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Latest Tumor hypoxia Stories

2008-09-24 03:00:12

By Yeom, Chan Joo Chung, June-Key; Kang, Joo Hyun; Jeon, Yong Hyun; Kim, Kwang Il; Jin, Yong Nan; Lee, You Mie; Jeong, Jae Min; Lee, Dong Soo Hypoxia-inducible factor-1 (HIF-1) is a transcription factor of hypoxic response in cancer cells and is associated with tumor progression, angiogenesis, metastasis, and resistance to therapy. We assessed whether the human sodium iodide symporter (NIS) reporter systems can be used to visualize transcriptional activation of HIF- 1 in C6 glioma. Methods:...

2008-09-16 09:00:15

REDWOOD CITY, Calif., Sept. 16, 2008 (GLOBE NEWSWIRE) -- Threshold Pharmaceuticals, Inc. (Nasdaq:THLDD), today announced that it has initiated a Phase 1/2 clinical trial of TH-302 in combination with doxorubicin in patients with advanced soft tissue sarcoma. TH-302 is a proprietary Hypoxia-Activated Prodrug (HAP) that specifically targets tumor hypoxia. "The treatment of soft tissue sarcomas continues to be a difficult challenge. New therapeutic and novel agents are required to improve the...

2008-08-12 09:00:38

REDWOOD CITY, Calif., Aug. 12, 2008 (PRIME NEWSWIRE) -- Threshold Pharmaceuticals, Inc. (Nasdaq:THLD), today announced that it has initiated a clinical trial of TH-302 in combination with various chemotherapeutic agents in patients with advanced solid tumors. TH-302 is a proprietary Hypoxia-Activated Prodrug (HAP) that specifically targets tumor hypoxia. "Targeting tumor hypoxia is an exciting area of cancer research, and may offer great promise to patients with a wide variety of cancers,"...

2008-08-06 09:00:11

Pro-Pharmaceuticals, Inc. (AMEX: PRW), a bio-pharmaceutical company developing proprietary polysaccharide-based therapeutic compounds in the treatment of cancer and fibrosis, today announced that a pre-Investigational New Drug (IND) meeting with the U.S. Food and Drug Administration ("FDA") is scheduled for October to present the clinical development plan for a anti-hypoxia drug to be used in combination with DAVANAT(R) and 5-FU to treat advanced solid tumors, including head and neck, breast...

2008-07-24 09:01:14

REDWOOD CITY, Calif., July 24, 2008 (PRIME NEWSWIRE) -- Threshold Pharmaceuticals, Inc. (Nasdaq:THLD), today announced that Herbert Hurwitz, M.D. has joined the Company's Scientific Advisory Board (SAB). Dr. Hurwitz is an Associate Professor of Medicine at Duke University Medical Center and a medical oncologist at the Duke Comprehensive Cancer Center. "Tumor hypoxia is a promising area that is gaining a great deal of attention among the medical research community," said Herbert Hurwitz, M.D....

2008-07-15 09:00:16

Pro-Pharmaceuticals, Inc. (AMEX: PRW), a biopharmaceutical company developing proprietary polysaccharide-based therapeutic compounds in the treatment of cancer and fibrosis, has requested a pre-Investigational New Drug (IND) meeting with the U.S. Food and Drug Administration ("FDA") to define the regimen for an Oxygen-based product (EZ-646) to be used with Galactomannan-C (DAVANAT(R)) and Fluorouracil (5-FU) to treat all solid tumors, including new indications such as head & neck and...


Word of the Day
drawcansir
  • A blustering, bullying fellow; a pot-valiant braggart; a bully.
This word is named for Draw-Can-Sir, a character in George Villiers' 17th century play The Rehearsal.
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