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Last updated on April 16, 2014 at 17:34 EDT

Latest Tumor necrosis factor-alpha Stories

2012-11-14 12:27:03

ATLANTA, Nov. 14, 2012 /PRNewswire/ -- UCB announced today results from the RAPID(TM)-PsA study at the American College of Rheumatology's (ACR) 2012 Annual Scientific Meeting in Washington, D.C., U.S. Data presented from this Phase 3 study showed that compared to placebo, certolizumab pegol provided improvements in the signs and symptoms of psoriatic arthritis (PsA) in adult patients with and without prior anti-TNF (tumor necrosis factor) exposure. Patients in this study could have received...

2012-11-13 08:33:42

BRUSSELS, Nov. 13, 2012 /PRNewswire/ -- UCB announced extensive results from the Phase 3 study - RAPID(TM)-axSpA - at the American College of Rheumatology's (ACR) 2012 Annual Scientific Meeting in Washington D.C., U.S. RAPID(TM)-axSpA enrolled patients with active axial spondyloarthritis (axSpA), including patients with ankylosing spondylitis (AS) and axSpA without radiographic evidence of AS (non-radiographic axSpA [nr-axSpA]). The study showed that...

2012-09-17 22:21:22

LEXINGTON, Mass., Sept. 18, 2012 /PRNewswire/ -- Avaxia Biologics, Inc., a privately-held biotechnology company developing oral antibody drugs that act locally within the digestive tract, announced today that the company was awarded U.S. Patent 8,268,971, entitled "Antibody Therapy for Modulating Function of Intestinal Receptors and Methods of Treating Diabetes and Obesity." The patent covers milk derived antibody compositions that specifically target and modulate an apical intestinal...

2012-08-21 21:47:57

Use of tumor necrosis factor (TNF) inhibitors for treatment of psoriasis is associated with a significantly reduced risk for heart attack (myocardial infarction) compared to other forms of treatment, according to a report published Online First by Archives of Dermatology, a JAMA Network publication. "The effect of systemic treatment for psoriasis on cardiovascular disease has been largely unexplored," the authors write as background information in the study. "The primary objective of this...

2012-08-07 07:41:59

Adalimumab (an anti-tumor necrosis factor [TNF] antibody) is effective in maintaining remission in certain pediatric patients with Crohn's disease, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association. Steroids are commonly used in Crohn's disease, but can stunt growth and delay puberty. Incidence of this disease, which causes intestinal inflammation, is on the rise in children. This study is the largest double-blind study of...

2012-07-23 18:20:31

MELBOURNE, Australia, July 23, 2012 /PRNewswire/ -- Key Points: * Intravenous injection of Mesenchymal Precursor Cells (MPCs) resulted in selective migration to inflamed joints and lymph nodes in a sheep model of Rheumatoid Arthritis (RA) * A single intravenous injection of allogeneic, or "off-the-shelf", MPCs significantly reduced synovial tissue levels of TNF-alpha, IL-6, and IL-17, and reduced mononuclear cell infiltration * Reduced cytokine and inflammatory cell levels were...

2012-06-28 20:18:49

Inhibiting immune response early on could speed treatment time, prevent relapse Inhibiting a key immune response in mice during initial multi-drug treatment for tuberculosis could – paradoxically – shorten treatment time for the highly contagious lung infection according to new research from Johns Hopkins Children's Center and the Center for TB Research. Shorter duration of drug therapy is key, researchers say, to increase treatment compliance for the growing global health...

2012-06-25 23:01:25

A novel anti-inflammatory approach produced a significant reduction in stroke size and neural deficit in an animal model. The animal study follows publication by the INR (CNS Drugs, 2011. 25(2):145) of pioneering human data that utilized a related anti-inflammatory approach and underscores the promise of this concept. Source: Institute of Neurological Recovery, Los Angeles Los Angeles, California (PRWEB) June 25, 2012 New evidence supporting the potential value of a new type of...

2012-05-14 20:22:03

A small, external bioreactor holding human cells pumped out an anti-inflammatory protein to prevent organ damage and other complications in a rat with acute inflammation caused by bacterial products in a model of sepsis, according to a report from researchers at the University of Pittsburgh School of Medicine and the McGowan Institute for Regenerative Medicine. The findings were published today in the inaugural issue of Disruptive Science and Technology. Inflammation is a necessary...

2012-05-01 11:40:28

High-dose steroids found to significantly increase infection risk Children with juvenile idiopathic arthritis (JIA) have higher rates of hospitalized bacterial infection than children without JIA according to an observational study appearing in Arthritis & Rheumatism, a journal published by Wiley-Blackwell on behalf of the American College of Rheumatology (ACR). The findings show that the risk of infection among JIA patients was significantly increased with use of high-dose...