Quantcast

Latest University of Pennsylvania School Stories

7b0ebda6805266668ff54c482ff0ed451
2009-10-30 10:00:29

Like yoga for office drones, cells do have coping strategies for stress. Heat, lack of nutrients, oxygen radicals "“ all can wreak havoc on the delicate internal components of a cell, potentially damaging it beyond repair. Proteins called HSPs (heat shock proteins) allow cells to survive stress-induced damage. Scientists have long studied how HSPs work in order to harness their therapeutic potential. Donna George, PhD, Associate Professor of Genetics, and Julie Leu, PhD, Assistant...

2009-10-24 13:00:00

PHILADELPHIA, Oct. 24 /PRNewswire/ -- Born with a retinal disease that made him legally blind, and would eventually leave him totally sightless, the nine-year-old boy used to sit in the back of the classroom, relying on the large print on an electronic screen and assisted by teacher aides. Now, after a single injection of genes that produce light-sensitive pigments in the back of his eye, he sits in front with classmates and participates in class without extra help. In the playground, he...

d17fc7869f516d12d393f4ff21295a301
2009-10-16 09:39:00

Research Supports Potential for New Anti-Cancer Agent A study published in the October issue of Nature Genetics demonstrates that loss of the tumor-suppressor protein p53, coupled with elimination of the DNA-maintenance protein ATR, severely disrupts tissue maintenance in mice. As a result, tissues deteriorate rapidly, which is generally fatal in these animals. In addition, the study provides supportive evidence for the use of inhibitors of ATR in cancer therapy. Essentially, says senior...

2009-09-30 05:00:00

Those possessing gun in assault situation 4.5 times more likely to be shot than those not possessing one PHILADELPHIA, Sept. 30 /PRNewswire-USNewswire/ -- In a first-of-its-kind study, epidemiologists at the University of Pennsylvania School of Medicine found that, on average, guns did not protect those who possessed them from being shot in an assault. The study estimated that people with a gun were 4.5 times more likely to be shot in an assault than those not possessing a gun....

acb00afa485e9a708e0ee2657f71c6531
2009-09-13 07:51:40

Best known as the oxygen-carrying component of hemoglobin, the protein that makes blood red, heme also plays a role in chemical detoxification and energy metabolism within the cell. Heme levels are tightly maintained, and with good reason: Too little heme prevents cell growth and division; excessive amounts of heme are toxic. Researchers at the University of Pennsylvania School of Medicine have discovered a molecular circuit involving heme that helps maintain proper metabolism in the body,...

2009-08-19 09:28:48

The nation's home foreclosure epidemic may be taking its toll on Americans' health as well as their wallets. Nearly half of people studied while undergoing foreclosure reported depressive symptoms, and 37 percent met screening criteria for major depression, according to new University of Pennsylvania School of Medicine research published online this week in the American Journal of Public Health. Many also reported an inability to afford prescription drugs, and skipping meals. The authors say...

d42062ea4ed48874a76c016665932faa1
2009-08-17 16:25:00

"A biologist, a physicist, and a nanotechnologist walk into a ..." sounds like the start of a joke. Instead, it was the start of a collaboration that has helped to decipher a critical, but so far largely unstudied, phase of how cells divide. Errors in cell division can cause mutations that lead to cancer, and this study could shed light on the role of chromosome abnormalities in uncontrolled cell replication.The biologist in question is University of Pennsylvania School of Medicine Associate...

4bc36196066b06c06a24f9c2d8dcf97f1
2009-08-13 13:45:00

Breast cancer survivors can reduce the impact of post-surgery swelling by lifting weights, according to new research. Writing in the New England Journal of Medicine on Thursday, researchers from the University of Pennsylvania School of Medicine found that breast cancer survivors who lift weights and exercise their upper body can reduce the swelling symptoms of lymphedema. Lymphedema is a condition that results from treatment of breast cancer when lymph nodes are removed from under the arms....

2009-08-13 11:06:34

 One year after a trio of young adults received gene therapy for an inherited form of blindness, researchers have documented that the patients are still experiencing the same level of remarkable vision improvements previously measured within weeks. This is the first study to report one-year gene therapy safety and efficacy results in treating young adults with Leber Congenital Amaurosis (LCA), a hereditary condition that causes severe vision impairment in infants and children. The...

d91cac536c606e2d2d8d4db0b9ee1e58
2009-08-06 14:45:00

Fibrin, the chief ingredient of blood clots, is a remarkably versatile polymer. On one hand, it forms a network of fibers -- a blood clot -- that stems the loss of blood at an injury site while remaining pliable and flexible. On the other hand, fibrin provides a scaffold for thrombi, clots that block blood vessels and cause tissue damage, leading to myocardial infarction, ischemic stroke, and other cardiovascular diseases. How does fibrin manage to be so strong and yet so extensible under the...


Word of the Day
humgruffin
  • A terrible or repulsive person.
Regarding the etymology of 'humgruffin,' the OED says (rather unhelpfully) that it's a 'made-up word.' We might guess that 'hum' comes from 'humbug' or possibly 'hum' meaning 'a disagreeable smell,' while 'gruffin' could be a combination of 'gruff' and 'griffin.'