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Latest Tumor suppressor genes Stories

Breast Cancer Mutation Linked To Early Onset Menopause
2013-01-30 09:42:51

Connie K. Ho for redOrbit.com — Your Universe Online Scientists from the University of California, San Francisco (UCSF) recently conducted a study that showed a significantly earlier onset of menopause for women who inherited a mutation in one of the breast cancer susceptibility (BRCA) genes. These genes, known as BRCA1 or BRCA2, are tumor suppressor genes, meaning that they prevent uncontrolled cell growth. The study is of particular importance as it points to the possibility...

2013-01-14 10:36:16

Metabolic control of p53 points to new cancer therapeutics It is perhaps impossible to overstate the importance of the tumor suppressor gene p53. It is the single most frequently mutated gene in human tumors. p53 keeps pre-cancerous cells in check by causing cells, among other things, to become senescent — aging at the cellular level. Loss of p53 causes cells to ignore the cellular signals that would normally make mutant or damaged cells die or stop growing. In short, the p53...

2012-12-13 12:26:27

Researchers at Michigan State University have discovered a protein that does its best work with one foot in the grave. The study, which appears in the current issue of the Journal of Biological Chemistry, focuses on the nontraditional lifestyle of Retinoblastoma tumor suppressor proteins, which could lead to new ways to treat cancer. “Retinoblastoma proteins are unique in that they use controlled destruction to do their jobs in a timely but restrained fashion,” said Liang...

2012-12-11 21:46:12

Mice without the pro-longevity gene SIRT6 had higher risk of gastrointestinal cancers A new study sheds more light on how an anti-aging gene suppresses cancer growth, joint University of Michigan Health System and Harvard Medical School research shows. Loss of the SIRT6 protein in mice increases the number, size and aggressiveness of tumors, according to the new research published in the scientific journal Cell. The study also suggests that the loss of SIRT6 promotes tumor growth in...

2012-12-03 13:47:06

Researchers from the University of Geneva demonstrate that, in this type of lesion, the rate of progression from a precancerous state to the tumor stage accelerates over time The causes underlying the development of certain types of common cancers have not yet been elucidated. In order to better determine the origin and the sequence of events responsible for the onset of colon cancer, the teams led by Thanos Halazonetis and Stylianos Antonarakis, professors at the University of Geneva...

2012-11-29 14:32:03

The combined loss of two tumor suppressor genes, retinoblastoma (RB) and phosphatase and tensin homolog (PTEN) was shown to be strongly associated with progression of DCIS to invasive breast cancer, according to a study published November 28 in the Journal of the National Cancer Institute. Ductal carcinoma in situ (DCIS) is a breast cancer precursor lesion for which there are no established markers defining risk of progression to invasive breast cancer. As a result, the majority of...

2012-11-15 12:37:11

An animal study conducted by researchers at Georgetown Lombardi Comprehensive Cancer Center raises questions about the consequences of diet – specifically glucose, the plant-based sugar that fuels cell life – on increased activity of an oncogene that drives tumor growth. In the study published online today in the journal Cell Cycle, the scientists report, for the first time, that high levels of glucose in the diet of mice with cancer is linked to increased expression of mutant...

Cold Viruses Could Help Find New Cancer Therapies
2012-10-17 11:03:01

[ Watch The Video ] Salk findings on cold virus proteins may spur new cancer treatments Cold viruses generally get a bad rap----which they've certainly earned----but new findings by a team of scientists at the Salk Institute for Biological Studies suggest that these viruses might also be a valuable ally in the fight against cancer. Adenovirus, a type of cold virus, has developed molecular tools----proteins----that allow it to hijack a cell's molecular machinery, including large...

2012-09-20 11:23:52

Decorin, a well-studied protein, induces tumor suppressor genes in microenvironment to stop metastasis, Thomas Jefferson University researchers say A natural substance found in the surrounding tissue of a tumor may be a promising weapon to stop triple negative breast cancer from metastasizing. A preclinical study published in PLOS ONE September 19 by Thomas Jefferson University researchers found that decorin, a well-studied protein known to help halt tumor growth, induces a series of...


Word of the Day
conjunto
  • A style of popular dance music originating along the border between Texas and Mexico, characterized by the use of accordion, drums, and 12-string bass guitar and traditionally based on polka, waltz, and bolero rhythms.
The word 'conjunto' comes through Spanish, from Latin coniūnctus, past participle of coniungere, to join together; see conjoin