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Latest Tumor suppressor gene Stories

2013-03-13 14:48:34

A team of Canadian and international cancer researchers led by Dr. Brenda Gallie at the Princess Margaret Cancer Centre, University Health Network (UHN), has discovered a new type of retinoblastoma, a rapidly developing eye cancer that affects very young babies— a finding that can immediately change clinical practice and optimize care for these children. The finding, published online today in Lancet Oncology, is a breakthrough in recognizing that a single cancer gene (an oncogene)...

2012-08-07 09:56:28

Their Mexican-born counterparts at lesser risk In a large epidemiologic study, researchers at UCLA's Jonsson Cancer Center found that the children of U.S.-born Latina women are at higher risk of having retinoblastoma, a malignant tumor of the retina which typically occurs in children under six. The study, which focused on babies born in California, also found that offspring of older fathers were at greater risk for retinoblastoma, as were children born to women with sexually transmitted...

2012-08-02 15:26:11

The body has a built-in system known as autophagy, or 'self-eating,' that controls how cells live or die. Deregulation of autophagy is linked to the development of human diseases, including neural degeneration and cancer. In a study published online this week in the Proceedings of the National Academy of Sciences, scientists at the Ludwig Institute for Cancer Research in Oxford discovered a critical molecular switch that regulates autophagy. They also studied the links between autophagy...

2012-07-04 22:45:29

As the Genetics Society of America's Model Organism to Human Biology (MOHB): Cancer Genetics Meeting in Washington, D.C. drew to a close, it was clear that the mantra for drug discovery to treat cancers in the post-genomic era is pathways. Pathways are ordered series of actions that occur as cells move from one state, through a series of intermediate states, to a final action. Because model organisms — fruit flies, roundworms, yeast, zebrafish and others — are related to...

2012-07-02 23:13:22

A study conducted at Boston University School of Medicine (BUSM) demonstrates an effective combination therapy for breast cancer cells in vitro. The findings, published in the July 2012 issue of Anticancer Research, raise the possibility of using this type of combination therapy for different forms of breast cancer, including those that develop resistance to chemotherapy and other treatments. The study was led by researchers at the Boston University Cancer Center. Sibaji Sarkar, PhD,...

2012-01-11 21:30:53

Washington University Pediatric Cancer Genome Project findings help solve mystery of retinoblastoma's rapid growth in work that also yields a new treatment target and possible therapy Washington University Pediatric Cancer Genome Project (PCGP) have helped identify the mechanism that makes the childhood eye tumor retinoblastoma so aggressive. The discovery explains why the tumor develops so rapidly while other cancers can take years or even decades to form. The finding also led...

2011-12-13 22:57:01

Chemical disruption to key interaction shown to limit metastasis in test mice Finding ways to counteract or disrupt the invasive nature of cancer cells, called "metastasis," has been a long-term goal of cancer researchers. Now, researchers at Moffitt Cancer Center in Tampa, Fla., have identified an interactive pathway that regulates metastases in some cancers that may be vulnerable to chemical targeting in order to prevent cancer cell proliferation and tumor growth. Ongoing...

2011-11-30 10:42:39

Newly published research explores the role of 14-3-3σ in tumor suppression New research out of McGill University's Goodman Cancer Research Centre provides compelling new evidence that a gene known as 14-3-3σ plays a critical role in halting breast cancer initiation and progression. The study, led by the Dept. of Biochemistry's William J. Muller, will be published online today in the journal Cancer Discovery. The discovery of this new target points to novel...


Word of the Day
jument
  • A beast of burden; also, a beast in general.
'Jument' ultimately comes from the Latin 'jugum,' yoke.
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