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Latest Tumor necrosis factor-alpha Stories

2010-12-01 07:00:00

BURLINGTON, Mass., Dec. 1, 2010 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that although Amgen/Pfizer/Stiefel's Enbrel will remain the most-prescribed first-line biologic for moderate-to-severe psoriasis, it will lose market share at this line of therapy to agents in the IL-12/IL-23 inhibitors drug class, namely Centocor Ortho Biotech/Janssen-Cilag's Stelara. Surveyed U.S. dermatologists...

2010-11-09 07:05:00

ATLANTA, Nov. 9, 2010 /PRNewswire/ -- The addition of Cimzia® (certolizumab pegol; CZP) to current therapy was associated with a rapid clinical response, improved function and reduced disease activity in a diverse group of adult rheumatoid arthritis (RA) patients reflecting those seen in daily clinical practice (including those with prior TNF-inhibitor use). These positive clinical trial data were presented during the American College of Rheumatology's (ACR) 2010 Annual...

2010-11-08 07:15:00

LOS ANGELES, Nov. 8, 2010 /PRNewswire-USNewswire/ -- Three new studies provide converging evidence pointing to a new therapeutic target in Alzheimer's Disease(AD). These studies, from independent academic centers in the U.S., England, and China, point to excess levels of a protein called TNF as a key factor in AD. TNF is an immune signaling protein that regulates both inflammation and neuronal communication in the brain. As a target it is radically different from the amyloid plaques that...

2010-11-08 07:08:00

ATLANTA, Nov. 8, 2010 /PRNewswire/ -- Patients with active moderate to severe rheumatoid arthritis (RA) inadequately responding to either etanercept (Enbrel(®)) or adalimumab (Humira(®)) and who were actively switched to REMICADE(®) (infliximab) demonstrated significant improvement from baseline at week 10, and sustained response through week 26 in an open label study. These week 26 results from the RESTART study were presented for the...

2010-11-08 08:13:22

(Ivanhoe Newswire) -- Remember that groggy, barely conscious feeling you had following a surgical procedure?  Chances are you don't remember much of the experience, and that's because of a condition called "post-operative cognitive decline." Anywhere from 28 to 92 percent of hospitalized patients suffer from short-term memory loss and general delirium.  Researchers at Imperial College London and the University of California, San Francisco have discovered a possible treatment for the...

2010-11-04 01:11:55

Proteasome inhibitor reduces inflammation and promotes bone healing in arthritis models A new study by Greek researchers suggests that the biologic drug bortezomib (Velcade), a proteasome inhibitor used to treat multiple myeloma (bone marrow cancer), may represent a promising treatment for rheumatoid arthritis (RA). In this study, bortezomib displayed favorable effects in an animal model of inflammatory arthritis that mimics RA, in reducing disease severity and inflammation, and promoting...

2010-11-03 08:48:00

EXTON, Pa., Nov. 3, 2010 /PRNewswire/ -- Bio-Trends is pleased to announce the publication of a new syndicated report, TreatmentTrends®: Rheumatoid Arthritis Q3 2010. This report covers the use of biologics for the treatment of rheumatoid arthritis (RA). The report, part of a quarterly series, focuses on current and future use of biologic agents, patient market share, perceived strengths and weaknesses of the key brands, barriers to broader usage, sales force performance...

2010-11-03 07:00:00

BURLINGTON, Mass., Nov. 3, 2010 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that, for the treatment of psoriatic arthritis, Abbott/Eisai's Humira has emerged as the market leader, garnering sales of more than $500 million in 2009 in the United States, France, Germany, Italy, Spain, United Kingdom and Japan. Despite Humira's later entry to the psoriatic arthritis market behind that of...

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2010-11-02 08:46:43

Anti-inflammatory drugs currently used to treat diseases such as rheumatoid arthritis may also help prevent cognitive problems after surgery, according to a new study by researchers at Imperial College London and University of California, San Francisco (UCSF). The research also reveals for the first time that a specific inflammatory response in the brain may explain why many patients experience memory loss or other forms of cognitive dysfunction after surgery or critical illness. The...

2010-10-21 15:05:00

FRAZER, Pa., Oct. 21 /PRNewswire-FirstCall/ -- Cephalon, Inc. (Nasdaq: CEPH) announced today that it has exercised its option to acquire BioAssets Development Corporation (BDC), following receipt of interim data from a Phase II placebo-controlled proof-of-concept study evaluating epidural administration of a tumor necrosis factor (TNF) inhibitor for the treatment of sciatica in 45 patients. Sciatica is a neuropathic inflammatory pain condition that occurs when the sciatic nerve is...


Word of the Day
snash
  • To talk saucily.
  • Insolent, opprobrious language; impertinent abuse.
This word is Scots in origin and probably imitative.