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Latest Unsolved problems in neuroscience Stories

2012-01-12 12:11:39

Exposure to light appears to have therapeutic effects on Alzheimer's disease patients, a Wayne State University researcher has found. In a study published recently in the Western Journal of Nursing Research, LuAnn Nowak Etcher, Ph.D., assistant professor of nursing, reported that patients treated with blue-green light were perceived by their caregivers as having improved global functioning. Caregivers said patients receiving the treatment seemed more awake and alert, were more verbally...

2012-01-04 07:45:00

Analysis of Available Biomarkers Will Guide FDA and Industry in Design of Clinical Trials to Speed Search for Disease-Modifying Treatments WASHINGTON, Jan. 4, 2012 /PRNewswire-USNewswire/ -- A group of thought leaders in Alzheimer's disease says the science is solid and the time has come for more widespread use of biomarkers in Alzheimer disease (AD) clinical trials, to speed the identification of effective disease-modifying treatments for this incurable disorder. Recommendations by the...

2012-01-03 12:19:39

The first changes in the brain of a person with Alzheimer´s disease can be observed as much as ten years in advance — ten years before the person in question has become so ill that he or she can be diagnosed with the disease. This is what a new study from Lund University in Sweden has found. Physician Oskar Hansson and his research group are studying biomarkers — substances present in spinal fluid and linked to Alzheimer´s disease. The group has studied close to 140...

2012-01-02 23:14:46

Cerebrospinal fluid levels of Aβ42 appear to be decreased at least five to 10 years before some patients with mild cognitive impairment develop Alzheimer disease (AD) dementia whereas other spinal fluid levels seem to be later markers of disease, according to a report in the January issue of Archives of General Psychiatry, one of the JAMA/Archives journals. The researchers note as background in the study that disease-modifying therapies, such as immunotherapy, are more likely to be...

2011-12-23 06:48:49

(Ivanhoe Newswire) — Treatment that increases brain levels of a crucial regulatory enzyme may slow the loss of brain cells that characterize Huntington´s disease (HD) and other neurodegenerative disorders, according to this study. Increased expression of Sirt1, one of a family of enzymes called sirtuins, in the brain of a mouse model of HD protected against neurodegeneration. They also identified a potential mechanism for this protective effect. "Diseases such as Huntington's,...

2011-12-19 08:00:00

CAMBRIDGE, Mass., Dec. 19, 2011 /PRNewswire-USNewswire/ -- The ALS Therapy Development Institute (ALS TDI) today announced a research agreement with Biogen Idec (NASDAQ: BIIB) and UCB Pharma SA (EN Brussels: UCB) to investigate the use of an anti-CD40L antibody as a potential therapy for Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig's or Motor Neuron Disease. Financial terms of the agreement were not disclosed. (Logo: http://photos.prnewswire.com/prnh/20110204/DC42625LOGO)...

2011-12-16 05:00:00

Employees at Emeritus Senior Livingâs 485 communities showed their commitment to seniors by holding hundreds of fundraisers across the nation to support the 2011 Alzheimerâs Associationâs Walk to End Alzheimerâs. Funds raised total $404,602 â“ exceeding last yearâs total by more than $130,000 â“ to help build Alzheimer's awareness and fund care, support and research. Seattle, Washington...

Alzheimer's Drug Candidate Could Prevent Disease Progression
2011-12-15 04:55:47

[ Watch the Video ] Salk scientists develop new drug that improves memory and prevents brain damage in mice A new drug candidate may be the first capable of halting the devastating mental decline of Alzheimer's disease, based on the findings of a study published Dec. 14 in PLoS ONE. When given to mice with Alzheimer's, the drug, known as J147, improved memory and prevented brain damage caused by the disease. The new compound, developed by scientists at the Salk Institute for...

2011-12-14 12:06:01

When you cut an apple and leave it out, it turns brown. Squeeze the apple with lemon juice, an antioxidant, and the process slows down. Simply put, that same "browning" process-known as oxidative stress-happens in the brain as Alzheimer's disease sets in. The underlying cause is believed to be improper processing of a protein associated with the creation of free radicals that cause oxidative stress. Now, a study by researchers in the University of Georgia College of Pharmacy has shown...

2011-12-14 12:01:23

New potential avenues for early disease detection A study led by Research Professor Matej Orešič from VTT Technical Research Centre of Finland suggests that Alzheimer's disease is preceded by a molecular signature indicative of hypoxia and up-regulated pentose phosphate pathway. This indicator can be analyzed as a simple biochemical assay from a serum sample months or even years before the first symptoms of the disease occur. In a healthcare setting, the application...