Latest Umut Ozcan Stories
Increased low-grade inflammation in the body resulting from obesity is widely viewed as contributing to type 2 diabetes.
New approach lowers blood sugar in both type 1 and type 2 diabetes BOSTON, Feb. 13, 2011 /PRNewswire-USNewswire/ -- Diabetes can result from either a deficiency of insulin (type 1 or insulin-dependent diabetes) or decreased sensitivity to insulin (type 2 diabetes).
Novel approach may circumvent lost response in insulin due to obesity.
The first known leptin-sensitizing agents induce mice to lose weightThe discovery more than a decade ago of leptin, an appetite-suppressing hormone secreted by fat tissue, generated headlines and great hopes for an effective treatment for obesity. But hopes dimmed when it was found that obese people are unresponsive to leptin due to development of leptin resistance in the brain. Now, researchers at Children's Hospital Boston report the first agents demonstrated to sensitize the brain to...
A new study in the January 7th issue of Cell Metabolism, a Cell Press publication, helps to explain why obese people and animals fail to respond to leptin, a hormone produced by fat that signals the brain to stop eating. What's more, they show that two FDA-approved drugs might restore leptin sensitivity, offering a novel treatment for obesity." Most importantly, our study is the first success in sensitizing obese mice on a high-fat diet to leptin," said Umut Ozcan of Harvard Medical School....
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