Latest Type three secretion system Stories

2010-08-02 06:36:02

Although mechanism had not been recognized before, evidence shows similar mechanism of protein modification occurs in all 5 kingdoms of life Researchers have discovered a novel mechanism in Salmonella that affects its virulence and its susceptibility to antibiotics by changing its production of proteins in a previously unheard of manner. This allows Salmonella to selectively change its levels of certain proteins to respond to inhospitable conditions. Although the mechanism had not been...

2010-06-14 07:17:26

For a successful infection, bacteria must outwit the immune system of the host. To this aim, they deliver so-called virulence factors through a transport channel located in the bacterial membrane. In some bacteria this transport channel is formed like a syringe, enabling them to inject virulence factors directly into the host cell. Scientists from the Max Planck Society and the Federal Institute for Materials Research and Testing have now succeeded for the first time in elucidating basic...

2010-04-16 08:08:59

A new switch that enables Salmonella bacteria to sabotage host cells is revealed in a study published April 15 in the journal Science. The researchers behind the study, from Imperial College London, say that the new finding could ultimately lead to drugs that interfere with the switch in order to combat Salmonella and possibly other bacterial infections. In humans, Salmonella causes diseases ranging from gastroenteritis to typhoid fever. It also causes similar diseases in livestock. Before...

2009-12-28 17:03:39

Just like teenagers at a prom, proteins are tended by chaperones whose job it is to prevent unwanted interactions among immature clients. And at the molecular level, just as at the high school gym level, it's a job that usually requires a lot of energy. In new research, scientists at the University of Michigan and Howard Hughes Medical Institute have discovered how a protein chaperone called HdeA, which helps protect bacteria like the notorious Escherichia coli from the ravages of stomach...

2009-07-07 10:40:50

U.S. and Danish scientists say they've identified proteins that prevent bacteria from infecting a plant's leaves. The researchers at the University of Copenhagen, the University of California-Davis and UC-Berkeley said identifying the proteins will likely find application in better protecting agricultural crops and horticultural plants against diseases. The ability of a plant's immune system to recognize disease-causing microorganisms is critical to the plant's survival and productivity, said...

2009-04-27 12:47:44

U.S. government scientists say they have decoded the structure of a protein complex secretion system that is essential for infection. The research, conducted in part at the U.S. Department of Energy's Brookhaven National Laboratory, involving a needle-like protein complex on the surface of certain bacteria may help scientists develop new strategies to thwart infection. The scientists said their research involved a needle-like protein complex known as a type III secretion system, on the...

2009-04-27 08:35:00

Decoded structure of secretion system, essential for infection, could lead to new drugs New details of the composition and structure of a needlelike protein complex on the surface of certain bacteria may help scientists develop new strategies to thwart infection. The research, conducted in part at the U.S. Department of Energy's Brookhaven National Laboratory, will be published April 26, 2009, in the advance online edition of Nature Structural & Molecular Biology. The scientists were...

2009-03-23 10:08:28

Scientists at the University of Liverpool have demonstrated how a single-celled organism, living freely in the environment, could be a source of Salmonella transmission to animals and humans. Salmonella are microscopic living creatures that can contaminate almost any food type, causing diarrhea, abdominal pain and fever. Scientists know that Salmonella "“ which can also cause typhoid fever "“ has evolved unique mechanisms to prevent the body's immune system from functioning...

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