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Latest Unsolved problems in neuroscience Stories

2011-11-23 11:31:47

How does awareness influence information processing during decision making in the human brain? A new study led by Floris de Lange of the Donders Institute for Brain, Cognition and Behavior at Radboud University Nijmegen, offers new insight into this question, and is published November 22 in the online, open-access journal PLoS Biology. When making a decision, we gather evidence for the different options and ultimately choose on the basis of the accumulated evidence. A fundamental question...

2011-11-21 09:24:08

Treatment with dexpramipexole — a novel drug believed to prevent dysfunction of mitochondria, the subcellular structures that provide most of a cell's energy — appears to slow symptom progression in the neurodegenerative disease amyotrophic lateral sclerosis (ALS). Promising results of a phase 2 trial of dexpramipexole are receiving advance online publication in Nature Medicine. Some preliminary results of the study were presented at the 2009 International Symposium on ALS/MND and...

2011-11-18 02:00:00

SPRINGFIELD, Mass., Nov. 18, 2011 /PRNewswire/ -- Mitchell Clionsky, Ph.D. and Emily Clionsky, M.D. of CNS-Neuro, announced new data supporting the use of screening tests to identify cognitive loss in older Americans. Their study asked two hundred elderly patients and their families to rate how well they think and remember. They found that the patients' answers had no relationship to their tested cognitive ability, that the relatives were minimally better, and that doctors should...

2011-11-16 16:40:00

NEW YORK, Nov. 16, 2011 /PRNewswire/ -- Oligomerix, Inc. presented results at the Society for Neuroscience meeting in Washington D.C. which demonstrated that tau protein forms neurotoxic oligomers with a newly discovered enzymatic function. This proteolytic function results in tau's self-fragmentation and in the degradation of other proteins suggesting a mechanism for its neurotoxic mode-of-action. Furthermore, certain tau oligomer species that contained the highest level of activity also...

2011-11-14 23:24:26

Georgetown researchers say therapy may work best in patients with early disease when amyloid burden is lower Patients with Alzheimer's disease who are in the early stages of their illness will likely benefit most from vaccine therapies now being tested in a number of human clinical trials, say researchers from Georgetown University Medical Center (GUMC). Their study, presented at the annual meeting of the Society for Neuroscience, Neuroscience 2011, is the first to show that mice with a...

2011-11-14 23:12:47

Two proteins conspire to promote a lethal neurological disease, according to a study published online this week in the Journal of Experimental Medicine (www.jem.org). Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a devastating neurodegenerative disorder that results in progressive loss of motor function and ultimately death. More than 90% of ALS cases have no known genetic cause or family history. However, in some patients, spinal cord cells contain unusual...

2011-11-14 08:00:00

ANN ARBOR, Mich., Nov. 14, 2011 /PRNewswire/ -- Adeona Pharmaceuticals, Inc. (AMEX: AEN), a developer of innovative medicines for serious central nervous system diseases, today reported its third quarter 2011 financial results for the period ended September 30, 2011, as well as updates since the beginning of the third quarter. Updates since the beginning of the third quarter include: Drug Development Programs Relapsing-Remitting Multiple Sclerosis (MS) As of September 19, 2011, the...

2011-11-11 01:38:50

Brain imaging experiments uncouple two apparently intimately connected mental processes In everyday life, attention and awareness appear tightly interwoven. Attending to the scissors on the right side of your desk, you become aware of their attributes, for example the red handles. Vice versa, the red handles could attract your attention to the scissors. However, a number of behavioural observations have recently led scientists to postulate that attention and awareness are fundamentally...

2011-11-07 19:59:07

Hirano bodies are almost indescribably tiny objects found in nerve cells of people suffering from conditions such as Alzheimer's, mad cow and Lou Gehrig's diseases. Yet for decades, researchers weren't sure if these structures helped cause the conditions or appeared after onset of the disease and had some other role. Now, in research at the University of Georgia, a cellular biologist and his colleagues have found that Hirano bodies may play a protective role in the progression of...

2011-11-02 09:06:07

Neurofibrillary tangles — odd, twisted clumps of protein found within nerve cells — are a pathological hallmark of Alzheimer's disease. The tangles, which were first identified in the early 1900s by German psychiatrist and neuropathologist Aloysius Alzheimer, are formed when changes in a protein called tau cause it to aggregate in an insoluble mass in the cytoplasm of cells. Normally, the tau protein is involved in the formation of microtubules, hollow filaments that provide cells...