Quantcast

Latest Umut Ozcan Stories

2011-09-05 11:40:18

Study finds inflammation may be part of the solution, not the problem Increased low-grade inflammation in the body resulting from obesity is widely viewed as contributing to type 2 diabetes. Going against this long-held belief, researchers from Children's Hospital Boston report that two proteins activated by inflammation are actually crucial for maintaining good blood sugar levels — and that boosting the activity of these proteins can normalize blood sugar in severely obese and...

2011-02-13 12:00:00

New approach lowers blood sugar in both type 1 and type 2 diabetes BOSTON, Feb. 13, 2011 /PRNewswire-USNewswire/ -- Diabetes can result from either a deficiency of insulin (type 1 or insulin-dependent diabetes) or decreased sensitivity to insulin (type 2 diabetes). Researchers at Children's Hospital Boston have discovered a mechanism for normalizing blood sugar that doesn't involve insulin and could offer a new therapeutic approach to both kinds of diabetes. Reporting in Nature Medicine...

2010-03-29 07:36:53

Novel approach may circumvent lost response in insulin due to obesity Researchers at Children's Hospital Boston have identified a new strategy for treating type 2 diabetes, identifying a cellular pathway that fails when people become obese. By activating this pathway artificially, they were able to normalize blood glucose levels in severely obese and diabetic mice. Their findings were published online by Nature Medicine on March 28. Epidemiologists have long known that obesity contributes to...

2009-01-07 09:19:09

The first known leptin-sensitizing agents induce mice to lose weightThe discovery more than a decade ago of leptin, an appetite-suppressing hormone secreted by fat tissue, generated headlines and great hopes for an effective treatment for obesity. But hopes dimmed when it was found that obese people are unresponsive to leptin due to development of leptin resistance in the brain. Now, researchers at Children's Hospital Boston report the first agents demonstrated to sensitize the brain to...

2009-01-07 09:02:21

A new study in the January 7th issue of Cell Metabolism, a Cell Press publication, helps to explain why obese people and animals fail to respond to leptin, a hormone produced by fat that signals the brain to stop eating. What's more, they show that two FDA-approved drugs might restore leptin sensitivity, offering a novel treatment for obesity." Most importantly, our study is the first success in sensitizing obese mice on a high-fat diet to leptin," said Umut Ozcan of Harvard Medical School....


Word of the Day
ramage
  • Boughs or branches.
  • Warbling of birds in trees.
Related