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Latest Tumor suppressor genes Stories

2013-04-23 12:06:30

Researchers at Moffitt Cancer Center have found that a deficiency in an important anti-tumor protein, p53, can slow or delay DNA repair after radiation treatment.  They suggest that this is because p53 regulates the expression of two enzymes (JMJD2b and SUV39H1) that control the folding of DNA. According to the researchers, p53 is highly inducible by radiation. Activation of p53 stabilizes chromosomes by promoting the repair of heterochromatin DNA, which controls the expression of...

2013-04-18 23:31:32

This study will improve genetic counseling and clinical monitoring of patients and families who present these variants Researchers of the hereditary cancer research group at the Bellvitge Biomedical Research Institute (IDIBELL) and the Catalan Institute of Oncology (ICO) conducted a functional and structural study of seven missense variants of the BRCA1 gene concluding that three of these variants are pathogenic, linked to the risk of suffering breast or ovarian cancer. The study has been...

Patent Law For The Human Genome
2013-04-15 06:01:44

redOrbit Staff & Wire Reports - Your Universe Online The US Supreme Court will hear oral arguments on Monday in a case that could determine whether or not human DNA can be patented, which could have a tremendous impact on genetic research, one way or the other. According to Reuters reporter Sharon Begley, “The US Patent and Trademark Office has granted patents on at least 4,000 human genes to companies, universities and others that have discovered and decoded them.”...

2013-04-02 12:32:57

Mutations in a protein called SPOP (speckle-type POZ protein) disarm it, allowing another protein called steroid receptor coactivator-3 (SRC-3) to encourage the proliferation and spread of prostate cancer cells, said researchers led by those at Baylor College of Medicine in a report that appears online in Proceedings of the National Academy of Sciences. Normally SPOP acts as a tumor suppressor gene by marking SRC-3 for destruction, said Dr. Nicholas Mitsiades, assistant professor of...

2013-02-25 13:38:04

Researchers at Karolinska Institutet in Sweden have identified a new so-called pseudogene that regulates the tumor-suppressing PTEN gene. They hope that this pseudogene will be able to control PTEN to reverse the tumor process, make the cancer tumor more sensitive to chemotherapy and to prevent the development of resistance. The findings, which are published in the scientific journal Nature Structural and Molecular Biology, can be of significance in the future development of cancer drugs....

2013-02-12 14:01:58

Information prompts individuals to consult physician, inform relatives A 23andMe study of consumers' reactions to genetic testing found that even when the tests revealed high-risk mutations in individuals, those individuals had few negative reactions to the news. Instead of inducing serious anxiety, the test results prompted people to take positive steps, including follow-up visits with a doctor and discussions with family members who could also be at risk. The study, titled "Dealing...

2013-02-05 10:28:21

Surprising result suggests that enhancing these mutations´ impact could offer a new way to treat cancer. A typical cancer cell has thousands of mutations scattered throughout its genome and hundreds of mutated genes. However, only a handful of those genes, known as drivers, are responsible for cancerous traits such as uncontrolled growth. Cancer biologists have largely ignored the other mutations, believing they had little or no impact on cancer progression. But a new study from...

Breast Cancer Mutation Linked To Early Onset Menopause
2013-01-30 09:42:51

Connie K. Ho for redOrbit.com — Your Universe Online Scientists from the University of California, San Francisco (UCSF) recently conducted a study that showed a significantly earlier onset of menopause for women who inherited a mutation in one of the breast cancer susceptibility (BRCA) genes. These genes, known as BRCA1 or BRCA2, are tumor suppressor genes, meaning that they prevent uncontrolled cell growth. The study is of particular importance as it points to the possibility...

2013-01-14 10:36:16

Metabolic control of p53 points to new cancer therapeutics It is perhaps impossible to overstate the importance of the tumor suppressor gene p53. It is the single most frequently mutated gene in human tumors. p53 keeps pre-cancerous cells in check by causing cells, among other things, to become senescent — aging at the cellular level. Loss of p53 causes cells to ignore the cellular signals that would normally make mutant or damaged cells die or stop growing. In short, the p53...

2012-12-13 12:26:27

Researchers at Michigan State University have discovered a protein that does its best work with one foot in the grave. The study, which appears in the current issue of the Journal of Biological Chemistry, focuses on the nontraditional lifestyle of Retinoblastoma tumor suppressor proteins, which could lead to new ways to treat cancer. “Retinoblastoma proteins are unique in that they use controlled destruction to do their jobs in a timely but restrained fashion,” said Liang...


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malpais
  • The ragged surface of a lava-flow.
'Malpais' translates from Spanish as 'bad land.'