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Latest Tubulin Stories

2014-06-16 09:44:31

NIH Study may advance understanding of how brain cell tubes are modified under normal and disease conditions In a new study, scientists at the National Institutes of Health took a molecular-level journey into microtubules, the hollow cylinders inside brain cells that act as skeletons and internal highways. They watched how a protein called tubulin acetyltransferase (TAT) labels the inside of microtubules. The results, published in Cell, answer long-standing questions about how TAT...

2014-05-26 12:36:49

Ecole Polytechnique Fédérale de Lausanne Like our own bodies, cells have their own skeletons called 'cytoskeletons' and are made of proteins instead of bones. These network-like structures maintain the cell's shape, provide mechanical support, and are involved in critical processes of the cell's lifecycle. The cytoskeleton is an object of intense scientific and medical research, which often requires being able to observe it directly in cells. Ideally, this would involve...

2014-05-23 11:04:04

Berkeley Lab Berkeley Lab Researchers Take an Atomic-Scale Look at Key Cellular Protein A pathway to the design of even more effective versions of the powerful anti-cancer drug Taxol has been opened with the most detailed look ever at the assembly and disassembly of microtubules, tiny fibers of tubulin protein that form the cytoskeletons of living cells and play a crucial role in mitosis. Through a combination of high-resolution cryo-electron microscopy (cryo-EM) and new methodology for...

2013-09-17 11:09:09

Scientists at The Scripps Research Institute (TSRI) have found a way to make dramatic improvements to the cancer cell-killing power of vinblastine, one of the most successful chemotherapy drugs of the past few decades. The team’s modified versions of vinblastine showed 10 to 200 times greater potency than the clinical drug. Even more significantly, these new compounds overcome the drug resistance that emerges upon treatment relapse, which renders continued or subsequent vinblastine...

2013-09-09 20:31:55

University of Montreal, McGill researchers develop new method to link signaling molecules to target regulators of cell division A team of University of Montreal and McGill University researchers have devised a method to identify how signaling molecules orchestrate the sequential steps in cell division. In an article published online today in the Proceedings of the National Academy of Sciences, the scientists explain how they could track the relationship between signaling molecules and...

Mechanism For Organ Placement Shared By Human Cells, Plants, Worms And Frogs
2012-07-17 10:19:48

New research identifies special protein that determines what goes where As organisms develop, their internal organs arrange in a consistent asymmetrical pattern--heart and stomach to the left, liver and appendix to the right. But how does this happen? Biologists at Tufts University have produced the first evidence that a class of proteins that make up a cell's skeleton -- tubulin proteins -- drives asymmetrical patterning across a broad spectrum of species, including plants, nematode...

2012-04-19 20:13:28

New research findings show how it may be possible to render cancer tumors harmless without affecting the other cells and tissues in the body. The findings apply to cancers including breast, lung and bowel cancer. The study was carried out at Lund University in Sweden. Many of the most common chemotherapy drugs used to treat cancer have serious side effects because they not only affect the cells in the cancer tumor, but also the cells in the rest of the body. Researchers at Lund...

2011-04-19 14:33:34

Novel way of studying cancer may inspire new treatments Many of the newest weapons in the war on cancer come in the form of personalized therapies that can target specific changes in an individual's tumor. By disrupting molecular processes in tumor cells, these drugs can keep the tumor from growing and spreading. At the forefront of this work are Binghamton University researchers, Susan Bane, and Susannah Gal, who are deploying a new tool in their study of an enzyme called tubulin tyrosine...


Word of the Day
omadhaun
  • A fool; a simpleton: a term of abuse common in Ireland and to a less extent in the Gaelic-speaking parts of Scotland.
This word is partly Irish in origin.