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Latest Tumor necrosis factors Stories

2012-06-25 23:01:25

A novel anti-inflammatory approach produced a significant reduction in stroke size and neural deficit in an animal model. The animal study follows publication by the INR (CNS Drugs, 2011. 25(2):145) of pioneering human data that utilized a related anti-inflammatory approach and underscores the promise of this concept. Source: Institute of Neurological Recovery, Los Angeles Los Angeles, California (PRWEB) June 25, 2012 New evidence supporting the potential value of a new type of...

2012-04-12 22:25:16

Researchers at Boston University School of Medicine (BUSM) have identified a gene that plays a key role in regulating inflammatory response and homeostasis. These findings could help lead to the development of innovative methods to reduce the inflammation associated with cancer, type 2 diabetes and other diseases. The study, which was led by Valentina Perissi, PhD, assistant professor of biochemistry at BUSM, was done in collaboration with the Howard Hughes Medical Institute (HHMI) at the...

2012-01-24 21:49:04

Glioblastoma, a lethal brain cancer, is one of the most resistant to available therapies and patients typically live approximately 15 months. Previous research has focused on the activation of the apoptosis, or cell death, pathway using therapeutic agents such as tumor necrosis factor-related apoptosis-inducing ligand (TRAIL); however, the vast majority of these experiments have been stymied by resistance. "Scientists in this field have been hoping to treat this cancer with this new...

2011-12-27 08:46:14

Researchers of VIB and UGent have discovered a new approach to preventing septic shock, an often fatal extreme inflammatory reaction of the body. It is the most frequent cause of death at intensive care departments in hospitals. In sepsis, acute inflammation is attended by low blood pressure and blood clots, causing the organs to stop working. Only recently, the Brazilian football legend Socrates, died of the consequences of this condition. In a new study in the top journal Immunity, Peter...

2011-12-22 15:29:05

Sepsis, a form of systemic inflammation, is the leading cause of death in critically ill patients. Sepsis is linked with massive cell death; however, the specific mechanisms involved in the lethality of sepsis are unclear. Now, a new study published by Cell Press in the December 23rd issue of the journal Immunity finds that inhibition of a specific cell death pathway called "necroptosis" protected mice from lethal inflammation. The research may lead to new therapeutic interventions for fatal...

2011-09-08 09:46:14

Malignancies associated with tumor necrosis factor inhibitors in registries and prospective observational studies: a systematic review and meta analysis Biological agents used to treat rheumatoid arthritis seem to be associated with an increased risk of skin cancer, indicates a systematic review of published research in the Annals of the Rheumatic Diseases. Inflammatory arthritis has been linked to an increased risk of some cancers, such as lymphoma and lung cancer, but a lower risk of...

2011-05-25 06:43:51

(Ivanhoe Newswire) "“ A powerful pro-inflammatory protein, tumor necrosis factor (TNF), can suppress aspects of inflammation. The identification of the mechanism of how this works could potentially lead to new treatment for rheumatoid arthritis. "Prior to this study, TNF has long been known as a potent pro-inflammatory cytokine, but if you look carefully through the literature, there are hints that it also has some suppressive functions, but nothing was known about the mechanisms," sid...

2011-05-24 06:00:00

MALVERN, Pa., May 24, 2011 /PRNewswire/ -- TetraLogic Pharmaceuticals, a biopharmaceutical company developing novel small molecule drugs to treat cancer, today announced that is has closed a $6 million investment with new investor Nextech Invest Ltd., a Zurich, Switzerland, based oncology focused venture capital fund. Combined with the $37 million Series C closed during 2010, TetraLogic has raised $43 million in the past year. The company is investing the funds to complete Phase 2a...

2011-03-02 20:27:05

Research 'solves a longstanding mystery regarding the regulation of cell death pathways;' could lead to better cancer and autoimmune disease drugs Reporting in Nature, scientists from Thomas Jefferson University have determined that a single protein called FADD controls multiple cell death pathways, a discovery that could lead to better, more targeted autoimmune disease and cancer drugs. Twelve years ago, internationally-known immunologist Jianke Zhang, Ph.D., an associate professor in the...

2011-01-05 07:00:00

MALVERN, Pa., Jan. 5, 2011 /PRNewswire/ -- TetraLogic Pharmaceuticals, a biopharmaceutical company developing novel small molecule drugs to treat cancer, today announced that is has closed the $23 million second tranche of a Series C financing completed in October 2010. The company will use the funds to advance the clinical development of its lead Smac mimetic drug candidate, TL32711. TetraLogic recently completed dosing in the first cohort of a Phase 1b/2a five-arm combination clinical...


Word of the Day
conjunto
  • A style of popular dance music originating along the border between Texas and Mexico, characterized by the use of accordion, drums, and 12-string bass guitar and traditionally based on polka, waltz, and bolero rhythms.
The word 'conjunto' comes through Spanish, from Latin coniūnctus, past participle of coniungere, to join together; see conjoin