in late Phase I testing for the treatment of cancer. This agreement follows the exercise of an option to license the intellectual property, which was granted in March 2012 by AMRI to Bessor Pharma, LLC, a translational drug development company. Chai...

Mechanism For Organ Placement Shared By Human Cells, Plants, Worms And Frogs
2012-07-17 10:19:48

New research identifies special protein that determines what goes where As organisms develop, their internal organs arrange in a consistent asymmetrical pattern--heart and stomach to the left, liver and appendix to the right. But how does this happen? Biologists at Tufts University have produced the first evidence that a class of proteins that make up a cell's skeleton -- tubulin proteins -- drives asymmetrical patterning across a broad spectrum of species, including plants, nematode...

2012-04-19 20:13:28

New research findings show how it may be possible to render cancer tumors harmless without affecting the other cells and tissues in the body. The findings apply to cancers including breast, lung and bowel cancer. The study was carried out at Lund University in Sweden. Many of the most common chemotherapy drugs used to treat cancer have serious side effects because they not only affect the cells in the cancer tumor, but also the cells in the rest of the body. Researchers at Lund...

2011-04-19 14:33:34

Novel way of studying cancer may inspire new treatments Many of the newest weapons in the war on cancer come in the form of personalized therapies that can target specific changes in an individual's tumor. By disrupting molecular processes in tumor cells, these drugs can keep the tumor from growing and spreading. At the forefront of this work are Binghamton University researchers, Susan Bane, and Susannah Gal, who are deploying a new tool in their study of an enzyme called tubulin tyrosine...

2011-03-07 21:25:14

Patients with Parkinson's disease (PD) suffer a specific loss of dopaminergic neurons from the midbrain region that controls motor function. The exact mechanism of this selective neurodegeneration is unclear, though many lines of evidence point to dysfunctional mitochondrial complex I as one root cause of the disease. Yet new research now suggests that defective regulation of microtubules may be responsible for at least some cases of PD. The study appears in the March 7 issue of The Journal...

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2010-10-15 08:16:31

Unless you are in a field of study related to cell biology, you most likely have never heard of Ndc80. Yet this protein complex is essential to mitosis, the process by which a living cell separates its chromosomes and distributes them equally between its two daughter cells. Now, through a combination of cryo-electron microscopy and three-dimensional image reconstruction, a team of researchers with the Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC)...

2010-10-11 14:30:52

Researchers at the Carnegie Institution for Science, with colleagues at the Nara Institute of Science and Technology, observed for the first time a fundamental process of cellular organization in living plant cells: the birth of microtubules by studying recruitment and activity of individual protein complexes that create the cellular protein network known as the microtubule cytoskeleton"”the scaffolding that provides structure and ultimately form and shape to the cell. These fundamental...