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Latest Unfolded protein response Stories

2014-07-02 10:16:43

APS A diagnosis of pancreatic cancer—the fourth most common cause of cancer death in the U.S.—can be devastating. Due in part to aggressive cell replication and tumor growth, pancreatic cancer progresses quickly and has a low five-year survival rate (less than 5 percent). GRP78, a protein that protects cells from dying, is more abundant in cancer cells and tissue than in normal organs and is thought to play a role in helping pancreatic cancer cells survive and thrive. Researchers at...

2013-06-17 12:13:57

UCSF cell biologists find molecule targets a key biological pathway Memory improved in mice injected with a small, drug-like molecule discovered by UCSF San Francisco researchers studying how cells respond to biological stress. The same biochemical pathway the molecule acts on might one day be targeted in humans to improve memory, according to the senior author of the study, Peter Walter, PhD, UCSF professor of biochemistry and biophysics and a Howard Hughes Investigator. The...

2012-12-19 11:28:22

Researchers at the University of California, San Diego School of Medicine report that tumor cells use stress signals to subvert responding immune cells, exploiting them to actually boost conditions beneficial to cancer growth. The findings are published in the December 18 online issue of the journal PLOS ONE. Lead author Navin R. Mahadevan, a graduate student in the Laboratory of Immunology at the UC San Diego Moores Cancer Center, and colleagues found that tumor cells manipulate a...

Crops Possibly Protected From Stressors Due To New Discovery
2012-08-31 16:37:30

Salk findings of a key genetic mechanism in plant hormone signaling may help save crops from stress and help address human hunger Scientists at the Salk Institute for Biological Studies have discovered a key genetic switch by which plants control their response to ethylene gas, a natural plant hormone best known for its ability to ripen fruit, but which, under stress conditions, can cause wilted leaves, premature aging and spoilage from over-ripening. The findings, published August 30 in...

2012-08-07 23:33:26

Inflammation and cell stress play important roles in the death of insulin-secreting cells and are major factors in diabetes. Cell stress also plays a role in Wolfram syndrome, a rare, genetic disorder that afflicts children with many symptoms, including juvenile-onset diabetes. Now a molecule has been identified that's key to the cell stress-modulated inflammation that causes insulin cells to die, report scientists at Washington University School of Medicine in St. Louis, the University of...

2012-07-02 21:42:17

Researchers at Georgetown Lombardi Comprehensive Cancer Center have uncovered a single molecule they say is a major determinant of resistance to anti-estrogen therapy used to treat or prevent breast cancer in high-risk women. In the July 1 issue of Cancer Research, the scientists say glucose-regulated protein 78 (GRP78), activated as breast cells undergo stress induced by the agents tamoxifen and fulvestrant, turns off apoptosis, a cell death response, and turns on autophagy. In autophagy,...

2012-07-02 06:07:17

(Ivanhoe Newswire) — Researchers have discovered a single molecule that they say is a major cause of resistance to anti-estrogen therapy used to prevent or treat breast cancer in high-risk women. The researchers say glucose-regulated protein 78 (GRP78), which is triggered as breast cells become stressed from the agents tamoxifen and fulvestrant, turns off apoptosis (a cell death response) and turns on autophagy. Autophagy occurs when the cell "eats" and digests components within the...

2012-06-29 10:40:39

'Paper of the week' shows that a master regulator protein brings plethora of coactivators to gene expression sites Molecular geneticists call big boss proteins that switch on broad developmental or metabolic programs "master regulators," as in master regulators of muscle development or fat metabolism. One such factor, the Activating Transcription Factor 6α (ATF6α) protein, takes charge following a cellular crisis known as endoplasmic reticulum (ER) stress,...


Word of the Day
mallemaroking
  • Nautical, the visiting and carousing of sailors in the Greenland ships.
This word is apparently from a confusion of two similar Dutch words: 'mallemerok,' a foolish woman, and 'mallemok,' a name for some persons among the crew of a whaling vessel.