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Latest Tyrosine kinase receptors Stories

Researchers Discover New Route For Ovarian Cancer Spread
2014-07-15 03:14:42

University of Texas M. D. Anderson Cancer Center HER3-positive circulating tumor cells home in on omentum; new target to thwart metastasis Circulating tumor cells spread ovarian cancer through the bloodstream, homing in on a sheath of abdominal fatty tissue where it can grow and metastasize to other organs, scientists at The University of Texas MD Anderson Cancer Center report in Cancer Cell. "This completely new way of thinking about ovarian cancer metastasis provides new potential...

2014-05-22 10:49:08

CSH Scientists at Cold Spring Harbor Laboratory (CSHL) today report a discovery that they hope will lead to the development of a powerful new way of treating an aggressive form of breast cancer. The breast cancer subtype in question is commonly called “HER2-positive”; it’s a subset of the disease affecting about one patient in four, in which tumor cells overexpress a signaling protein called HER2.  The blockbuster drug Herceptin is a first-line treatment for many women with...

2014-03-26 08:29:12

Proceeds Will Advance Proprietary Biologic Product Candidates Targeting Receptor Tyrosine Kinases NEW HAVEN, Conn., March 26, 2014 /PRNewswire/ -- Kolltan Pharmaceuticals, a privately held biopharmaceutical company focused on the development of novel biologics targeting receptor tyrosine kinases, today announced the completion of a $60 million Series D financing. The financing was led by a new investor, a Boston-based global institutional asset manager, and by an existing investor,...

2013-12-18 09:46:31

The epidermal growth factor receptor (EGFR) is expressed in normal colonic cells and is activated by specific peptide growth factors that regulate cell proliferation, survival and differentiation. Increased expression and activation of the EGFR has been observed in the majority of colorectal carcinoma (CRC), suggesting that the EGFR pathway plays an important role in colon carcinogenesis. The monoclonal antibodies cetuximab and panitumumab are capable of blocking EGFR activity and have...

2013-10-30 15:57:46

Interestingly, a recent study found that ischemic stress causes hyperglycemia and may worsen ischemic neuronal damage. In addition, decreased insulin sensitivity after ischemic stress seems to be involved in the development of post-ischemic glucose intolerance. However, the involvement of brain-derived neurotrophic factor in the development of glucose intolerance following ischemic stress still remains unclear. Xiaoliang Shu and colleagues from the Affiliated Dongfang Hospital of Tongji...

2013-08-07 10:44:28

New findings could lead to drugs that fight back when tumors don't respond to treatment Cancer drugs known as ErbB inhibitors have shown great success in treating many patients with lung, breast, colon and other types of cancer. However, ErbB drug resistance means that many other patients do not respond, and even among those who do, tumors commonly come back. A new study from MIT reveals that much of this resistance develops because a protein called AXL helps cancer cells to circumvent...


Word of the Day
omadhaun
  • A fool; a simpleton: a term of abuse common in Ireland and to a less extent in the Gaelic-speaking parts of Scotland.
This word is partly Irish in origin.